Publications by authors named "Disha"

Objectives: The paper aims to assess the level of antibiotic use and the antibiotic types used generally in dentistry and identify self-reported allergies and resistance related to them.

Methods: The data were collected between March and May 2024 via an electronic questionnaire on self-reported antibiotic usage, antibiotic allergies and resistances among individual in Albania.

Results: A total of 477 individuals (83% females, 17% males) with a mean 33 ± 13 (min 17; max 73) years of age completed the questionnaire.

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  • - Anxiety is a normal reaction to stress that leads to feelings of worry and fear, and this study examined how indirubin (IND) affects anxiety in mice using various behavioral tests.
  • - The research found that administering different doses of IND significantly reduced anxious behaviors in the mice, similar to the effects of diazepam, a common anti-anxiety medication.
  • - Molecular analysis showed that IND binds effectively to GABA receptors, particularly the α3 subunit, indicating its potential as a therapeutic agent for anxiety with favorable drug-like properties.
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  • Tori are bony growths in the mouth linked to genetic and environmental factors, which can affect oral hygiene and function.
  • A study conducted at Diamond Dental Hospital in Tirana, Albania found a high prevalence of oral tori at 48%, particularly in the 18-29 age group.
  • The most common type identified was torus mandibularis (39%), and this research highlights the significance of recognizing oral tori in dental practice, as their prevalence isn't influenced by gender or bruxism.
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Carbonic anhydrase 5A (CA5A) belongs to a family of carbonic anhydrases which are zinc metalloenzymes involved in the reversible hydration of CO to bicarbonate. Mutations in CA5A are very rare and known to cause Carbonic anhydrase 5A deficiency (CA5AD), an autosomal recessive inborn error of metabolism characterized clinically by acute onset of encephalopathy in infancy or early childhood. CA5A also has two very identical pseudogenes whose interference may result in compromised accuracy in targeted sequencing.

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Chronic obstructive pulmonary disease (COPD) is a preventable and treatable disease of airflow limitation that is not fully reversible. COPD affects the lungs and produces significant systemic consequences. In Bangladesh, the prevalence of COPD after 40 years of age is 21.

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  • Aeromonas hydrophila is a harmful pathogen in aquaculture, causing economic losses, but recent advancements in nanotechnology could help create effective vaccines.
  • This study examined a vaccine using nanoparticle-loaded outer membrane protein A (OmpA) from A. hydrophila, showing good size and encapsulation efficiency with promising results in zebrafish models.
  • The oral administration of the nanoparticle vaccine led to a 77.7% survival rate in infected zebrafish, suggesting it stimulates a strong immune response and offers significant protection against the pathogen.
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Unlabelled: This prospective clinical study aimed to assess self-reported orofacial esthetics, chewing function, and oral health-related quality of life (OHRQoL) over three years in the Kennedy Class I patients without posterior dentition who received free-end saddle removable partial dentures (RPDs) retained by two mini dental implants (MDIs) inserted in the canine/first premolar region. The study's robust findings reaffirm the viability of MDI-retained RPDs as a treatment modality in contemporary prosthodontics, instilling confidence in the dental community.

Materials And Methods: 92 participants with posterior edentulism in the maxilla or mandible received 184 MDIs and 92 RPDs.

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  • Nature exposure has been recognized as a helpful coping mechanism for mental health during the COVID-19 pandemic, but prior reviews didn't assess the evidence quality or bias of empirical studies.
  • A systematic review and meta-analysis, using the Navigation Guide methodology, evaluated 113 studies on how different types of nature exposure correlate with various mental health outcomes, such as depression, anxiety, and stress.
  • Results indicated that access to gardens and increased time spent in green spaces were associated with lower depression and anxiety levels and improved general mental well-being, but overall evidence quality was rated very low due to high bias in many studies.
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Unlabelled: Enamel hypoplasia (EH) is a qualitative defect, and it can have a significant impact on oral health. The aim of this study was to evaluate the prevalence of enamel hypoplasia in urban area in Albania.

Methodology: In total, 234 children of both sexes aged 8-12 years old were randomly selected in five schools in Tirana, Albania.

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A community-level nutritional intervention was implemented among tribal children (3 to 6 years of age) in Telangana, India. The one-year intervention involved six nutrient-rich formulations of millet-pulse-groundnut-based products suited to local taste preferences. Anthropometric measurements of height, weight, and mid-upper-arm circumference (MUAC) along with haemoglobin (Hb) levels were monitored at baseline and endline.

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Pancreatic tuberculosis (TB) warrants heightened suspicion in individuals with pancreatic lesions and risk factors such as HIV, organ transplantation, or pertinent immigration history. We present a 38-year-old man who presented with hemodynamically unstable gastrointestinal bleeding. He was found to have pancreatic TB complicated by a duodenal ulcer with fistula.

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  • * Researchers are exploring the oral delivery of a vaccine using nano-biotechnology, specifically focusing on the outer membrane protein maltoporin as a potential candidate.
  • * The study demonstrates successful encapsulation of maltoporin in a biodegradable polymer, resulting in a promising delivery system that could effectively trigger immune responses in fish through oral administration.
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Introduction: The COVID-19 pandemic has had a significant impact on mental health globally, with limited access to mental health care affecting low- and middle-income countries (LMICs) the most. In response, alternative strategies to support mental health have been necessary, with access to green spaces being a potential solution. While studies have highlighted the role of green spaces in promoting mental health during pandemic lockdowns, few studies have focused on the role of green spaces in mental health recovery after lockdowns.

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Mitochondria are an indispensable part of the cell that plays a crucial role in regulating various signaling pathways, energy metabolism, cell differentiation, proliferation, and cell death. Since mitochondria have their own genetic material, they differ from their nuclear counterparts, and dysregulation is responsible for a broad spectrum of diseases. Mitochondrial dysfunction is associated with several disorders, including neuro-muscular disorders, cancer, and premature aging, among others.

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Salinity variations are the main reason for rice yield fluctuations in salt-prone regions throughout the dry season (Boro season). Plant breeders must produce new rice varieties that are more productive, salt tolerant, and stable across a variety of settings to ensure Bangladesh's food sustainability. To assess the yield and stability, we used fifteen rice genotypes containing two tolerant checks BRRI dhan67, Binadhan-10 and the popular Boro rice variety BRRI dhan28 in different salinity "hotspot" in three successive years followed by additive main effects and multiplicative interaction (AMMI) model utilizing a randomized complete block (RCB) design with two replications.

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In this study, we have introduced a method for the synthesis of various metal-doped nano-crystalline hydroxyapatites (HAp) using a standard wet chemical precipitation technique. Both divalent (Ni and Zn) and trivalent (Al and Fe) metals were selected for the doping process. Additional research work was also conducted to assess the antimicrobial efficacy of these doped-HAps against a range of gram-positive and gram-negative microorganisms.

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Introduction: The vaccination against coronavirus disease 2019 (COVID-19) has been identified as a promising strategy to reduce the severity of the pandemic. Despite the safe and effective COVID-19 vaccines, bringing socioeconomically disadvantaged people under vaccination coverage has been challenging for developing countries like Bangladesh. Therefore, this study explored the determinants of vaccine acceptance among urban slum residents of Bangladesh using the Health Belief Model (HBM) and Theory of Planned Behavior (TPB).

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  • Eco-friendly alternatives like probiotics are essential in aquaculture to combat infectious diseases and reduce reliance on antibiotics, which can cause resistance and residues in fish.
  • The isolated probiotic, TLDK301120C24, identified as Bacillus subtilis, demonstrated effectiveness against key bacterial pathogens in tests and could thrive in various gut conditions.
  • Further research confirmed the probiotic’s ability to inhibit pathogens like Aeromonas hydrophila and Edwardsiella tarda in live zebrafish, highlighting its potential as a natural disease control method in fish farming.
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Background This cross-sectional study aims to evaluate pain management's success in limiting admissions and assesses remote care's effectiveness for optimal pain relief. By utilizing data from severe COVID-19 inpatients in Prishtina, Kosovo, this study offers insights into the challenges posed by the pandemic and innovative care approaches aimed at improving patient well-being. Methodology This cross-sectional study includes 55 patients with severe COVID-19 after hospital discharge.

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The application of nanotechnology in aquaculture for developing efficient vaccines has shown great potential in recent years. Nanovaccination, which involves encapsulating antigens of fish pathogens in various polymeric materials and nanoparticles, can afford protection to the antigens and a sustained release of the molecule. Oral administration of nanoparticles would be a convenient and cost-effective method for delivering vaccines in aquaculture while eliminating the need for stressful, labour-intensive injectables.

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Dengue is an emerging, mosquito-borne viral disease of international public health concern. Dengue is endemic in more than 100 countries across the world. However, there are no clinically approved antivirals for its cure.

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