Baseline and Corticotropin-Stimulated Blood Steroid Profiles in Women of Reproductive Age in India: A Cross-Sectional Study and Global Literature Review.

Introduction: Corticotropin (adrenocorticotropic hormone (ACTH))-stimulated blood steroid profile is useful in the diagnosis of rare adrenal disorders but their utility is limited due to lack of assay- and population-specific reference ranges. Hence, we conducted this study to establish the reference ranges for basal and ACTH-stimulated blood steroid profiles in Indian women of reproductive age.

Methods: This cross-sectional study included 30 apparently healthy female volunteers aged 18-40 years.

Subcutaneous route is a reliable alternative for ACTH-stimulated steroid profiling.

Purpose: Intramuscular acton prolongatum is most often used as an alternative for intramuscular or intravenous tetracosactide for ACTH stimulation in some countries. Intramuscular administration of acton prolongatum is cumbersome whereas intended intramuscular acton prolongatum or tetracosactide may often turn subcutaneous. Hence, we compared the subcutaneous ACTH-stimulated steroid profiling with those of the intramuscular routes.

Validating phosphoethanolamine modification as a potential spectral marker of colistin resistance.

The antibiotic colistin is regarded as the final line of defense for treating infections caused by Gram-negative bacteria. The combination of Raman spectroscopy (RS) with diverse machine learning methods has helped unravel the complexity of various microbiology problems. This approach offers a culture-free, rapid, and objective tool for identifying antimicrobial resistance (AMR).

High-Performance Battery-Type Supercapacitors Based on Self-Oriented Growth of Nanorods/Nanospheres Composite Assembled on Self-Standing Conductive GO/CNF Frameworks.

MnO-based materials have limited capacity and poor conductivity over various voltages, hampering their potential for energy storage applications. This work proposes a novel approach to address these challenges. A self-oriented multiple-electronic structure of a 1D-MnO-nanorod/2D-MnO-nanosphere composite was assembled on 2D-graphene oxide nanosheet/1D-carbon nanofiber (GO/CNF) hybrids.

Tuberculosis treatment spills the beans on Wilson's disease and more.

Drug-induced liver injury (DILI) is an unwarranted problem and has been a scourge in the treatment of tuberculosis (TB) infection in general and children in particular. Usually, when the Antituberculosis treatment (ATT) regime is temporarily interrupted and modified, DILI subsides, and the whole treatment can be completed under supervision. We report a case of ATT-induced DILI not improving despite modification in the ATT regime, which ultimately led to the revealing of a yet unreported constellation of syndromes that included Wilson Disease, 46 XX gonadal dysgenesis, and Mayer Rokitansky Kuster Hauser (MRKH) Syndrome.

Novel Psilocin Prodrugs with Altered Pharmacological Properties as Candidate Therapies for Treatment-Resistant Anxiety Disorders.

The psychedelic prodrug psilocybin has shown therapeutic benefits for the treatment of numerous psychiatric conditions. Despite positive clinical end points targeting depression and anxiety, concerns regarding the duration of the psychedelic experience produced by psilocybin, associated with enduring systemic exposure to the active metabolite psilocin, pose a barrier to its therapeutic application. Our objective was to create a novel prodrug of psilocin with similar therapeutic benefits but a reduced duration of psychedelic effects compared with psilocybin.

Comparison of noninvasive cardiac output monitoring by electrical cardiometry with transthoracic echocardiography in postoperative paediatric cardiac surgical patients - A prospective observational study.

Aim: The present study was conducted to validate cardiac output (CO) and cardiac index (CI) obtained from electrical cardiometry (EC) ICON with transthoracic echocardiography (TTE) in postoperative pediatric cardiac surgical patients.

Materials And Methods: A prospective observational study was conducted in 25 pediatric patients with age < 10 years who underwent elective cardiac surgery.

Data Analysis: BlandAltman plot was constructed for interchangeability and Polar plot was constructed to know trending ability.

Idiopathic Intracranial Hypertension following Levothyroxine Replacement Therapy: Systematic Review and a Case Report.

The data on the characteristics of patients with idiopathic intracranial hypertension (IIH) following levothyroxine (LT4) replacement are limited. Here, we report a case and systematically review published cases of idiopathic intracranial hypertension (IIH) following levothyroxine (LT4) replacement. The systematic review was performed as per the PRISMA guidelines.

Enhanced Electrochemical Performance of Rare-Earth Metal-Ion-Doped Nanocrystalline LiTiO Electrodes in High-Power Li-Ion Batteries.

A comprehensive and comparative exploration research performed, aiming to elucidate the fundamental mechanisms of rare-earth (RE) metal-ion doping into LiTiO (LTO), reveals the enhanced electrochemical performance of the nanocrystalline RE-LTO electrodes in high-power Li-ion batteries. Pristi ne LiTiO (LTO) and rare-earth metal-doped LiTiLnO (RE-LTO with RE = Dy, Ce, Nd, Sm, and Eu; ≈ 0.1) nanocrystalline anode materials were synthesized using a simple mechanochemical method and subsequent calcination at 850 °C.

The effect of levosimendan on the right ventricular function in patients with right ventricular dysfunction undergoing mitral valve surgery.

Background: Right ventricular (RV) dysfunction is an important predictor of both immediate and long-term outcomes in valve surgeries. Levosimendan has proven beneficial in improving RV function.

Aims: The objective was to study the effect of the addition of levosimendan to the conventional treatment on RV function in patients with RV dysfunction undergoing mitral valve (MV) surgeries.

A Comparative Study on Accuracy of SRK-T And Haigis Formulas in IOL Power Calculation in Axial Myopes Undergoing Cataract Surgery.

Background And Objective: It has been a significant challenge since the advent of intraocular lens to give the best postoperative visual acuity and prevent refractive surprises due to biometry error. Among myopic eyes, it has been a debate among the various formulas introduced and their efficacy to prevent postoperative refractive surprises. Hence, the need for an accurate formula in high myopic eyes is obligatory.

Auto-immune thyroiditis in SARS-CoV-2 exposed twins.

Objective: In the coronavirus disease 2019 (COVID-19) pandemic, a spectrum of sequelae affecting different organs has been reported. Of these, the ones affecting the thyroid gland have been reported, especially in the adults.

Case Report: We present previously healthy twin adolescents with no history of thyroid disease, presenting with signs and symptoms of hypothyroidism after recovery from mild COVID-19 infection.

Long-acting Porcine Sequence ACTH (Acton Prolongatum) Stimulation Test is a Reliable Alternative Test as Compared to the Gold Standard Insulin Tolerance Test for the Diagnosis of Adrenal Insufficiency.

Context: As synacthen use is not licensed in India and there are concerns about the safety of the insulin tolerance test (ITT), an alternative dynamic test to diagnose adrenal insufficiency (AI) is required.

Objective: The study aimed to evaluate the diagnostic performance of the Acton Prolongatum stimulation test (APST) with a standard ITT for the diagnosis of AI.

Design: Prospective study comparing two diagnostic tests.

Role of Lipid Indices in the Assessment of Microvascular Risk in Type 2 Diabetic Retinopathy Patients.

Introduction: Diabetic retinopathy (DR) remains the leading cause of blindness and visual impairment in diabetic patients worldwide. Lipid indices (LI) such as atherogenic coefficient (AC), atherogenic index of plasma (AIP), non-high-density lipoprotein cholesterol (non-HDL-C), and Castelli risk index (CRI) I and II may be associated with bio-physiological changes of DR even when traditional lipids are within normal limit. Hence, the present study was undertaken to evaluate the LI and examine the LI predictive role in assessing the microvascular risk in diabetes patients with and without retinopathy.

A Scanning Electron Microscope Evaluation of the Efficacy of Different Fluoride-releasing Dental Restorative Materials to Prevent Enamel Demineralization: An Study.

Aim: Aim of the present research was to investigate the effectiveness of various fluoride-releasing dental restorative agents in preventing demineralization of enamel.

Materials And Methods: Eighty human mandibular permanent molar teeth constituted the study group. All samples were subjected to storage in thymol, after which they were taken out to prepare alike proximal box in each.

A Needle in the Fetal Brain: The Rare Role of Transabdominal Cephalocentesis in Fetal Hydrocephalus.

Fetal hydrocephalus is a fairly common occurrence in pregnant women, surfacing early or late in the pregnancy. The perinatal and pediatric outcomes are largely determined by the cause of hydrocephalus and the extent of the irreversible destruction of the brain tissue. In pregnancies where the fetal prognosis is unfavorable, aspirating the cerebrospinal fluid (CSF) to facilitate vaginal delivery is an option.

Efficacy of chlorhexidine wipes on colonization of and in both ventilator and nonventilator patients in pediatric intensive care unit.

Objective: In this coronavirus disease 2019 pandemic, pediatric children who are admitted in the intensive care unit (ICU) are more susceptible to ventilator-associated pneumonia. Ventilator-associated pneumonia is the second-most common hospital-acquired infection in pediatric ICU. Oral hygiene maintenance is a challenge here.

Priorities of desired functional recovery in Indian spinal cord injury patients.

Background: Spinal cord injuries (SCI) affect various functions and therefore the Quality of life (QOL) of these patients. Regaining even partial function can lead to improved QOL; making it crucial to know which functions are most important for these patients.

Material And Methods: This prompted us to conduct a survey in which subjects were asked to rank seven functions in order of importance to improve their quality of life.

Analysis of Different Polishing Systems on the Color Stability and Surface Roughness of Nanocomposite Resins.

Aim: To assess the different polishing systems on the color stability and surface roughness of nanocomposite resins.

Materials And Methods: A total of 60 composite resin samples were fabricated. The Tetric N Ceram composite was compacted into the custom-made cylindrical metallic mold of internal diameter 6 × 6 mm.