Clonal Hematopoiesis Is Associated with Increased Risk of Severe Neurotoxicity in Axicabtagene Ciloleucel Therapy of Large B-Cell Lymphoma.

Unlabelled: To explore the role of clonal hematopoiesis (CH) in chimeric antigen receptor (CAR) T-cell therapy outcomes, we performed targeted deep sequencing on buffy coats collected during the 21 days before lymphodepleting chemotherapy from 114 large B-cell lymphoma patients treated with anti-CD19 CAR T cells. We detected CH in 42 (36.8%) pretreatment samples, most frequently in PPM1D (19/114) and TP53 (13/114) genes.

X-ray Imaging of Functional Three-Dimensional Nanostructures on Massive Substrates.

To investigate the performance of three-dimensional (3D) nanostructures, it is vital to study their internal structure with a methodology that keeps the device fully functional and ready for further integration. To this aim, we introduce here traceless X-ray tomography (TXT) that combines synchrotron X-ray holographic tomography with high X-ray photon energies (17 keV) in order to study nanostructures "as is" on massive silicon substrates. The combined strengths of TXT are a large total sample size to field-of-view ratio and a large penetration depth.

A Comparative Evaluation of Mechanical Properties of Four Different Restorative Materials: An Study.

Objectives: The purpose of this study is to compare the mechanical properties (compressive strength (CS) and diametral tensile strength (DTS)) of four different restorative materials: conventional glass ionomer (Fuji IX), ClearFil AP-X, Filtex Z350-XT, and Cention N.

Materials And Methods: Specimens ( = 80) were prepared from Fuji IX, ClearFil AP-X, Filtex Z350-XT, and Cention N for testing compressive strength and DTS.

Statistical Analysis: Results obtained were subjected to one-way ANOVA and Tukey's test at significance ( < 0.

Venous malformations management by Er,Cr:YSGG laser: An Alternative approach.

Background And Aim: Venous malformations (VMs) are slow-flow vascular anomalies composed of ectatic venous channels. Its management with Er,Cr:YSGG laser has been proven effective. In the present case a teenage patient reported with a bluish lesion, soft inconsistency on the dorsal aspect of tongue.