Stability of an ophthalmic micellar formulation of cyclosporine A in unopened multidose eyedroppers and in simulated use conditions.

Cyclosporine A eye drops are used at concentrations ranging from 0.5 to 20mg/mL to treat a variety of ophthalmic diseases. Cyclosporine A formulations at high concentrations are difficult to manufacture because of cyclosporine's lipophilicity, and generally require an oil based vector.

[Musculoskeletal disorders: Role of medical advisers and inter-professional relations].

Introduction: Musculoskeletal disorders (MSD) were responsible for 9.7 million days of sick leave in 2010 in France. They are also a leading cause of occupational exclusion.

[Drug-drug interaction with telaprevir or boceprevir in liver transplant patients: about four cases].

Boceprevir and telaprevir are both direct-acting antivirals indicated, as part of combination therapy for the management of chronic hepatitis C virus (HCV) genotype 1 infection. Transplanted patients treated with anticalcineurines (tacrolimus and cyclosporine) are confronted with major risks of interactions. Indeed, these antiviral are strong inhibitors of the enzyme cytochrome 3A4/A5, responsible for the metabolisme of ciclosprine and tacrolimus.

Determination of terbinafine and its desmethyl metabolite in human plasma by high-performance liquid chromatography.

A reliable reversed-phase high-performance liquid chromatographic method has been developed for the determination of terbinafine (Terb) and its desmethyl metabolite (DMT) in human plasma. The analytes and the internal standard (I.S.

Fate and disposition of bromocriptine in animals and man. II: Absorption, elimination and metabolism.

The disposition and biotransformation of bromocriptine were investigated in mouse, rat, dog, rhesus monkey and man following administration of the drug substance labelled with either tritium or carbon-14. The enteral absorption of bromocriptine was incomplete and amounted to 30-40% of the dose as estimated directly from the sum of biliary and urinary excretion of radioactive compounds in bile duct cannulated rats and monkeys. The main route of elimination was the bile (80-93% of the absorbed dose).

Fate and disposition of bromocriptine in animals and man. I: structure elucidation of the metabolites.

A total of 16 metabolites of bromocriptine could be isolated from rat bile and incubates of rat liver cell preparations using [6-methyl-14C]bromocriptine as substrate. Separation and purification was achieved by reversed-phase liquid chromatography and preparative thin-layer chromatography in conjunction with radioactivity monitoring. Structure elucidation was based on spectroscopic data (UV, IR, NMR, EI- and FD-MS) and the results of amino acid analysis after acid hydrolysis.

An automated fluorimetric method for the determination of fluproquazone in plasma and urine.

A rapid and sensitive fluorimetric assay was developed for the quantitative determination of 4-(p-fluorophenyl)-1-isopropyl-7-methyl-2(1H)-quinazolinone(fluproquazone) in plasma and urine. The unchanged drug was extracted from alkalinized plasma or urine into n-heptane containing 0--1.5% isoamyl alcohol followed by a back extraction into 5 N HCl.