Contributions of Medical Greenhouse Gases to Climate Change and Their Possible Alternatives.

Considerable attention has recently been given to the contribution of the greenhouse gas (GHG) emissions of the healthcare sector to climate change. GHGs used in medical practice are regularly released into the atmosphere and contribute to elevations in global temperatures that produce detrimental effects on the environment and human health. Consequently, a comprehensive assessment of their global warming potential over 100 years (GWP) characteristics, and clinical uses, many of which have evaded scrutiny from policy makers due to their medical necessity, is needed.

Long-Lived Topological Flatband Excitons in Semiconductor Moiré Heterostructures: A Bosonic Kane-Mele Model Platform.

Moiré superlattices based on two-dimensional transition metal dichalcogenides (TMDs) have emerged as a highly versatile and fruitful platform for exploring correlated topological electronic phases. One of the most remarkable examples is the recently discovered fractional quantum anomalous Hall effect (FQAHE) under zero magnetic field. Here, we propose a minimal structure that hosts long-lived excitons-a ubiquitous bosonic excitation in TMD semiconductors-with narrow topological bosonic bands.

Neurotropic Murine β-Coronavirus Infection Causes Differential Expression of Connexin 47 in Oligodendrocyte Subpopulations Associated with Demyelination.

Gap junctions (GJs) play a crucial role in the survival of oligodendrocytes and myelination of the central nervous system (CNS). In this study, we investigated the spatiotemporal changes in the expression of oligodendroglial GJ protein connexin 47 (Cx47), its primary astroglial coupling partner, Cx43, and their association with demyelination following intracerebral infection with mouse hepatitis virus (MHV). Neurotropic strains of MHV, a β-coronavirus, induce an acute encephalomyelitis followed by a chronic demyelinating disease that shares similarities with the human disease multiple sclerosis (MS).

Eliashberg Theory for Dynamical Screening in Bilayer Exciton Condensation.

We study the effect of dynamical screening of interactions on the transition temperatures (T_{c}) of exciton condensation in a symmetric bilayer of quadratically dispersing electrons and holes by solving the linearized Eliashberg equations for the anomalous interlayer Green's functions. We find that T_{c} is finite for the range of density and layer separations studied, decaying exponentially with interlayer separation. T_{c} is suppressed well below that predicted by a Hartree Fock mean field theory with unscreened Coulomb interaction, but is above the estimates from the statically screened Coulomb interaction.

Machine Learning the Disorder Landscape of Majorana Nanowires.

We develop a practical machine learning approach to determine the disorder landscape of Majorana nanowires by using training of the conductance matrix and inverting the conductance data in order to obtain the disorder details in the system. The inversion carried out through machine learning using different disorder parametrizations turns out to be unique in the sense that any input tunnel conductance as a function of chemical potential and Zeeman energy can indeed be inverted to provide the correct disorder landscape. Our work opens up a qualitatively new direction of directly determining the topological invariant and the Majorana wave-function structure corresponding to a transport profile of a device using simulations that quantitatively match the specific conductance profile.

Engineering the Kitaev Spin Liquid in a Quantum Dot System.

The Kitaev model on a honeycomb lattice may provide a robust topological quantum memory platform, but finding a material that realizes the unique spin-liquid phase remains a considerable challenge. We demonstrate that an effective Kitaev Hamiltonian can arise from a half-filled Fermi-Hubbard Hamiltonian where each site can experience a magnetic field in a different direction. As such, we provide a method for realizing the Kitaev spin liquid on a single hexagonal plaquette made up of 12 quantum dots.

Nematic Excitonic Insulator in Transition Metal Dichalcogenide Moiré Heterobilayers.

We study the effect of interelectron Coulomb interactions on the displacement field induced topological phase transition in transition metal dichalcogenide moiré heterobilayers. We find a nematic excitonic insulator phase that breaks the moiré superlattice's threefold rotational symmetry and preempts the topological phase transition in both AA and AB stacked heterobilayers when the interlayer tunneling is weak, or when the Coulomb interaction is not strongly screened. The nematicity originates from the frustration between the nontrivial spatial structure of the interlayer tunneling, which is crucial to the existence of the topological Chern band, and the interlayer coherence induced by the Coulomb interaction that favors uniformity in layer pseudospin orientations.

Kondo Lattice Model in Magic-Angle Twisted Bilayer Graphene.

We systematically study emergent Kondo lattice models from magic-angle twisted bilayer graphene using the topological heavy fermion representation. At the commensurate fillings, we demonstrate a series of symmetric strongly correlated metallic states driven by the hybridization between a triangular lattice of SU(8) local moments and delocalized fermions. In particular, a (fragile) topological Dirac Kondo semimetal can be realized, providing a potential explanation for the symmetry-preserving correlated state at ν=0.

Dissipative Prethermal Discrete Time Crystal.

An ergodic system subjected to an external periodic drive will be generically heated to infinite temperature. However, if the applied frequency is larger than the typical energy scale of the local Hamiltonian, this heating stops during a prethermal period that extends exponentially with the frequency. During this prethermal period, the system may manifest an emergent symmetry that, if spontaneously broken, will produce subharmonic oscillation of the discrete time crystal (DTC).

Genomic Analysis of Haloarchaea from Diverse Environments, including Permian Halite, Reveals Diversity of Ultraviolet Radiation Survival and DNA Photolyase Gene Variants.

Ultraviolet (UV) radiation responses of extremophilic and archaeal microorganisms are of interest from evolutionary, physiological, and astrobiological perspectives. Previous studies determined that the halophilic archaeon, sp. NRC-1, which survives in multiple extremes, is highly tolerant of UV radiation.

Effects of Salinity and Temperature on the Flexibility and Function of a Polyextremophilic Enzyme.

The polyextremophilic β-galactosidase enzyme of the haloarchaeon functions in extremely cold and hypersaline conditions. To better understand the basis of polyextremophilic activity, the enzyme was studied using steady-state kinetics and molecular dynamics at temperatures ranging from 10 °C to 50 °C and salt concentrations from 1 M to 4 M KCl. Kinetic analysis showed that while catalytic efficiency (/) improves with increasing temperature and salinity, is reduced with decreasing temperatures and increasing salinity, consistent with improved substrate binding at low temperatures.

Topological Phases in AB-Stacked MoTe_{2}/WSe_{2}: Z_{2} Topological Insulators, Chern Insulators, and Topological Charge Density Waves.

We present a theory on the quantum phase diagram of AB-stacked MoTe_{2}/WSe_{2} using a self-consistent Hartree-Fock calculation performed in the plane-wave basis, motivated by the observation of topological states in this system. At filling factor ν=2 (two holes per moiré unit cell), Coulomb interaction can stabilize a Z_{2} topological insulator by opening a charge gap. At ν=1, the interaction induces three classes of competing states, spin density wave states, an in-plane ferromagnetic state, and a valley polarized state, which undergo first-order phase transitions tuned by an out-of-plane displacement field.

Fermionic Many-Body Localization for Random and Quasiperiodic Systems in the Presence of Short- and Long-Range Interactions.

We study many-body localization (MBL) for interacting one-dimensional lattice fermions in random (Anderson) and quasiperiodic (Aubry-Andre) models, focusing on the role of interaction range. We obtain the MBL quantum phase diagrams by calculating the experimentally relevant inverse participation ratio (IPR) at half-filling using exact diagonalization methods and extrapolating to the infinite system size. For short-range interactions, our results produce in the phase diagram a qualitative symmetry between weak and strong interaction limits.

Bioengineering of Halobacterium sp. NRC-1 gas vesicle nanoparticles with GvpC fusion protein produced in E. coli.

Gas vesicle nanoparticles (GVNPs) are hollow, buoyant prokaryotic organelles used for cell flotation. GVNPs are encoded by a large gas vesicle protein (gvp) gene cluster in the haloarchaeon, Halobacterium sp. NRC-1, including one gene, gvpC, specifying a protein bound to the surface of the nanoparticles.

Genome Sequence of the Early 20th-Century Extreme Halophile sp. Strain NRC-34001.

sp. strain NRC-34001 is a red, extremely halophilic archaeon isolated in Canada in 1934. Single-molecule real-time sequencing revealed a 2.

Double mutations far from the active site affect cold activity in an Antarctic halophilic β-galactosidase.

The Antarctic haloarchaeon, Halorubrum lacusprofundi, contains a polyextremophilic family 42 β-galactosidase, which we are using as a model for cold-active enzymes. Divergent amino acid residues in this 78 kDa protein were identified through comparative genomics and hypothesized to be important for cold activity. Six amino acid residues were previously mutated and five were shown by steady-state kinetic analysis to have altered temperature-dependent catalytic activity profiles via effects on K and/or k compared to the wild-type enzyme.

Correlation-Induced Triplet Pairing Superconductivity in Graphene-Based Moiré Systems.

Motivated by the possible non-spin-singlet superconductivity in the magic-angle twisted trilayer graphene experiment, we investigate the triplet-pairing superconductivity arising from a correlation-induced spin-fermion model of Dirac fermions with spin, valley, and sublattice degrees of freedom. We find that the f-wave pairing is favored due to the valley-sublattice structure, and the superconducting state is time-reversal symmetric, fully gapped, and nontopological. With a small in-plane magnetic field, the superconducting state becomes partially polarized, and the transition temperature can be slightly enhanced.

Genome Sequence of sp. Strain BOL4-2, Isolated and Cultured from Salar de Uyuni, Bolivia.

sp. strain BOL4-2 was isolated from an Andean salt flat, Salar de Uyuni, in Bolivia. Single-molecule real-time (SMRT) sequencing revealed a 2.

Acoustic-Phonon-Mediated Superconductivity in Rhombohedral Trilayer Graphene.

Motivated by the observation of two distinct superconducting phases in the moiréless ABC-stacked rhombohedral trilayer graphene, we investigate the electron-acoustic-phonon coupling as a possible pairing mechanism. We predict the existence of superconductivity with the highest T_{c}∼3  K near the Van Hove singularity. Away from the Van Hove singularity, T_{c} remains finite in a wide range of doping.

Interaction-Driven Filling-Induced Metal-Insulator Transitions in 2D Moiré Lattices.

Using a realistic band structure for twisted WSe_{2} materials, we develop a theory for the interaction-driven correlated insulators to conducting metals transitions through the tuning of the filling factor around commensurate fractional fillings of the moiré unit cell in the 2D honeycomb lattice, focusing on the dominant half-filled Mott insulating state, which exists for both long- and short-range interactions. We find metallic states slightly away from half-filling, as have recently been observed experimentally. We discuss the stabilities and the magnetic properties of the resulting insulating and metallic phases, and comment on their experimental signatures.

Complete Genome and Methylome Analysis of the Box-Shaped Halophilic Archaeon Haloarcula sinaiiensis ATCC 33800.

The genome of halophilic archaeon Haloarcula sinaiiensis ATCC 33800 was sequenced and assembled and comprises seven replicons. Four m6A and one m4C modified motifs and their responsible methyltransferase genes have been identified in the genome by single-molecule real-time (SMRT) sequencing and bioinformatic analysis.

Anomalous Floquet Chiral Topological Superconductivity in a Topological Insulator Sandwich Structure.

We show that Floquet chiral topological superconductivity arises naturally in Josephson junctions made of magnetic topological insulator-superconductor sandwich structures. The Josephson phase modulation associated with an applied bias voltage across the junction drives the system into the anomalous Floquet chiral topological superconductor hosting chiral Majorana edge modes in the quasienergy spectrum, with the bulk Floquet bands carrying zero Chern numbers. The bias voltage acts as a tuning parameter enabling novel Floquet topological quantum phase transitions driving the system into a myriad of exotic Majorana-carrying Floquet topological superconducting phases.