The analysis of the RBL-STEM application in improving student financial literacy in controlling consumptive behavior.

This study aims to analyze the application of the RBL-STEM learning model in improving students' financial literacy to control their consumptive behavior. The method used in this study combines qualitative and quantitative methods by involving 110 students of Riau University. The data of this study were analyzed using SEM PLS on nine Hypotheses that link the application of the RBL-STEM model, student literacy, and student consumptive behavior.

Local Multiset Dimension of Amalgamation Graphs.

: One of the topics of distance in graphs is the resolving set problem. Suppose the set = { , , …, } ⊂ ( ), the vertex representations of ∈ ( ) is ( | ) = { ( , ), ( , ), …, ( , )}, where ( , ) is the length of the shortest path of the vertex and the vertex in together with their multiplicity. The set is called a local -resolving set of graphs if ( | )≠ ( | ) for ∈ ( ).

The analysis of the implementation of RBL-STEM learning materials in improving student's meta-literacy ability to solve wallpaper decoration problems using local antimagic graph coloring techniques.

The tessellation problem is interesting to study, especially when it is associated with mathematical concepts. In this study, a graph coloring technique will be applied to solve the problem of wallpaper tessellation decoration. The main objective of this study is to improve students' meta-literacy abilities when applying coloring techniques in completing tessellation wallpaper decorations in RBL-STEM learning.

The reflexive edge strength on some almost regular graphs.

A function with domain and range are respectively the edge set of graph and natural number up to , and a function with domain and range are respectively the vertex set of graph and the even natural number up to are called a total -labeling where . The total -labeling of graph by the condition that every two different edges have different weight is called an edge irregular reflexive -labeling, where for any edge , the weight is . The reflexive edge strength of the graph , denoted by is the minimum for graph which has an edge irregular reflexive -labelling.

CYP3A4-catalyzed simvastatin metabolism as a non-invasive marker of small intestinal health in celiac disease.

Objectives: Histological examination of duodenal biopsies is the gold standard for assessing intestinal damage in celiac disease (CD). A noninvasive marker of disease status is necessary, because obtaining duodenal biopsies is invasive and not suitable for routine monitoring of CD patients. As the small intestine is a major site of cytochrome P450 3A4 (CYP3A4) activity and also the location of the celiac lesion, we investigated whether patients with active CD display abnormal pharmacokinetics of an orally administered CYP3A4 substrate, simvastatin (SV), which could potentially be used for noninvasive assessment of their small intestinal health.

Anti-Oligomannose Antibodies as Potential Serum Biomarkers of Aggressive Prostate Cancer.

[Table: see text] This study bridges a carbohydrate microarray discovery and a large-scale serological validation of anti-oligomannose antibodies as novel serum biomarkers of aggressive prostate cancer (PCa). Experimentally, a Man9-cluster-specific enzyme-linked immunosorbent assay was established to enable sensitive detection of anti-Man9 antibodies in human sera. A large-cohort of men with PCa or benign prostatic hyperplasia (BPH) whose sera were banked at Stanford University was characterized using this assay.

Gα(h)/transglutaminase-2 activity is required for maximal activation of adenylylcyclase 8 in human and rat glioma cells.

Gα(h) (or transglutaminase-2 (TG2)) is an atypical guanine nucleotide binding-protein that associates with G protein-coupled receptors. TG2 also exerts transglutaminase activity that catalyzes posttranslational protein cross-linking with the formation of ε-(γ-glutamyl) lysine or (γ-glutamyl) polyamine bonds. Here, the role of Gα(h)/TG2 in signal transduction in glial cells was examined in detail.

Activation and inhibition of transglutaminase 2 in mice.

Transglutaminase 2 (TG2) is an allosterically regulated enzyme with transamidating, deamidating and cell signaling activities. It is thought to catalyze sequence-specific deamidation of dietary gluten peptides in the small intestines of celiac disease patients. Because this modification has profound consequences for disease pathogenesis, there is considerable interest in the design of small molecule TG2 inhibitors.

Dihydroisoxazole analogs for labeling and visualization of catalytically active transglutaminase 2.

We report the synthesis and preliminary characterization of "clickable" inhibitors of human transglutaminase 2 (TG2). These inhibitors possess the 3-halo-4,5-dihydroisoxazole warhead along with bioorthogonal groups such as azide or alkyne moieties that enable subsequent covalent modification with fluorophores. Their mechanism for inhibition of TG2 is based on halide displacement, resulting in the formation of a stable imino thioether.

Modulation of cellular adhesion by glycoengineering.

Aberrant glycosylation of lipid and protein molecules on cellular surfaces is responsible for many of the pathophysiological events in tumor progression and metastasis. Sialic acids in particular, are overexpressed on the glycocalyx of malignant tumor cells and sialic acid-mediated cell adhesion is required for metastasis. We report here that replacement of sialic acids on cell surfaces with fluorinated congeners dramatically decreases cell adhesion to E- and P-selectin-coated surfaces.

Fluorinated lipid constructs permit facile passage of molecular cargo into living cells.

Fluorinated lipids get rapidly internalized into living cells and are also displayed on the cell surface. The uptake of lipids is energy dependent and is likely via the clathrin-mediated endocytic pathway. Fluorinated lipids are 3-5-fold more efficient in acting as molecular transporters of noncovalently bound proteins than their hydrocarbon counterparts.

Fluorination of mammalian cell surfaces via the sialic acid biosynthetic pathway.

Metabolic oligosaccharide engineering has been employed to introduce fluorine-containing groups onto mammalian cell surfaces. Incubation of HeLa, Jurkat, and HL60 cells in culture with fluorinated sialic acid and mannosamine analogues resulted in cell-surface presentation of fluorinated glycans. Metabolic conversion of fluorinated precursors was detected and quantified by DMB-derivatization and HPLC ESI-MS analysis.

Bioorthogonal noncovalent chemistry: Fluorous phases in chemical biology.

Chemical entities designed to noncovalently interact with predetermined partners have fashioned a new paradigm in chemical biology. Fluorocarbons are extremely promising as supramolecular synthons toward these objectives. Bioorthogonal noncovalent interactions provide a way to modulate self-assembled systems in environments where such control has hitherto not been possible.