Exosomes derived from syncytia induced by SARS-2-S promote the proliferation and metastasis of hepatocellular carcinoma cells.

Introduction: Coronavirus disease 2019 (COVID-19) is characterized by fever, fatigue, dry cough, dyspnea, mild pneumonia and acute lung injury (ALI), which can lead to acute respiratory distress syndrome (ARDS), and SARS-CoV-2 can accelerate tumor progression. However, the molecular mechanism for the increased mortality in cancer patients infected with COVID-19 is unclear.

Methods: Colony formation and wound healing assays were performed on Huh-7 cells cocultured with syncytia.

The effect of immunosuppression on outcomes in elderly patients with community-acquired pneumonia.

Background: The effect of immunosuppression on clinical manifestations and outcomes was unclear in elderly patients with CAP.

Methods: Elderly hospitalised patients with CAP were consecutively enrolled and were divided into immunocompromised hosts (ICHs) or non-ICHs groups. Clinical manifestations, severity, and outcomes were compared.

Prevalence of malnutrition among adult inpatients in China: a nationwide cross-sectional study.

Malnutrition substantially contributes to adverse clinical outcomes. However, no national survey has been conducted to characterize its epidemiology in hospital settings in China. We conducted the China Nutrition Fundamental Data 2020 project among a multistage stratified cluster sample of adult inpatients from 291 study sites across 30 provinces, autonomous regions and municipalities (except for Hong Kong, Macao, Taiwan Province, and the Xizang Autonomous Region, please see MATERIALS AND METHODS for details of the causes) of China to generate reliable data on the prevalence of malnutrition and explore the associated risk factors.

Why do patients with isolated PCL rupture experience no subjective knee joint instability during walking? An biomechanical study.

Objective: The aim of this study is to assess the kinematic changes in the knee joint during walking in patients with isolated PCL-deficiency (PCLD) to determine the presence of walking-related joint instability (mechanical instability-abnormal displacement form structural damage). Additionally, the study seeks to provide biomechanical insights into the observed differences between subjective and objective assessments.

Methods: 35 healthy volunteers and 27 patients with isolated PCLD (both involved and uninvolved sides) were included in the study.

Functional Connectivity Alterations Associated with COVID-19-Related Sleep Problems: A Longitudinal Resting-State fMRI Study.

Background: COVID-19 has led to reports of fatigue and sleep problems. Brain function changes underlying sleep problems (SP) post-COVID-19 are unclear.

Purpose: This study investigated SP-related brain functional connectivity (FC) alterations.

Thrombolytic therapy for patients with acute ischemic stroke: systematic review and network meta-analysis of randomized trials.

Objective: To systematically compare the benefits and risks of all thrombolytic agents (tenecteplase, reteplase, and alteplase) at different doses for thrombolytic therapy in patients with acute ischemic stroke (AIS).

Background: Alteplase is the cornerstone treatment for AIS, but alternative thrombolytic agents are needed. The efficacy and safety of tenecteplase and reteplase, compared to alteplase, remain unclear, as does the optimal dosing for these treatments.

A double probe-based fluorescence sensor array to detect rare earth element ions.

There is a persistent need for effective sensors to detect rare earth element ions (REEIs) due to their effects on human health and the environment. Thus, a simple and efficient fluorescence-based detection method for REEIs that offers convenience, flexibility, versatility, and efficiency is essential for ensuring environmental safety, food quality, and biomedical applications. In this study, 6-aza-2-thiothymine-gold nanoclusters (ATT-AuNCs) and bovine serum albumin/3-mercaptopropionic acid-AuNCs (BSA/MPA-AuNCs) were utilized to detect 14 REEIs (Sc, Gd, Lu, Y, Ce, Pr, Yb, Dy, Tm, Sm, Ho, Tb, La, and Eu), resulting in the creation of a simple, sensitive, and multi-target fluorescence sensor array detection platform.

College students' entrepreneurship education path and management strategy of start-up enterprises using causal attribution theory.

The current social entrepreneurship situation is not ideal. This study aims to enhance the effectiveness of college students' entrepreneurship education and improve the safety factor of start-up enterprises. Firstly, the current situation of college students' entrepreneurship education is studied through questionnaires and literature review.

Enhanced solar hydrogen production via reconfigured semi-polar facet/cocatalyst heterointerfaces in GaN/Si photocathodes.

The development of an efficient and durable photoelectrode is critical for achieving large-scale applications in photoelectrochemical water splitting. Here, we report a unique photoelectrode composed of reconfigured gallium nitride nanowire-on-silicon wafer loaded with Au nanoparticles as cocatalyst that achieved an impressive applied bias photon-to-current efficiency of 10.36% under AM 1.

Single-cell mitophagy patterns within the tumor microenvironment modulate intercellular communication, impacting the progression and prognosis of hepatocellular carcinoma.

Background: Hepatocellular carcinoma (HCC) is a common malignant tumor of the digestive system with a high incidence that seriously threatens patients' lives and health. However, with the rise and application of new treatments, such as immunotherapy, there are still some restrictions in the treatment and diagnosis of HCC, and the therapeutic effects on patients are not ideal.

Methods: Two single-cell RNA sequencing (scRNA-seq) datasets from HCC patients, encompassing 25,189 cells, were analyzed in the study.

Revealing the role of cancer-associated fibroblast senescence in prognosis and immune landscape in pancreatic cancer.

Cancer-associated fibroblasts (CAFs) represent a major contributor to tumor growth. Cellular senescence is a state of cell-cycle arrest characterized by a pro-inflammatory phenotype. The potential impact of CAF senescence on tumor progression and the tumor microenvironment (TME) remains to be elucidated.

Effects of dapagliflozin on heart rate variability, cardiac function, and short-term prognosis in early-onset post-myocardial infarction heart failure.

Objective: To investigate the effects of dapagliflozin, in addition to standard therapy, on heart rate variability (HRV), soluble growth stimulation expressed gene 2 protein (sST2), N-terminal pro B-type natriuretic peptide (NT-proBNP), and echocardiographic parameters in patients with early-onset post-myocardial infarction heart failure (HF).

Methods: A total of 98 patients with early-onset post-myocardial infarction HF were enrolled and randomly divided into a control group ( = 48, receiving standard therapy) and an observation group ( = 50, receiving standard therapy plus dapagliflozin 10 mg daily). HRV, cardiac function, and echocardiographic parameters were measured at baseline and after 24 weeks of treatment.

Hyperosmotic stress-induced NLRP3 inflammasome activation via the mechanosensitive PIEZO1 channel in dry eye corneal epithelium.

Unlabelled: The activation of the NLRP3 inflammasome by hyperosmotic stress is a critical pathophysiological response in dry eye disease (DED), driving the chronic cycle of inflammation on the ocular surface. The specific mechanism underlying hyperosmotic mechanical stimulation activates the NLRP3 inflammasome remains unclear. This study provides evidence that PIEZO1, a mechanosensitive ion channel, functions as the primary receptor for corneal epithelial cells in sensing mechanical stimulation induced by tear hyperosmolarity.

Clinicopathological characteristics and prognosis of lupus nephritis patients with positive anti-ribonucleoprotein antibodies.

Background: Positive anti-ribonucleoprotein antibodies may characterize a subgroup of patients affected by lupus nephritis with mild kidney damage, but little is known about their clinical features and long-term prognosis.

Methods: Patients were retrospectively selected from the lupus nephritis database ( http://ln.medidata.

Pinnatifone A, isolated from Syringa pinnatifolia (Oleaceae), exhibits inhibitory activity against phytopathogenic fungi and can be employed to formulate a soluble concentrate agent.

Background: In the realm of plant diseases, those caused by fungi and oomycetes are particularly challenging to manage, resulting in significant economic losses. There exist diverse active substances in natural products and developing them into fungicides holds great significance. At the initial phase of our research, we discovered that Syringa pinnatifolia extract demonstrates broad-spectrum inhibitory activity against phytopathogenic fungi.

Vascular flow alteration is a dominant pattern of liver pathology in patients with orthotopic lung transplants: a retrospective observational study.

Aims: The number of orthotopic lung transplants (OLT) has skyrocketed since the 1960s, generating an ever-increasing cohort of post-OLT patients. Many challenges exist in the post-OLT timeframe, including donor graft dysfunction, infection, malignancy, and immunosuppression-related conditions. A rather elusive topic in the posttransplant setting remains the impact of the underlying disease process and donor lungs on other organ systems and the complications arising from the complex physiologic interactions.

A Prospective Self-Controlled Study on the Alterations of the Ocular Surface and Conjunctival Transcriptomic Profile Associated with Prolonged Exposure to Video Display Terminals.

Purpose: To assess the impact of prolonged and intense exposure to video display terminals (VDTs) on ocular surface homeostasis.

Methods: 30 subjects limited daily VDT usage to less than 3 hours for one week, then extended usage to more than 8 hours/day for the next three weeks. Ocular symptoms and signs were evaluated weekly using the Ocular Surface Disease Index (OSDI) questionnaire and clinical examinations.

A wheat phytohormone atlas spanning major tissues across the entire life cycle provides novel insights into cytokinin and jasmonic acid interplay.

Although numerous studies have focused on the specific organs or tissues at different development stages or under various abiotic and biotic stress, our understanding of the distribution and relative abundance of phytohormones throughout the entire life cycle of plant organs and tissues remains insufficient. Here, we present a phytohormone atlas resource covering the quantitative analysis of eight major classes of phytohormones, comprising a total of 40 hormone-related compounds, throughout the complete life cycle of wheat. In combination with transcriptome analysis, we established a Wheat Phytohormone Metabolic Regulatory Network (WPMRN).

Construction of the bromodomain-containing protein-associated prognostic model in triple-negative breast cancer.

Background: Bromodomain-containing protein (BRD) play a pivotal role in the development and progression of malignant tumours. This study aims to identify prognostic genes linked to BRD-related genes (BRDRGs) in patients with triple-negative breast cancer (TNBC) and to construct a novel prognostic model.

Methods: Data from TCGA-TNBC, GSE135565, and GSE161529 were retrieved from public databases.

Versatile platforms of mussel-inspired agarose scaffold for cell cultured meat.

Introduction: Biomaterial scaffolds are critical for cell cultured meat production. polysaccharide scaffolds lack essential animal cell adhesion receptors, leading to significant challenges in cell proliferation and myogenic differentiation. Thus, enhancing cell adhesion and growth on polysaccharide scaffolds is strongly required to supply the gaps in cell-cultured meat production.

Deciphering and Enhancing Rate-Determining Step of Sodium Deposition towards Ultralow-Temperature Sodium Metal Batteries.

Achieving high ionic conductivity and stable performance at low temperatures remains a significant challenge in sodium-metal batteries (SMBs). In this study, we propose a novel electrolyte design strategy that elucidates the solvation structure-function relationship within mixed solvent systems. A mixture of diglyme and 1,3-dioxolane was developed to optimize the solvation structure towards superior low-temperature electrolyte.

Deltacoronavirus HKU11, HKU13, PDCoV (HKU15) and HKU17 spike pseudoviruses enter avian DF-1 cells via clathrin-mediated endocytosis in a Rab5-, Rab7- and pH-dependent manner.

Porcine deltacoronavirus (PDCoV), also known as HKU15, is a swine enteropathogenic virus that is believed to have originated in birds. PDCoV belongs to the genus Deltacoronavirus (DCoV), the members of which have mostly been identified in diverse avian species. We recently reported that chicken or porcine aminopeptidase N (APN), the major cellular receptor for PDCoV, can mediate cellular entry via three pseudotyped retroviruses displaying spike proteins from three avian DCoVs (HKU11, HKU13, and HKU17).

Abnormal sensory processing cortex in insomnia disorder: a degree centrality study.

Insomnia disorder is a significant global health concern. This research aimed to explore the pathogenesis of insomnia disorder using static and dynamic degree centrality methods at the voxel level. A total of 29 patients diagnosed with insomnia disorder and 28 healthy controls were ultimately included to examine differences in degree centrality between the two groups.

A retrospective multicenter study on the efficacy and safety of disitamab vedotin monotherapy versus combination with anti-PD-1 immunotherapy in advanced gastric cancer.

Novel therapeutic agents including disitamab vedotin (RC48, an antibody-drug conjugate) and immune-checkpoint inhibitors (e.g., PD-1 inhibitors) have provided new hope as an advanced gastric-cancer (GC) treatment.

Uniaxial compressive damage evolution and constitutive modeling of fissure-like rocks under different loading rates based on acoustic emission.

In natural environments, most rocks possess internal fissures and are often exposed to diverse external loads arising from engineering activities and ground stress, among other factors. This study aims to explore the influence of different loading rates on the mechanical properties and acoustic emission (AE) characteristics of fissured rocks and to develop an intrinsic damage model. To achieve this, prefabricated fissured rock specimens that mimic natural rocks were prepared.