Comparison of Single Knee Arthroplasty and Bilateral Knee Arthroplasty in Haemophiliacs During a Single Operation: A Systematic Review and Meta-Analysis.

Background: Arthroplasty is the standard treatment for end-stage haemophilic knee arthritis; however, the choice between single knee arthroplasty (SKA) and bilateral knee arthroplasty (BKA) in a single operation remains controversial due to the risks specific to haemophiliacs.

Methods: Two independent researchers conducted searches across CNKI, CBM, Wanfang, PubMed, Cochrane Library, Embase, and Web of Science, with the last search performed on 15 October 2024. Study results include joint function, complication and various cost.

Acid-Triggered Dual-Functional Hydrogel Platform for Enhanced Bone Regeneration.

Stem cell implantation holds promise for enhancing bone repair, but risks of pathogen transmission and malignant cell transformation should not be ignored. Compared to stem cell implantation, recruitment of endogenous stem cells to injured sites is more critical for in situ bone regeneration. In this study, based on the acidic microenvironment of bone injury, an HG-AA-SDF-1α composite hydrogel with a dual-control intelligent switch function is developed by incorporating stromal cell-derived factor (SDF-1α), arginine carbon dots (Arg-CDs), and calcium ions (Ca) into the oxidized hyaluronic acid/gelatin methacryloyl (HG) hydrogel.

Psoralen and Isopsoralen Activate Nuclear Factor Erythroid 2-Related Factor 2 Through Interaction With Kelch-Like ECH-Associated Protein 1.

As natural furocoumarins, psoralen and its isomer isopsoralen are widely distributed in various fruits including L., vegetables including celery, and medicinal herbs including L. Although psoralen and isopsoralen have been used as dietary supplements because of their bioactivities such as antibacterial and anti-inflammatory properties; however, the potential mechanisms underlying the antioxidant activities of these two furocoumarins still need to be explored.

Efficient luminescent solar concentrators based on solvent polarity induced multiple-colored carbon dots.

Luminescent solar concentrators (LSCs) are large scale sunlight collector and can be used for building-integrated photovoltaics (BIPV). Achieving high-performance LSCs requires fluorophores with broad absorption, high quantum yield and a large Stokes shift. Nevertheless, conventional high-efficiency LSCs typically rely on heavy metal-based quantum dots as fluorophores.

Effect of Combined Urea and Calcium Nitrate Application on Wheat Tiller Development, Nitrogen Use Efficiency, and Grain Yield.

Optimizing nitrogen (N) sources has the potential to improve wheat tillering, nitrogen use efficiency (NUE), and grain yield, yet the underlying mechanisms remain unclear. This study hypothesizes that combining specific N sources can increase zeatin riboside + zeatin (ZR + ZT) content in tiller nodes and maintain a higher ZR + ZT/gibberellin A7 (GA) ratio, thereby promoting tiller development, enhancing NUE, and increasing yield. The effects of N source treatments on two wheat cultivars, the multi-spike Shannong 28 (SN28) and the large-spike Tainong 18 (TN18), were investigated.

Research on the Estimation Model of Electrical Parameters of Silver-Based Contacts Based on Surface Morphology.

The quality of surface morphology can reflect the electrical performance of silver-based contacts. Existing research on the correlation of morphological-electrical performance is based solely on empirical models from traditional visual inspections and only considers the impact of visually observable macro-textural features on electrical performance. However, the influence of micro-textural features on electrical performance should not be overlooked.

Cell-to-Cell Natural Transformation Mediated Efficient Plasmid Transfer Between Species.

Horizontal gene transfer (HGT) plays a pivotal role in bacterial evolution, shaping the genetic diversity of bacterial populations. It can occur through mechanisms such as conjugation, transduction, and natural transformation. , a model Gram-positive bacterium, serves not only as a robust system for studying HGT but also as a versatile organism with established industrial applications, such as producing industrial enzymes, antibiotics, and essential metabolites.

Effects of Different Levels of Flavonoids on Growth Performance, Immunity, Intestinal Barrier and Antioxidant Capacity of Meat Ducks.

In vitro findings on the biological functions of Lycium barbarum flavonoids (LBFs) as feed additives are limited. This study aimed to explore the effects of different concentrations of LBFs on the growth performance, immune function, intestinal barrier, and antioxidant capacity of meat ducks. A total of 240 one-day-old male meat ducks were randomly allocated to four groups, each receiving a basal diet supplemented with 0 (control), 250, 500, or 1000 mg/kg of LBFs for 42 d.

An MDR Salmonella Enteritidis sublineage associated with gastroenteritis outbreaks and invasive disease in China.

Objectives: Salmonella enterica serovar Enteritidis (S. Enteritidis) is a commonly reported pathogen which adapts to multiple hosts and causes critical disease burden at a global level. Here, we investigated a recently derived epidemic sublineage with multidrug resistance (MDR), which have caused extended time-period and cross-regional gastroenteritis outbreaks and even invasive nontyphoidal Salmonella disease (iNTS) in China.

Deep soil contributions to global nitrogen budgets.

Previous estimates of deep soil inorganic nitrogen (N) reservoirs have been mainly limited to desert soils, however, recent evidence suggests that deep soil pools are far more ubiquitous across biomes and therefore may be important for global N budgets. Here, we used observations from 280 deep soil profiles (2-205 m) across a wide array of ecosystem and land cover types to seek insight into the full geospatial variation of deep soil nitrate. Using a random forest machine learning approach we estimate a total deep soil nitrate pool of 15.

Hydrophobic driving fabrication of highly dispersed PtNi in Zr-doped 3D hollow flower-like MgAlO spheres with abundant O vacancies for enhanced dry reforming of methane.

The dry reforming of methane (DRM) could convert CH and CO into syngas, offering potential for greenhouse gas mitigation. However, DRM catalyst sintering and carbon deposition remain major obstacles. In this study, a highly dispersed PtNi alloy@Zr-doped 3D hollow flower-like MgAlO (AMO) spheres was prepared through a hydrophobic driving strategy.

A global overview of shared genetic architecture between smoking behaviors and major depressive disorder in European and East Asian ancestry.

Background: The co-occurrence of smoking behaviors and major depressive disorder (MDD) has been widely documented in populations. However, the underlying mechanism of this association remains unclear.

Methods: Genome-wide association studies of smoking behaviors and MDD, combined with multi-omics datasets, were usedto characterise genetic correlations, identify shared loci and genes, and explore underlying biological mechanisms.

Ribosomal protein L6 suppresses hepatocellular carcinoma by modulating FBXO22-mediated p53 degradation.

The ribosomal protein L6 (RPL6) is significant in the progression of different cancer types. However, its precise role in hepatocellular carcinoma (HCC) remains unclear. This research demonstrated that the expression levels of RPL6 are notably decreased in HCC tissues.

The GlnE protein of Azorhizobium caulinodans ORS571 plays a crucial role in the nodulation process of the legume host Sesbania rostrata.

The GlnE enzyme, functioning as an adenylyltransferase/adenylyl-removing enzyme, plays a crucial role in reversible adenylylation of glutamine synthetase (GS), which in turn regulates bacterial nitrogen assimilation. Genomic analysis of Azorhizobium caulinodans ORS571 revealed an open reading frame encoding a GlnE protein, whose function in the free-living and symbiotic states remains to be elucidated. A glnE deletion mutant retained high GS activity even under nitrogen-rich conditions.

Association between obstructive sleep apnea and Tinnitus in the United States: NHANES 2005-2020.

Background: This study aimed to investigate the association between Obstructive Sleep Apnea (OSA) and Tinnitus using NHANES data from 2005 to 2020.

Methods: This study analyzed data from NHANES (National Health and Nutrition Examination Surveys) conducted between 2005 and 2020, and included 4871 participants aged 16 or older. OSA was assessed using the Multivariate Apnea Prediction Index and the variables from the National Health and Nutrition Examination Survey.

The first multiple center prospective study of rhFSH CTP in patients undergoing assisted reproductive technology in China.

We assessed the safety and efficacy of rhFSH-CTP, a novel long-acting FSH agent, in controlled ovarian hyperstimulation for patients undergoing ART. A multi-center, open-label, randomized, positive-control, non-inferiority clinical trial was conducted. The study consisted of a phase III randomized design, with a 1:1 ratio favoring the rhFSH-CTP group over the control group.

Enhanced solar hydrogen production via reconfigured semi-polar facet/cocatalyst heterointerfaces in GaN/Si photocathodes.

The development of an efficient and durable photoelectrode is critical for achieving large-scale applications in photoelectrochemical water splitting. Here, we report a unique photoelectrode composed of reconfigured gallium nitride nanowire-on-silicon wafer loaded with Au nanoparticles as cocatalyst that achieved an impressive applied bias photon-to-current efficiency of 10.36% under AM 1.

Understanding the Glycosylation Pathways Involved in the Biosynthesis of the Sulfated Glycan Ligands for Siglecs.

Carbohydrate sulfation plays a pivotal role in modulating the strength of Siglec-glycan interactions. Recently, new aspects of Siglec binding to sulfated cell surface carbohydrates have been discovered, but the class of glycan presenting these sulfated Siglec ligands has not been fully elucidated. In this study, the contribution of different classes of glycans to and Siglec ligands was investigated within cells expressing the carbohydrate sulfotransferase 1 (CHST1) or CHST2.

The PurR family transcriptional regulator promotes butenyl-spinosyn production in Saccharopolyspora pogona.

Butenyl-spinosyn, derived from Saccharopolyspora pogona, is a broad-spectrum and effective bioinsecticide. However, the regulatory mechanism affecting butenyl-spinosyn synthesis has not been fully elucidated, which hindered the improvement of production. Here, a high-production strain S.

SCARB1 links cholesterol metabolism-mediated ferroptosis inhibition to radioresistance in tumor cells.

Introduction: Ferroptosis is an iron-dependent form of cell death triggered by the excessive accumulation of lipid peroxides. Understanding the regulatory mechanisms of ferroptosis and developing strategies to target this process hold significant clinical applications in tumor therapy.

Objective: Our study aims to search for novel candidate genes involved in the regulation of ferroptosis and to investigate their mechanism of action in ferroptosis and tumor therapy.

Methane oxidation to ethanol by a molecular junction photocatalyst.

Methane, the major component of natural and shale gas, is a significant carbon source for chemical synthesis. The direct partial oxidation of methane to liquid oxygenates under mild conditions is an attractive pathway, but the molecule's inertness makes it challenging to achieve simultaneously high conversion and high selectivity towards a single target product. This difficulty is amplified when aiming for more valuable products that require C-C coupling.

Mechanistic Insights into the Effects of Aged Polystyrene Nanoplastics on the Toxicity of Cadmium to Triticum Aestivum.

The widespread concern over nanoplastics (NPs) has prompted extensive research into their environmental impact. Concurrently, the study examined the combined toxicity of PS NPs and cadmium (Cd) on wheat. As indicated by the results of in situ Micro-ATR/FTIR, the aging process of PS NPs (50 nm) led to an increase in carbonyl and hydroxyl groups on their surface, enhancing hydrophilicity and consequently, the adsorption capacity for Cd.

Efficacy, safety and cost-effectiveness of obinutuzumab in patients with follicular lymphoma: a rapid review.

Background: Obinutuzumab was approved in China in June 2021 used in combination with chemotherapy (followed by obinutuzumab maintenance) for the treatment of adult patients with previously untreated stage II bulky, III, or IV follicular lymphoma (FL). The clinical application of obinutuzumab has recently begun in China, but there is a lack of evidence to determine under which circumstances it should be considered the treatment of choice. A comprehensive assessment is necessary to evaluate the efficacy, safety, and cost-effectiveness of obinutuzumab in adult patients with FL.

Soil microbial carbon use efficiency differs between mycorrhizal trees: insights from substrate stoichiometry and microbial networks.

The role of mycorrhizal associations in controlling forest soil carbon storage remains under debate. This uncertainty is potentially due to an incomplete understanding of their influence on the free-living soil microbiome and its functions. In this study, rhizosphere and non-rhizosphere soils were collected from eight arbuscular mycorrhizal (AM) and seven ectomycorrhizal (ECM) tree species in a temperate forest.

First report of causing winged leaf dieback disease on in Yunnan Province, China.

Rhus chinensis, a deciduous tree of the genus Rhus (family Anacardiaceae), is widely cultivated in China for its medicinal, edible, and ornamental value (Zhang et al., 2022). In April 2022, symptoms of winged leaf dieback disease were observed at Southwest Forestry University in Kunming, Yunnan Province, China (E102°45'42.