Cellulose- and Saccharide-Based Orally Dispersible Thin Films Transform the Solid States and Dissolution Characteristics of Poorly Soluble Curcumin.

This study aimed at developing and optimizing the orally dispersible thin film (ODTF) containing a plant-derived drug-curcumin (CUR). CUR belongs to a biopharmaceutical classification system (BCS) class IV compound that requires improving its water solubility and tissue permeability preceding formulation. An ODTF was applied to produce a solid dispersion matrix for CUR to resolve such solubility and permeability problems.

Encysted hydrocele of spermatic cord: A rare case report with review of literature.

Introduction: Funiculus hydrocele is an uncommon anomaly characterized by obstruction in the closure of the processus vaginalis. The two variations of funiculus hydrocele are the encysted variety that is not related to the peritoneal cavity and the funicular variety that is associated with the peritoneal cavity. We report the clinical investigation and management of a very rare case of encysted spermatic cord hydrocele in a 2-year-old boy.

Delayed progressive intracranial bleeding in pediatric acute epidural hemorrhage treated expectantly.

Introduction And Importance: Progressive epidural hematoma (PEDH) after traumatic brain injury is usually found in the first 24 h after accident. However, EDH enlargement on day six after admission is rarely observed.

Presentation Of Case: We present the case of a 14-year-old boy who presented to the emergency room after a car accident with only a headache without any neurological deficit.

Resistance of mold spores to the light-emitting diode (LED), LED-assisted thermal and thermal processing in strawberry and apple juices.

The use of light-emitting diode (LED) technology for the non-thermal processing of foods is a major topic of interest among various research groups. This study is aimed at inactivating the ascospores present in strawberry and apple juices using a combination of a visible LED (vis-LED, 430-630 nm, 216-420 J/cm) and 90 °C thermal treatment, as well as to compare the findings with the inactivation done using thermal-processes alone. The results showed that violet-blue LEDs within the range of 430 and 460 nm with an energy between 300 and 420 J/cm were better for the inactivation of ascospores than the green and red LEDs which were within the 550-630 nm region with an energy range from 216 to 264 J/cm.

Enzyme Activity of Cellulolytic Bacteria from Biological Education and Research Forest Floor Andalas University.

<b>Background and Objective:</b> The composition of the waste consists mostly of plant biomass. Cellulose is the largest component of plant biomass and cellulolytic bacteria are needed to degrade it. This study aimed to determine enzyme activity possessed by bacterial isolates from Biological Education and Research Forest floor Andalas University.

Bacteria and Mold Spore Heat Resistance in Guava Juice and Its Control by pH and Sodium Benzoate.

Heat-resistant bacteria and molds can survive the pasteurization conditions used in high-acid fruit juices. The objective of this study was to evaluate the log reductions and thermal inactivation kinetics of spores of bacteria and ascospores of and molds under influence of pH and sodium benzoate preservative. The spores were suspended in guava juice, processed at 90-100°C for and at 80-90°C for and , and decimal reduction () values were estimated from the log survivor curves.

Effect of temperature and soluble solid on and spore inactivation and quality degradation of pineapple juice.

and spores can survive processing temperatures used in the thermal processes of high-acid foods. Therefore, this study investigated the thermal inactivation of and spores in pineapple juice at different temperatures (85-100°C) and soluble solids (SS, 11-30°Brix). The quality of juices and microbial loads after the thermal treatments during storage at 4 °C for 35 days was then checked.

The effects of glutathione on malondialdehyde expression and seminiferous tubule damage in experimental testicular torsion-detorsion in Wistar rats.

Introduction: Testicular damage caused by ischemia reperfusion injury can be determined by malondialdehyde (MDA) expression and grading of the histopathological damage to seminiferous tubules. The aim of this study was to investigate the effect of Tationil Glutathione administration on testicular damage following experimental torsion and detorsion.

Methods: Eighteen Wistar albino rats, 5.

Anti-babesial compounds from Curcuma xanthorrhiza.

Anti-babesial ingredients, (12R)- and (12S)-12,13-dihydro-12,13-dihydroxyxanthorrhizols, were isolated from Curcuma xanthorrhiza. The structures were established by the extensive NMR techniques. The assignments of (1)H NMR data of (12R)-12,13-dihydro-12,13-dihydroxyxanthorrhizol was revised, and (12S)-12,13-dihydro-12,13-dihydroxyxanthorrhizol was isolated as a pure form for the first time.

Evaluation of the inhibitory activities of the extracts of Indonesian traditional medicinal plants against Plasmodium falciparum and Babesia gibsoni.

Twenty-four kinds of water extracts derived from 22 plants that are traditionally used for the treatment of malaria on Java Island, Indonesia, were screened for their antibabesial and antimalarial activities. Among the extracts, 8 extracts displayed strong antimalarial activity, with an inhibition range from 89.6 to 100%, and 15 showed strong antibabesial activity, with an inhibition range from 84.

Anti-babesial compounds from Curcuma zedoaria.

Anti-babesial activity was confirmed in an extract of the bark of Curcuma zedoaria. The active ingredients were isolated, and their chemical structures were determined to be zedoalactones A, B, and C based on spectral data. Zedoalactone C is a hitherto unreported compound.

Anti-babesial activity of some central kalimantan plant extracts and active oligostilbenoids from Shorea balangeran.

Bark extracts from a total of 22 species of Central Kalimantan plants were evaluated for their anti-babesial activity against Babesia gibsoni in vitro. Of these plant species, extracts of Calophyllum tetrapterum, Garcinia rigida, Lithocarpus sp., Sandoricum emarginatum, and Shorea balangeran showed more than 90% inhibition of the parasite growth at a test concentration of 1000 microg/mL.

Anti-babesial and anti-plasmodial compounds from Phyllanthus niruri.

Bioassay-guided fractionation of boiled aqueous extracts from the whole plant of Phyllanthus niruri led to the isolation of 1-O-galloyl-6-O-luteoyl-alpha-d-glucose (1), with IC(50) values of 4.7 microg/mL against Babesia gibsoni and 1.4 microg/mL against Plasmodium falciparum in vitro.

Antibabesial activity of protoberberine alkaloids and 20-hydroxyecdysone from Arcangelisia flava against Babesia gibsoni in culture.

Bioassay-guided fractionation of the boiled extract from the stems of Arcangelisia flava led to the isolation of palmatine (1), berberine (2), jatrorrhizine (3), dihydroberberine (4) and 20-hydroxyecdysone (5). The chemical structures of these compounds were elucidated on the basis of their chemical and spectral evidence. The isolated compounds were evaluated for their growth inhibiting effects on Babesia gibsoni in culture for a week.

Effects of Central Kalimantan plant extracts on intraerythrocytic Babesia gibsoni in culture.

The inhibitory effects of 45 plant extracts selected from Central Kalimantan, Indonesia on Babesia gibsoni in vitro and their acute toxicity to mice were evaluated. Of these plant extracts studied, Arcangelisia flava, Curcuma zedoaria, Garcinia benthamiana, Lansium domesticum and Peronema canescens were found to have appreciable antibabesial activity with IC50 values from 5.3 to 49.