Correction: Correlation between cognition and plasma noradrenaline level in Alzheimer's disease: a potential new blood marker of disease evolution.

A Correction to this paper has been published: https://doi.org/10.1038/s41398-020-01102-y.

Correlation between cognition and plasma noradrenaline level in Alzheimer's disease: a potential new blood marker of disease evolution.

Recent evidence showing degeneration of the noradrenergic system in the locus coeruleus (LC) in Alzheimer's disease (AD) has motivated great interest in noradrenaline (NA) as a potential brain hallmark of the disease. Despite the current exploration of blood markers for AD, the deregulation of the plasma NA concentration ([NA]) in AD is currently not well understood. This retrospective study includes a cohort of 71 patients (32 AD patients, 22 with other dementia and 17 without dementia) who were given consultations for memory complaints in the Cognitive Neurology Center of Lariboisière (Paris) between 2009 and 2014.

Cation exchange frontal chromatography for the removal of monoclonal antibody aggregates.

A low ligand density cation exchange (CEX) chromatography resin, Eshmuno CP-FT resin, was investigated for the removal of aggregates from monoclonal antibody (mAb) feeds using a continuous loading process. Removing mAb aggregates with a CEX resin using continuous loading is advantageous relative to a bind/elute loading process, because the resin can use nearly its full capacity to bind the aggregates enabling much higher loadings. The removal of mAb aggregates with Eshmuno CP-FT resin using a continuous loading process was found to be consistent with a frontal chromatography mechanism where the mAb monomer initially binds to the column and is subsequently displaced by dimers and higher molecular weight aggregates.

Continuous In-Line Virus Inactivation for Next Generation Bioprocessing.

Viral inactivation plays a critical role in assuring the safety of monoclonal antibody (mAb) therapeutics. Traditional viral inactivation involves large holding tanks in which product is maintained at a target low pH for a defined hold time, typically 30-60 min. The drive toward continuous processing and improved facility utilization has provided motivation for development of a continuous viral inactivation process.

Frequency of nonsystem delays in ST-elevation myocardial infarction patients undergoing primary percutaneous coronary intervention and implications for door-to-balloon time reporting (from the American Heart Association Mission: Lifeline program).

The percentage of patients with primary percutaneous coronary intervention (PCI) with door-to-balloon (D2B) times ≤90 minutes is used as a hospital performance measure for public reporting. Patients can be excluded from reporting for nonsystem-related delays. How exclusions impact D2B time reporting at the hospital level is unknown.

Newborn car bed testing in a community hospital: implementing the American Academy of Pediatrics recommendations.

Objective: This study was designed to describe our experience in implementing the American Academy of Pediatrics (AAP) recommendation to test infants in a car bed if they fail a car seat challenge test.

Study Design: Car seat challenge testing was performed for 90 minutes or the anticipated duration of the trip home, whichever was longer. Based on the pulse oximetry saturation values (90-92% or < 90%) two categories of test failure were used.

The direct field boundary impedance of two-dimensional periodic structures with application to high frequency vibration prediction.

Large sections of many types of engineering construction can be considered to constitute a two-dimensional periodic structure, with examples ranging from an orthogonally stiffened shell to a honeycomb sandwich panel. In this paper, a method is presented for computing the boundary (or edge) impedance of a semi-infinite two-dimensional periodic structure, a quantity which is referred to as the direct field boundary impedance matrix. This terminology arises from the fact that none of the waves generated at the boundary (the direct field) are reflected back to the boundary in a semi-infinite system.

Response variance prediction for uncertain vibro-acoustic systems using a hybrid deterministic-statistical method.

Imperfections during the manufacturing process can cause significant variations in the noise and vibration levels exhibited by nominally identical structures. Any response calculations employed during the design process should ideally take account of these uncertainties and predict the expected range in performance. Recently a hybrid method has been developed to predict the ensemble average response of a built-up system by combining a deterministic model of parts of the system with a statistical model of other components [Shorter, P.

Numerical and experimental validation of a hybrid finite element-statistical energy analysis method.

The finite element (FE) and statistical energy analysis (SEA) methods have, respectively, high and low frequency limitations and there is therefore a broad class of "mid-frequency" vibro-acoustic problems that are not suited to either FE or SEA. A hybrid method combining FE and SEA was recently presented for predicting the steady-state response of vibro-acoustic systems with uncertain properties. The subsystems with long wavelength behavior are modeled deterministically with FE, while the subsystems with short wavelength behavior are modeled statistically with SEA.

Cored anion-exchange chromatography media for antibody flow-through purification.

Agarose-based anion-exchangers (e.g. quaternary amine, Q) have been widely used in monoclonal antibody flow-through purification to remove trace levels of impurities.

Response variance prediction in the statistical energy analysis of built-up systems.

In the statistical energy analysis (SEA) of high frequency noise and vibration, a complex engineering structure is represented as an assembly of subsystems. The response of the system to external excitation is expressed in terms of the vibrational energy of each subsystem, and these energies are found by employing the principle of power balance. Strictly the computed energy is an average taken over an ensemble of random structures, and for many years there has been interest in extending the SEA prediction to the variance of the energy.

[Ring chromosome 10: 46,XX,r(10)(p15q26)].

A teenage girl with growth and mental retardation, urinary tract and eye abnormalities was found to have an r(10)(p15q26) in blood cells. Quantitative evaluation of seven red cell enzymes including three (HK1, TGOS, PGAMA) known to be on chromosome 10, gave normal values.

[Priapism in a 13 year old boy. Caverno-spongiosal anastomosis with a successful result (author's transl)].

Idiopathic priapism is rare and even more so when it affects a pre-pubertal child. The authors study this curious disorders on the basis of one case and show the value of caverno-spongiosal anastomosis, even when carried out late.