A simplified regimen for treatment of skin and soft tissue infections.

Clinical responses were nearly identical in a controlled double-blind study in which 131 patients with skin or soft tissue infections caused by Staphylococcus aureus received a cephalosporin antibiotic (cephradine) given twice (70 patients) or four times daily (61 patients). Satisfactory responses were obtained in approximately 95 percent of patients treated with either regimen. Eradication of S.

Intravenous use of cephradine and cefazolin against serious infections.

The relative efficacy and safety of cephradine and cefazolin were compared in 180 patients with a variety of serious infections caused by susceptible organisms. The patients were randomly assigned to one of two groups of 90 patients each. Most patients received 2 to 4 g per day, administered by intravenous injection in four equally divided doses, for a minimum of 4 days.

"Discontinuous" antibiotic therapy for urinary tract infections.

Although it is a common belief that most antibiotics require 4 doses daily, on theoretical grounds such frequent administration may not be necessary (at least for bactericidal antibiotics) and can compromise patient compliance. In 548 patients with urinary tract infections studied under double-blind conditions, 1 g of cephradine orally twice daily provided results equivalent to those obtained with 500 mg of cephradine given 4 times a day. A total of 242 (89%) of 272 patients in the b.