T Cell-Mediated Targeted Delivery of Anti-PD-L1 Nanobody Overcomes Poor Antibody Penetration and Improves PD-L1 Blocking at the Tumor Site.

Monoclonal antibodies (mAbs) blocking immune checkpoints such as programmed death ligand 1 (PD-L1) have yielded strong clinical benefits in many cancer types. Still, the current limitations are the lack of clinical response in a majority of patients and the development of immune-related adverse events in some. As an alternative to PD-L1-specific antibody injection, we have developed an approach based on the engineering of tumor-targeting T cells to deliver intratumorally an anti-PD-L1 nanobody.

[Family caregivers and hereditary muscular disorders: association between burden, quality of life and mental health].

Objective: The analysis of caregiver difficulties seems important to define the life of the patient. The aim of the study was to evaluate the burden of perceived care, health-related quality of life, and mental health of family caregivers who care for patients with hereditary neuromuscular disease.

Materials And Method: Fifty-nine family caregivers were investigated in the course of multidisciplinary consultations in Reims, France, between April 2002 and February 2005.

[Anterior subtalar dislocation associated with a fracture of the calcaneus: a case report and review of the literature].

A new case of uncommon anterior subtalar dislocation associated with a fracture of the calcaneus is reported. Mechanism of production is described with a review of literature. The criteria of radiologic diagnosis are mentioned.

[Sub-trochanteric fractures. A comparative study between gamma nail and angular osteosynthesis with lateral cortical support].

Purpose Of The Study: Treatment and outcome of sub-trochanteric fractures are at the origin of many problems. The aim of this study was to evaluate the superiority of the "Gamma Nail".

Material And Methods: Two homogenous groups of patients were studied.

Influence of timing on the analgesic effect of intravenous ketorolac after orthopedic surgery.

This study evaluated the pre-emptive analgesic effect of intravenous (i.v.) ketorolac (KET) for total hip replacement (THR).

[Locking of the metacarpophalangeal joint of articular origin. Review of the literature and case report].

We report a case and review concerning literature of intrinsic locking of the metacarpophalangeal joint. These lockings are usually due commonly to degenerative arthritis of the joint, rarely to an abnormal shape of the head of metacarpal or intraarticular loose bodies. They should be differentiated from the extension lag of proximal interphalangeal joint usually encountered in "trigger finger" due to stenosing tenosynovitis.

[Strictly epidermotropic "Ketron Goodman"-type lymphoma. Immunohistochemical and ultrastructural analysis of a case].

We report a case of T cell lymphoma which was exclusively located within the epidermis. The T cells of this lymphoma were all of suppressor-cytotoxic phenotype. They did not express the CD7 antigen and a molecular biology study showed T cell type genotypic rearrangements.

[Partial or total enucleation of the talus. Value of conservative treatment. Apropos of 8 cases].

Eight cases of talus enucleations are reported. The patients ranged in age from 18 to 62 years. The follow-up period in this study extended from one year to 12 years.

[Recent fractures of the humeral diaphysis in adults. Comparison of orthopedic and surgical treatment. Apropos of 252 cases].

Two hundred and fifty two cases of fracture of the humeral shaft have been treated by the authors, half conservatively by mobilisation against the chest wall and half surgically. The main surgical procedures were plating, nailing without reaming, fascicular intramedullary pinning, or external fixation. Conservative treatment gave satisfactory results without iatrogenic complications.

[Subtalar dislocations with medial or lateral displacement (author's transl)].

The authors have observed 20 cases of subtalar dislocation, 16 with medial displacement and 4 with lateral displacement. The treatment given and the results are described. An experimental study has also been made which confirms that in medial dislocations the talo-navicular joint dislocates first whilst in lateral dislocations the talo-navicular joint dislocates last.

[The surgical treatment of fractures of the upper end of the humerus by blind pinning (author's transl)].

During a period of five years, the authors have treated 250 fractures of the upper end of the humerus. Fifty-one were treated by blind pinning. Six to eight Kirschner wires are passed up to the head of the humerus under X-ray control through a hole made on the posterior aspect of the lower end of the humerus just above the olecranon fossa.

[Congenital nodular fibromatosis: report of six personal cases (author's transl)].

Six personal cases of nodular congenital fibromatosis are reported: one fibromatosis colli, two fibromas of the fingers one multiple fibromas of the toes and sole associated with osteoporosis and underlying bone lacunes, one recurrent plantar fibromatosis, one disseminated fibromatosis with multiple bone lesions. Such varieties of fibromatosis are very uncommon. Few are isolated such as fibromatosis colli or the fibroma of the fingers.