Effects of acute and chronic ranitidine administration on renal function and parathyroid activity in chronic renal failure.

In 11 patients with advanced renal failure, chronic treatment with ranitidine decreased plasma immunoreactive parathormone (PTH) without affecting phosphate reabsorption or urinary excretion of cyclic AMP. No significant changes in glomerular filtration rate and in urinary excretion of electrolytes were evident.