Clinical indications for radical resection of odontogenic keratocyst: A systematic review.

The aim of this study was to identify clinico pathological indications for radical resection of odontogenic keratocysts (OKCs) in the literature and formulate clinical guidelines for the management of OKCs based on these findings. A systematic review of the literature was undertaken in September 2021 in PubMed/Medline, Scopus, Web of Science, Google Scholar, and Cochrane databases. The following MeSH Keywords terms were used in the search strategies: (odontogenic keratocyst) OR (keratocystic odontogenic tumor) OR (primordial cyst) AND (treatment) OR (Radical resection) OR (Resection of OKC) OR (Treatment methods).

Berberine suppresses the migration and invasion of colon cancer cells by inhibition of lipogenesis through modulation of promyelocytic leukemia zinc finger-mediated sterol-regulatory element binding proteins cleavage-activating protein ubiquitination.

Objectives: This study was aimed to explore whether and how berberine suppresses colon cancer cell metastasis via lipid modulation.

Methods: Lipid accumulation was measured by an oil red O staining kit. The expression of proteins and message RNA was detected by Western blot and quantitative real-time PCR.

Effect of peri-implant bone resorption on mechanical stress in the implant body: In vivo measured load-based finite element analysis.

Background: Research on resolving implant fracture is still gaining attention as it can be a serious treatment failure outcome. The implant fracture is likely to occur due to increased stress in implant body associated with peri-implant bone resorption.

Objective: This study aimed to investigate the relationship between degree of peri-implant bone resorption and stress distribution in implant body by using finite element analysis (FEA).

Management of mandibular odontogenic keratocyst through radical resection: Report of 35 cases.

The present study reported the clinical outcomes of 35 patients with mandibular odontogenic keratocysts (OKCs) following treatment by radical resection and immediate defect reconstruction. Amongst 565 patients with OKCs that were treated between April 2003 and May 2015, 35 patients underwent segmental or marginal mandibulectomy. The use of radical resection was based on clinical and/or radiographic evidence of size, cortical perforation and subsequent soft tissue involvement, and on the history of previous recurrence of the same lesion.

Expression and associations of TRAF1, BMI-1, ALDH1, and Lin28B in oral squamous cell carcinoma.

Tumor necrosis factor receptor-associated factor 1, an adaptor protein of tumor necrosis factor 2, is involved in classical nuclear factor (NF)-κB activation and lymphocyte recruitment. However, less is known about the expression and association of tumor necrosis factor receptor-associated factor 1 with cancer stem cell markers in oral squamous cell carcinoma. This study aimed to investigate the expression of tumor necrosis factor receptor-associated factor 1 and stem cell characteristic markers (lin28 homolog B, B cell-specific Moloney murine leukemia virus integration site 1, and aldehyde dehydrogenase 1) in oral squamous cell carcinoma and analyze their relations.

Levels of anti-BP180 NC16A IgE do not correlate with severity of disease in the early stages of bullous pemphigoid.

Bullous pemphigoid (BP), a common autoimmune skin disease, is associated with IgG autoantibodies against the hemidesmosomal proteins, BP180 and BP230. In addition to IgG, IgE has been shown to play a role in the disease. However, the association between disease activity and IgE specific to the NC16A domain of BP180 in blister fluid remains unclear.

UNC-51-like kinase 1 expression in radical nephrectomy specimens as a predicting factor of progression-free survival in patients with metastatic renal cell carcinoma treated with mammalian target of rapamycin inhibitors.

Background: To analyze basal expression levels of multiple components in the autophagy pathway in radical nephrectomy specimens from patients with metastatic renal cell carcinoma (mRCC) treated with mammalian target of rapamycin (mTOR) inhibitors, to identify factors predicting susceptibility to these agents.

Methods: This study included 48 consecutive patients undergoing radical nephrectomy, who were diagnosed with mRCC and subsequently treated with either everolimus or temsirolimus. Expression levels of 5 major molecular markers involved in the signaling pathway associated with autophagy, including autophagy-related protein (Atg)5, Atg9, Beclin1, microtubule-associated protein light chain 3, and UNC-51-like kinase 1 (ULK1), were measured by immunohistochemical staining of primary renal cell carcinoma specimens.

Luciferase expression is driven by the promoter of fibroblast activation protein-α in murine pulmonary fibrosis.

Objectives: We used optical imaging of live animals and transgenic technology to develop a pulmonary fibrosis model in mice that can non-invasively and in real-time trace the pulmonary fibrosis process.

Results: Fibroblast activation protein-α (FAPα) is selectively expressed in fibrotic foci of human pulmonary fibrosis. It is not expressed in normal tissue.

Multiple layers lens capsule true exfoliation in patient with primary angle closure glaucoma.

Introduction: True exfoliation of lens capsule is a relatively rare disorder that has a thin, fluttering membrane in the anterior chamber, mainly located in the pupil area, which is believed to have split from the anterior lens capsule.

Case Report: The authors present here a patient with true exfoliation and primary angle closure glaucoma in both eyes, the ultrastructure of one eye revealed that the delaminated membrane was composed of more than two layers in itself.

Conclusion: Lens capsule true exfoliation could happen in patient with primary angle closure glaucoma, with more than two layers in itself.

Impact of smoking and smoking cessation on arterial stiffness in healthy participants.

Smoking is associated with increased arterial stiffness. However, the impact of smoking cessation on arterial stiffness remains unknown. We investigated the effect of smoking cessation on arterial stiffness.

Removal of a long PVC pipe strangulated in the penis by hot-melt method.

Introduction: Penile incarceration for erotic or autoerotic purposes has been reported in a wide range of age groups, and often presents a significant challenge to urologic surgeons. No ready method has been reported for removing a polyvinylchloride (PVC) pipe entrapped on the penis.

Aim: To present our experience in using hot-melt method to remove a constricted PVC pipe on the penis.

Adrenal ganglioneuromas: a 10-year experience in a Chinese population.

Background: Adrenal ganglioneuroma (GN) is extremely rare. The present study is to describe the largest series of this adrenal tumor treated in a single medical center to our knowledge.

Methods: Clinical details, radiologic, laboratory, and pathologic findings as well as follow-up data were analyzed retrospectively in 17 patients with incidentally discovered adrenal GN who received operative resection at a tertiary referral hospital in eastern China between June 1999 and June 2009.

AmpC promoter and attenuator mutations affect function of three Escherichia coli strains.

To investigate the correlation between mutations in promoter, attenuator, and the AmpC enzyme overproduction in Escherichia coli. ampC Promoters from 4 Escherichia coli clinical isolates were cloned upstream to the chloramphenicol acetyltransferase (CAT) gene in pCAT3 reporter plasmid. Promoter strengths were measured by chloramphenicol MIC and gene sequencing was done on the cloned ampC promoter and attenuator.

Gene expression profiles of nasal polyps associated with allergic rhinitis.

Background: Nasal polyp (NP) is a common and frequently occurring disease in otorhinolaryngology head and neck surgery, the pathogenesis of which remains unclear. Differentially expressed genes of mucosal tissues from NP, allergic rhinitis (AR), and normal nasal cavities were screened out by oligonucleotide chip technique and verified by real-time polymerase chain reaction (PCR) and immunohistochemical staining.

Objective: To study gene expression profiles of nasal polyps associated with AR and explore the pathogenic mechanisms of NP at the level of molecular biology.

Analysis on the chaotic characteristics of postganglionic inferior cardiac sympathetic nerve activity.

Taking cats as experiment animal model, the chaotic characteristics of postganglionic inferior cardiac sympathetic nerve activity (PICSNA) is analyzed with Cao method, correlation dimension analysis and largest Lyapunov exponent analysis. The analysis results show that the deterministic chaos lies in the peak-peak interval time series of PICSNA. Our work maybe can help explain why HRV is chaotic.

The antioxidative and immunostimulating properties of D-glucosamine.

The objective of the present study was to investigate the antioxidant activity and immunostimulating property of glucosamine (GlcN) using various in vitro and in vivo tests. Results showed that GlcN possessed excellent antioxidant activities as manifested by strong chelating effect on ferrous ions and protection of macromolecules such as protein, lipid, and deoxyribose from oxidative damage induced by hydroxyl radicals. The immunostimulating effects of GlcN were further evaluated through various immunological tests.

Protective effects of chitosan oligosaccharide and its derivatives against carbon tetrachloride-induced liver damage in mice.

The protective effects of chitosan oligosaccharide (COS), d-glucosamine (GlcNH(2)) and N-acetyl-d-glucosamine (GlcNAc) on carbon tetrachloride (CCl(4))-induced hepatotoxicity and the possible mechanisms that involved were investigated in male ICR mice. CCl(4) (20mg/kg body weight, i.p.

Chromosomal aberrations induced by (12)C6+ ions and 60Co gamma-rays in mouse immature oocytes.

The ovaries of Kun-Ming strain mice (3 weeks) were irradiated with different doses of (12)C6+ ion or (60)Co gamma-ray. Chromosomal aberrations were analyzed in metaphase II oocytes at 7 weeks after irradiation. The relative biological effectiveness (RBE) of (12)C6+ ion was calculated with respect to 60Co gamma-ray for the induction of chromosomal aberrations.

Cloning and characterization of a novel splicing isoform of the iron-superoxide dismutase gene in rice (Oryza sativa L.).

Superoxide dismutases (SODs) are ubiquitous metalloenzymes in aerobic organisms that play a crucial role in protecting organisms against ROS. Here, we report the molecular cloning and functional characterization of a novel alternatively spliced variant of the iron-superoxide dismutase gene, OsFe-SODb, from a rice panicle cDNA library. The alternative splicing event occurred in the fourth exon of the OsFe-SOD gene, and led to the translation of two isoforms of different sizes.

Effectiveness of self-referral for male patients with urethral discharge attending a sexually transmitted disease clinic in China.

Background: Although partner notification (PN) has long been considered as an important component in sexually transmitted disease (STD) control programs and has been implemented in both developed and developing world, little information is known about the acceptability and efficacy of the strategy in China.

Goal: The goal of this study was to assess the acceptability and outcome of self-referral for male patients with urethral discharge and to identify the characteristics associated with successful outcome based on a specialized STD clinic.

Methods: From November 2001 to November 2002, 730 patients with confirmed urethral discharge were selected and asked by STD clinicians to bring their sexual contacts to treatment in a specialized STD clinic.

Role of leprosy villages and leprosaria in Shandong Province, People's Republic of China: past, present and future.

In the late phase of the leprosy control programme in Shandong Province, People's Republic of China, there are a few old and disabled ex-patients living in 54 leprosy villages/leprosaria. The small, and declining number of patients makes the running of these leprosy villages/leprosaria uneconomic. In this paper, we review the history and the role of leprosy villages/leprosaria in the care of leprosy patients and the control programme in Shandong province.

Assessment of disability, social and economic situations of people affected by leprosy in Shandong Province, People's Republic of China.

With the decline in prevalence of leprosy, social and economic rehabilitation (SER) has become a major priority in leprosy control programme in Shandong Province. In the preparative phase of an SER programme, a province-wide survey was conducted with a semi-structured questionnaire in order to provide policy makers and programme managers with some basic information on the disability, and social and economic situation of the people affected by leprosy. This paper presents the results of a study in the people affected by leprosy living in the communities.