Epicardial adipose tissue, myocardial remodelling and adverse outcomes in asymptomatic aortic stenosis: a post hoc analysis of a randomised controlled trial.

Background: Epicardial adipose tissue represents a metabolically active visceral fat depot that is in direct contact with the left ventricular myocardium. While it is associated with coronary artery disease, little is known regarding its role in aortic stenosis. We sought to investigate the association of epicardial adipose tissue with aortic stenosis severity and progression, myocardial remodelling and function, and mortality in asymptomatic patients with aortic stenosis.

[A case of adult temporal bone langerhans cell histiocytosis presenting as posterior canal dehiscence syndrome and literature review].

This report describes a case of adult temporal bone Langerhans cell histiocytosis（LCH） that presented as posterior canal dehiscence syndrome（PCDS）. The patient initially presented with vertigo, tinnitus, and hearing loss. Computed tomography（CT） revealed erosive changes in the mastoid and posterior semicircular canal.

Evolution of sarcopenia status and risk of incident cardiovascular disease.

Aims: Sarcopenia is an emerging risk factor for cardiovascular disease (CVD). However, previous studies did not take into consideration the cardiovascular impact of the changes in sarcopenia status. We investigated the relationship between changes in sarcopenia status and incident CVD.

Endophytic fungus Stagonosporopsis ajaci NEAU-BLH1 from Adonis amurensis enhances seed germination under low-temperature stress and increases grain yield in direct-seeded rice.

Rice direct-seeding technology is regarded as a promising alternative to traditional transplanting due to its labor- and water-saving benefits. However, poor seedling emergence and growth under low-temperature stress remain major obstacles to its widespread adoption in Heilongjiang Province, China. Here, we isolated an endophytic fungus Stagonosporopsis ajaci NEAU-BLH1 from the cold-resistant plant Adonis amurensis, which effectively enhanced rice seed germination and seedling growth under low-temperature stress.

Discovery of (+)-Methyl Nonactate as a Potential Fungicide against Gummy Stem Blight.

Gummy stem blight (GSB), which is caused by , threatens pumpkin yields and agriculture. Effective, safe antifungal agents are urgently needed. In this study, fermentation broth supernatant of sp.

Effects of colchicine adjuvant therapy on disease control, serum NALP3, sICAM-1, MMP-9 and MMP-13 in patients with coronary heart disease and acute gout attack.

Background: To investigate the impact of colchicine adjuvant therapy on disease control and serum levels of nucleotide-binding oligomerization domain-like receptor (NALP) 3, soluble intercellular adhesion molecule (sICAM)-1, matrix metalloproteinase (MMP)-9, and MMP13 in patients with coronary heart disease (CHD) complicated by acute gout attacks.

Methods: Ninety-two patients with CHD and acute gout attacks admitted to our hospital from October 2021 to January 2023 were randomly divided into an observation group and a control group, with 46 patients in each group. The control group received conventional treatment, while the observation group received colchicine adjuvant therapy on top of the control group's treatment for 7 days.

Sex-Specific Association of Myocardial Fibrosis With Mortality in Patients With Aortic Stenosis.

Importance: Myocardial fibrosis in aortic stenosis (AS) may exhibit sex differences. However, its prognostic significance in women with AS remains unclear.

Objective: To investigate sex differences in myocardial fibrosis assessed by cardiovascular magnetic resonance (CMR) and evaluate its prognostic value in women and men with AS.

Atractylenolide I ameliorates post-infectious irritable bowel syndrome by inhibiting the polymerase I and transcript release factor and c-Jun N-terminal kinase/inducible nitric oxide synthase pathway.

Objective: To explore the therapeutic effect and target of atractylenolide I (AT-I) on post-infectious irritable bowel syndrome (PI-IBS) rats.

Methods: Therefore, the preliminarily mechanism of AT-I in anti-PI-IBS were first predicted by network pharmacology and molecular docking, then the possible signaling pathways were systematically analyzed. Finally, the potential therapeutic targets and possible signaling pathways of AT-I on PI-IBS in Sprague-Dawley (SD) rat model were verified by experiments.

Case Report of an Obstructive Endotracheal Mass from a Blood Clot: An Airway Nightmare.

Background: Central airway obstruction from a mass is a rare but deadly manifestation of advanced primary lung cancer that can cause considerable challenges during endotracheal intubation, including airway debris or bleeding, ventilation difficulties, and prolonged postintubation hypoxia.

Case Report: This case report describes a patient presenting with the chief symptom of massive hemoptysis who was difficult to ventilate and oxygenate after an easy intubation. On bedside bronchoscopy, an obstructing mass was found at the carina that was later determined to be caused by a blood clot.

Emergency Admission Plasma D-Dimer and Prothrombin Activity: Novel Predictors for Clinical Outcomes After Thrombectomy in Acute Ischemic Stroke With Large Artery Occlusion.

Background: The coagulation system is intrinsically linked to pathological mechanisms and progression of ischemic stroke. However, the role of preoperative coagulation function in determining the functional outcomes of acute ischemic stroke patients following large artery occlusion (AIS-LVO) has not been extensively evaluated in peer-reviewed literature.

Methods: We utilized logistic regression analyses, complemented by the construction of receiver operating characteristic (ROC) curves, to identify significant predictive factors for poor prognosis following endovascular thrombectomy (EVT).

Clinical and Laboratory Risk Factors of Early Poor Outcome in Patients With Childhood-Onset Lupus Nephritis-A Single-Center Retrospective Study.

Objective: Childhood-onset lupus nephritis (LN) tends to be more severe than in adults. A significant correlation between remission at 3 months of induction therapy and remission after 3 years was found in adults. While few studies on the risk factors of poor early prognosis in children with LN were made.

An updated systematic review, meta-analysis and trial sequential analysis of the efficacy and safety of en bloc transurethral resection vs. conventional transurethral resection for non-muscle-invasive bladder tumor.

Objective: En bloc transurethral resection of bladder tumor (ERBT) for non-muscular invasive bladder tumor (NMIBC) has been used in clinical practice, but its efficacy and safety have not been conclusional. We aimed to evaluate the efficacy and safety of ERBT and conventional transurethral resection of bladder tumor (cTURBT) for NMIBC.

Methods: Randomized controlled trials (RCTs) comparing ERBT and cTURBT in the treatment of NMIBC were searched in Pubmed, Embase, Clinicaltrials.

From bedrock to life activity and atmospheric deposition: Drivers of soil element coupling across horizons.

Unraveling the intricate coupling of multiple elements and their underlying drivers in natural soils is crucial for comprehending ecosystem functions, yet this knowledge has remained elusive. Using a comprehensive dataset of 900 soil samples collected from 116 sites across 26 mountains, this study dissected the coupling relationship of 23 elements within three soil development horizons, spanning five climate zones in China. Our findings revealed a robust continental-scale coupling of soil elements, influenced by plants and environmental factors including spatial distance, climate, soil properties, and atmospheric nitrogen deposition, accounting for 36% of the observed variance in element coupling.

Platelet-rich fibrin attenuates inflammation and fibrosis in vulvar lichen sclerosus via the TGF-β/SMAD3 pathway.

Vulvar lichen sclerosus (VLS) is a chronic, inflammatory, and progressive skin disease mainly involved in the anogenital area. Platelet-rich fibrin (PRF) is a fibrin adhesive-concentrated platelet-rich plasma (PRP) used for tissue repair and angiogenesis. In this study, we explored the effects of PRF on VLS patients, further to utilize the established VLS animal model, to confirm the therapeutic effect of PRF and regulation on the TGF-β/SMAD3 pathway.

Enhanced clinical photoacoustic vascular imaging through a skin localization network and adaptive weighting.

Photoacoustic tomography (PAT) is an emerging imaging modality with widespread applications in both preclinical and clinical studies. Despite its promising capabilities to provide high-resolution images, the visualization of vessels might be hampered by skin signals and attenuation in tissues. In this study, we have introduced a framework to retrieve deep vessels.

Improved snow geese algorithm for engineering applications and clustering optimization.

The Snow Goose Algorithm (SGA) is a new meta-heuristic algorithm proposed in 2024, which has been proved to have good optimization effect, but there are still problems that are easy to fall into local optimal and premature convergence. In order to further improve the optimization performance of the algorithm, this paper proposes an improved Snow Goose algorithm (ISGA) based on three strategies according to the real migration habits of snow geese: (1) Lead goose rotation mechanism. (2) Honk-guiding mechanism.

Mixed-Matrix Membrane-Based Piezoelectric CO Sensor with Self-Humidity Compensation.

Monitoring the CO concentration is crucial for assessing respiratory illnesses in humans and safeguarding the environment. The ongoing difficulty lies in achieving highly sensitive detection while also eliminating the interference caused by humidity. There is an unmet need for portable sensors with both high sensitivity and good moisture resistance to monitor CO in real time.

Quantitative Comparison of Glucagon-Like Peptide-1 Receptor Agonists on Weight Loss in Adults: A Systematic Review and Model-Based Meta-Analysis.

The objective of this study is to quantitatively compare the weight loss effects of glucagon-like peptide-1 receptor agonists (GLP-1RAs) in adult patients with no diabetes and type 2 diabetes (T2D). PubMed, Cochrane Central Register of Controlled Trials (CENTRAL), and Embase have been used as data sources from database inception to January 6, 2024. A total of 137 trials, encompassing 310 treatment arms, 17 GLP-1RAs, and 56,683 patients, were included in the analysis.

Cell-free epigenomes enhanced fragmentomics-based model for early detection of lung cancer.

Background: Lung cancer is a leading cause of cancer mortality, highlighting the need for innovative non-invasive early detection methods. Although cell-free DNA (cfDNA) analysis shows promise, its sensitivity in early-stage lung cancer patients remains a challenge. This study aimed to integrate insights from epigenetic modifications and fragmentomic features of cfDNA using machine learning to develop a more accurate lung cancer detection model.

Recent Developments in 14-3-3 Stabilizers for Regulating Protein-Protein Interactions: An Update.

14-3-3 proteins play a crucial role in the regulation of protein-protein interactions, impacting various cellular processes and disease mechanisms. Recent advancements have led to the development of stabilizers that enhance the binding of 14-3-3 proteins to clients, presenting promising therapeutic potentials. This perspective provides an updated overview of the latest developments in the field of 14-3-3 stabilizers, with a focus on their design, synthesis, and biological evaluation.

Nanomedicine-enabled concurrent regulations of ROS generation and copper metabolism for sonodynamic-amplified tumor therapy.

Sonodynamic therapy (SDT) shows substantial potentials in cancer treatment thanks to the deep tissue penetration of ultrasound. However, its clinical translation suffers from the potential damages to healthy tissues and the resistance of tumors, particularly from cancer stem-like cells (CSCs), to the ultrasound. To address these challenges, we designed a novel glutathione (GSH)-activated nanomedicine to simultaneously enhance the safety and efficacy of SDT by in situ regulating the generation of reactive oxygen species (ROS) and copper metabolism.

Structural and kinetic characterization of an acetoacetyl-Coenzyme A: acetate Coenzyme A transferase from the extreme thermophile Thermosipho melanesiensis.

Family 1 Coenzyme A transferases (CtfAB) from the extremely thermophilic bacterium, Thermosipho melanesiensis, has been used for in vivo acetone production up to 70°C. This enzyme has tentatively been identified as the rate-limiting step, due to its relatively low-binding affinity for acetate. However, existing kinetic and mechanistic studies on this enzyme are insufficient to evaluate this hypothesis.

Transferring Mouse Emx1 and Emx2 Lentiviruses into the Chicken Embryonic Brain and Their Implication to the Organization and Evolution of the Amniote Pallium.

Introduction: Homeobox genes are highly conserved and play critical roles in brain development. Recently, we have found that mammals have an additional fragment of approximately 20 amino acids in Emx1 and a poly-(AL)6-7 in Emx2, compared to other amniotes. It has been shown that Emx1 and Emx2 have synergistic actions in the brain development.