The association between screen exposure and autism spectrum disorder in children: meta-analysis.

Introduction: The goal is to provide light on the contentious relationship between screen exposure and childhood autism spectrum disorder (ASD). By conducting two meta-analyses that showed a potential association, including screen exposure effect by ASD and ASD risk by screen exposure, we aimed to clarify the potential causality between screen exposure and childhood ASD.

Content: The literature published up to December 2023 were systematically collected, and the combined effect values of weighted mean difference (WMD) and 95 % confidence interval (CI) and odds ratio (OR) and 95 % CI were calculated using two meta-analyses using the STATA 12.

Comparative analysis of embodied carbon in modular and conventional construction methods in Hong Kong.

Addressing the rise in global temperatures and the associated increase in greenhouse gases, particularly carbon dioxide, is a critical challenge necessitating innovative approaches within the building sector, a significant contributor to worldwide carbon emissions. While previous studies have demonstrated the prefabrication's potential in reducing emissions, comprehensive assessments using actual project data for buildings constructed entirely with modular methods in Hong Kong are lacking. This study bridges this gap by evaluating the modular integrated construction (MiC) method through an embodied carbon assessment of the Kai Tak Community Isolation Facility.

Sinensetin interferes with Staphylococcus aureus infections by targeting staphylocoagulase and improves infection survival rates in mouse model of pneumonia.

Aims: Coagulase (Coa), a crucial virulence factor of Staphylococcus aureus (S. aureus), is considered a vital target for anti-virulence strategies. The research aimed to discover a natural compound capable of inhibiting S.

Baicalin protects against hepatocyte injury caused by aflatoxin B via the TP53-related ferroptosis Pathway.

Objective: Baicalin has antioxidative, antiviral, and anti-inflammatory properties. However, its ability to alleviate oxidative stress (OS) and DNA damage in liver cells exposed to aflatoxin B (AFB), a highly hepatotoxic compound, remains uncertain. In this study, the protective effects of baicalin on AFB-induced hepatocyte injury and the mechanisms underlying those effects were investigated.

Paediatric off-label use of drugs in Gansu, China: a multicentre cross-sectional study.

Objective: To examine the current prevalence and cost of paediatric off-label drug prescriptions in Gansu, China, and the potential influencing factors.

Design: The prevalence of off-label prescriptions in paediatrics was evaluated according to the National Medical Products Administration drug instructions in the China Pharmaceutical Reference (China Pharmaceutical Reference, MCDEX) database. The evidence of the prescription was determined by existing clinical practice guidelines and the Thomson Grade in the Micromedex 2021 compendium.

Closing the gap: Enhancing quality pediatric dermatologic care through project Extension for Community Healthcare Outcomes (ECHO).

This study focused on evaluating Extension for Community Healthcare Outcomes (ECHO) participating primary care clinician's (PCC's) diagnostic and treatment accuracy of pediatric dermatologic conditions. To evaluate this, pediatric cases presented to Dermatology ECHO by PCCs with questions regarding diagnosis, treatment regimen, or both were analyzed. After PCC case presentation, the hub team of dermatologists facilitated case-based discussion and provided the presenter with mentorship and guidance regarding diagnosis and treatment of their patient.

Comparison of lidocaine and lidocaine-xylazine for distal paravertebral anesthesia in dairy cattle.

Objective: To determine the time of onset and duration of action of distal paravertebral blocks (DPB) in dairy cattle using lidocaine and lidocaine plus xylazine (LX).

Animals: 10 healthy adult Holstein cows.

Methods: Unilateral DPB were performed in 6 cows at L1, L2, and L4.

Coaxial Flexible Fiber-Shaped Triboelectric Nanogenerator Assisted by Deep Learning for Self-Powered Vibration Monitoring.

Self-powered vibration sensor is highly desired for distributed and continuous monitoring requirements of Industry 4.0. Herein, a flexible fiber-shaped triboelectric nanogenerator (F-TENG) with a coaxial core-shell structure is proposed for the vibration monitoring.

Total flavonoids of Cynomorium songaricum attenuates cognitive defects in an Aβ 1-42 -induced Alzheimer's disease rat model by activating BDNF/TrkB signaling transduction.

Alzheimer's disease (AD) is a degenerative disorder characterized by cognitive dysfunction and BDNF/TrkB is a well-conceived anti-AD signaling. Cynomorium songaricum Rupr. ( C.

Integrating transcriptomics and genomics to identify fibroblast growth factor/receptor candidate genes for non-syndromic orofacial cleft in Chinese.

Objectives: The objective of this study was to explore the relationship between fibroblast growth factor/receptor (FGF/FGFR) and non-syndromic orofacial cleft (NSOC) in individuals of Han Chinese.

Design: Initially, we performed RNA-Seq between non-syndromic cleft lip only (NSCLO) or non-syndromic cleft palate only (NSCPO) and control groups. Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analyses were carried out to evaluate the functions of differentially expressed genes (DEGs) of FGF/FGFR.

BDMCA: a big data management system for Chinese auditing.

The advent of big data technologies makes a profound impact on various facets of our lives, which also presents an opportunity for Chinese audits. However, the heterogeneity of multi-source audit data, the intricacy of converting Chinese into SQL, and the inefficiency of data processing methods present significant obstacles to the growth of Chinese audits. In this article, we proposed BDMCA, a big data management system designed for Chinese audits.

A Multi-Strategy Improved Sparrow Search Algorithm for Coverage Optimization in a WSN.

To address the problems of low monitoring area coverage rate and the long moving distance of nodes in the process of coverage optimization in wireless sensor networks (WSNs), a multi-strategy improved sparrow search algorithm for coverage optimization in a WSN (IM-DTSSA) is proposed. Firstly, Delaunay triangulation is used to locate the uncovered areas in the network and optimize the initial population of the IM-DTSSA algorithm, which can improve the convergence speed and search accuracy of the algorithm. Secondly, the quality and quantity of the explorer population in the sparrow search algorithm are optimized by the non-dominated sorting algorithm, which can improve the global search capability of the algorithm.

Navigating the Storm: Documenting the Experience of Inpatient Registered Nurses Amid the COVID Pandemic-Palliative Care Team Insights.

Nominal research illustrates the lived experience of intensive care unit registered nurses during the COVID pandemic. Palliative care team leaders and nurse researchers designed this cross-sectional study to discover opportunities for palliative care team members to enhance the experience of nurses who cared for critically ill patients during this challenging time. The study aimed to compare the effect of caring for patients in COVID versus non-COVID units.

Clinical features and a prognostic nomogram based on the SEER database for hepatoblastoma, hepatocellular carcinoma, and embryonal sarcoma among children and adolescents.

Background: Hepatoblastoma (HB), hepatocellular carcinoma (HCC), and embryonal sarcoma (ES) are the three main types of liver tumors in children and adolescents. At present, epidemiological knowledge and predictors of these three liver tumor types in multi-ethnic populations are limited. This study aimed to outline the clinical features and construct a prognostic nomogram for these tumors, which can contribute to the prediction of dynamic overall survival probability during the follow-up period.

Insights into methanogenesis of mesophilic-psychrophilic varied anaerobic digestion of municipal sludge with antibiotic stress.

Methane production through anaerobic digestion (AD) of municipal sludge is economic and eco-friendly, which is commonly affected by temperature and pollutants residues. However, little is known about methanogenesis in psychrophilic AD (PAD) with temperature variations that simulating seasonal variations and with antibiotic stress. Here, two groups of AD systems with oxytetracycline (OTC) were operated with temperature maintained at 35 °C and 15 °C or variation to explore the influence to methanogenesis.

Effectiveness of Standard Margin Stereotactic Radiosurgery Dose to Brain Metastases.

Background: This study aims to assess efficacy of a 15-Gy margin dose in terms with the hypothesis that efficacy will be comparable with historical controls with fewer radiation-related side effects.

Methods: Patients who received single-fraction stereotactic radiosurgery (SRS) for metastatic brain tumors (prescribed 1500 cGy with 2-mm planning tumor volume) at the University of Missouri Hospital between 2004 and 2018 with at least 3 months of follow-up were retrospectively reviewed. Demographics, lesion dimensions, concurrent therapy, and treatment history before SRS were assessed.

Multi-Image Encryption Algorithm Based on Cascaded Modulation Chaotic System and Block-Scrambling-Diffusion.

To address the problem of a poor security image encryption algorithm based on a single chaotic map, this paper proposes a cascade modulation chaotic system (CMCS) that can generate multiple chaotic maps. On this basis, a multi-image encryption algorithm with block-scrambling-diffusion is proposed using CMCS. The algorithm makes full use of the features of CMCS to achieve the effect of one encryption at a time for images.

Knockdown of Piccolo in the Nucleus Accumbens Suppresses Methamphetamine-Induced Hyperlocomotion and Conditioned Place Preference in Mice.

Methamphetamine (METH), the most widely distributed psychostimulant, aberrantly activates the reward system in the brain to induce addictive behaviors. The presynaptic protein "Piccolo", encoded by Pclo, was identified as a METH-responsive protein with enhanced expression in the nucleus accumbens (NAc) in mice. Although the physiological and pathological significance of Piccolo has been identified in dopaminergic signaling, its role in METH-induced behavioral abnormalities and the underlying mechanisms remain unclear.

Guideline for the management of pediatric off-label use of drugs in China (2021).

Background: The "Law on Doctors of the People's Republic of China," which was officially implemented on March 1, 2022, emphasizes the requirements for rational drug use and the necessity for appropriate management of off-label drug use. The safety and ethical considerations related to off-label drug use are different in children than in adults. There is so far no management guideline for pediatric off-label use of drugs in China, and the applicability of foreign guidelines is limited.

Multi-Task Offloading Based on Optimal Stopping Theory in Edge Computing Empowered Internet of Vehicles.

Vehicular edge computing is a new computing paradigm. By introducing edge computing into the Internet of Vehicles (IoV), service providers are able to serve users with low-latency services, as edge computing deploys resources (e.g.

[Research hotspots and trends of Hedysari Radix: based on CiteSpace knowledge map].

This study aims to summarize the research hotspots of Hedysari Radix and predict the research trend with bibliometric methods, which is expected to serve as a reference for future research. CiteSpace V 5.8.

Repeat hospital transfers among long stay nursing home residents: a mixed methods analysis of age, race, code status and clinical complexity.

Background: Nursing home residents are at increased risk for hospital transfers resulting in emergency department visits, observation stays, and hospital admissions; transfers that can also result in adverse resident outcomes. Many nursing home to hospital transfers are potentially avoidable. Residents who experience repeat transfers are particularly vulnerable to adverse outcomes, yet characteristics of nursing home residents who experience repeat transfers are poorly understood.

A Robust Silicone Rubber Strip-Based Triboelectric Nanogenerator for Vibration Energy Harvesting and Multi-Functional Self-Powered Sensing.

Vibration is a common phenomenon in various fields which can not only indicate the working condition of the installation, but also serve as an energy source if it is efficiently harvested. In this work, a robust silicone rubber strip-based triboelectric nanogenerator (SRS-TENG) for vibration energy harvesting and multi-functional self-powered sensing is proposed and systematically investigated. The SRS-TENG consists of a silicone rubber strip and two aluminum electrode layers supported by polylactic acid (PLA), and acts as a sustainable power source and vibration frequency, amplitude and acceleration sensor as well.