Effect of COVID-19 infection on pregnant women in plateau regions.

Objective: The present study aims to explore the effect of COVID-19 infection on pregnant women in plateau regions.

Study Design: Data from 381 pregnant women infected with COVID-19 who underwent prenatal examination or treatment at Women and Children's Hospital of Tibet Autonomous Region between January 2020 and December 2022 and 314 pregnant women not infected with COVID-19 were retrospectively collected.

Methods: The study participants were divided into an infected and non-infected group according to whether they were infected with COVID-19.

Characteristics of High Altitude Pulmonary Edema in Naqu at the Altitude of 4500 m.

Background: We aimed to review records from 429 patients with high altitude pulmonary edema (HAPE) to identify some of the salient characteristics associated with this condition.

Materials And Methods: General information and clinical symptoms, along with laboratory test results from HAPE patients were collected and analyzed. Blood assay results and imaging at admission were compared with those at discharge.

Down-Regulation of EPAS1 Transcription and Genetic Adaptation of Tibetans to High-Altitude Hypoxia.

Tibetans are well adapted to the hypoxic environments at high altitude, yet the molecular mechanism of this adaptation remains elusive. We reported comprehensive genetic and functional analyses of EPAS1, a gene encoding hypoxia inducible factor 2α (HIF-2α) with the strongest signal of selection in previous genome-wide scans of Tibetans. We showed that the Tibetan-enriched EPAS1 variants down-regulate expression in human umbilical endothelial cells and placentas.

HMOX2 Functions as a Modifier Gene for High-Altitude Adaptation in Tibetans.

Tibetans are well adapted to high-altitude environments. Among the adaptive traits in Tibetans, the relatively low hemoglobin level is considered a blunted erythropoietic response to hypoxic challenge. Previously, EPAS1 and EGLN1, the major upstream regulators in the hypoxic pathway, were reportedly involved in the hemoglobin regulation in Tibetans.

[Levels of hemoglobin concentration and anemia during pregnancy in Lhasa].

Objective: To investigate the distribution of hemoglobin(Hb) and prevalence of anemia in pregnant women living in the Tibetan Plateau area.

Methods: Random sampling method was used and fingertip blood sample was tested. Related sociodemographic information was collected.