Prospects of Band Structure Engineering in MXenes for Active Switching MXetronics: Computational Insights and Experimental Approaches.

MXenes, two-dimensional (2D) transition metal carbides and nitrides, have shown promise in a variety of applications. The use of MXenes in active electronic devices is restricted to electrode materials due to their metallic nature. However, MXenes can be modified to be semiconducting and can be used for next-generation channel materials.

Sirtuin-5 Is Recruited to Hepatic Peroxisomes in Mice Fed Dodecanedioic Acid but Has Little Impact on the Peroxisomal Succinylome.

Lysine succinylation, and its reversal by sirtuin-5 (SIRT5), is known to modulate mitochondrial fatty acid β-oxidation (FAO). We recently showed that feeding mice dodecanedioic acid, a 12-carbon dicarboxylic acid (DC) that can be chain-shortened four rounds to succinyl-CoA, drives high-level protein hypersuccinylation in the peroxisome, particularly on peroxisomal FAO enzymes. However, the ability of SIRT5 to reverse DC-induced peroxisomal succinylation, or to regulate peroxisomal FAO in this context, remained unexplored.

Three-dimensional movement and distribution of Tribolium castaneum (Coleoptera: Tenebrionidae) and Cryptolestes ferrugineus (Coleoptera: Laemophloeidae) in stored wheat at different temperatures and at different times.

Understanding the movement and distribution patterns of insects is crucial for developing effective stored grain management protocols. This research investigates 3-dimensional movement and distribution of Tribolium castaneum (Herbst) and Cryptolestes ferrugineus (Stephens) separately at different temperatures (5, 10, 20, and 30°C) and for different movement periods (1, 2, 3, and 24 h) in stored wheat with a uniform moisture content of 14.5% (wet basis).

Evolution of Bionanocomposites: Innovations and Applications in Food Packaging.

Bionanocomposites are emerging as a pivotal innovation in sustainable food packaging, leveraging the strengths of biopolymers enhanced with nanoparticles for improved functionality. The increasing demand for sustainable packaging solutions, coupled with advancements in nanotechnology, has driven research in this field over the past decade. This review covers the full spectrum of developments in the field, from the classification and synthesis of bionanocomposites to their applications in food packaging and current research trends.

The Challenge of External Generalisability: Insights from the Bicentric Validation of a [Ga]Ga-PSMA-11 PET Based Radiomics Signature for Primary Prostate Cancer Characterisation Using Histopathology as Reference.

: PSMA PET radiomics is a promising tool for primary prostate cancer (PCa) characterisation. However, small single-centre studies and lack of external validation hinder definitive conclusions on the potential of PSMA PET radiomics in the initial workup of PCa. We aimed to validate a radiomics signature in a larger internal cohort and in an external cohort from a separate centre.

Association Between Type 2 Diabetes and Hypogonadism in India: An Observational Study.

Introduction: Hypogonadism is a common comorbidity associated with several metabolic disorders including type 2 diabetes (T2D) that can remain undetected without proper screening. Here, we evaluated the prevalence of hypogonadism in Indian male patients with T2D with or without obesity.

Methods: In this prospective, observational study, male patients with T2D and hypogonadism were evaluated symptomatically using the androgen deficiency in ageing male (ADAM) questionnaire at baseline and confirmed on the basis of total testosterone (TT) levels (<300 ng/dL) at Days 5-7 (Visit 2) and 9-14 (Visit 4) assessed after 12 hours of fasting between 8 AM and 10 AM.

Pluronic F-127 coated zinc oxide nanoparticles from : a comprehensive assessment of antibacterial, and anticancer activities.

The study synthesized Pluronic F-127 coated zinc oxide nanoparticles (PF-127ZnO NPs) using leaf extract and evaluated their antibacterial, antioxidant, and anticancer properties using various characterization methods such as UV-Vis, Fourier Transform Infra-Red, Photoluminescence spectroscopy, FESEM, EDAX, TEM, SAED, XRD, and DLS. The disc diffusion technique was used to evaluate the antibacterial properties of synthesized Pluronic F-127 coated zinc oxide nanoparticles against various pathogens and significant anticancer activity was noticed. The study examined the cytotoxicity of PF127ZnO nanoparticles to Hep3B cells .

Application of natural solar photocatalytic and DSSC's studies AC loaded on Ag-InO nanoparticles by hydrothermal approach.

Contaminants are repeatedly being released into the land, water and air about the world as a consequence of the high levels of human movement and development, which causes a fast an increase in the growing of pollution. In this assessment, activated charcoals supported on Ag-InO nanomaterials were blended by hydrothermal system. The morphology constitution, surface assets and optical description of synthesized nanomaterials were characterized by XRD, UV-DRS, PL, HR-SEM and EDAX, HR-TEM, SAED pattern, FT-IR, XPS, BET, CV and VSM techniques.

Therapeutic targeting of the oxidative stress generated by pathological molecular pathways in the neurodegenerative diseases, ALS and Huntington's.

Neurodegenerative disorders are characterized by a progressive decline of specific neuronal populations in the brain and spinal cord, typically containing aggregates of one or more proteins. They can result in behavioral alterations, memory loss and a decline in cognitive and motor abilities. Various pathways and mechanisms have been outlined for the potential treatment of these diseases, where redox regulation is considered as one of the most common druggable targets.

Role of macroalgal blue carbon ecosystems in climate change mitigation.

This review explicitly emphasizes the important yet unnoticed potential of macroalgae, such as seaweeds and kelps, as a powerful nature-based solution for climate change mitigation, with greater focus on the Indian Ocean seaweed diversity and efforts towards their conservation and management. Despite the IPCC's recognition of Blue Carbon ecosystems, seaweed ecosystems remain largely excluded from carbon accounting and policy frameworks. Herein, we specifically focus on the immense capacity of macroalgae globally and in the Indian Ocean coastal communities to sequester carbon, support marine biodiversity, and provide a range of ecosystem services.

Enhancing tomato shelf life using isolated cellulose fibers from Asian Palmyra palm coated with garlic oil.

In this study, garlic-oil-combined cellulose fibers were prepared by using Borassus flabellifer (Asian Palmyra palm) to enhance the post-harvest shelf life of tomatoes. The physicochemical properties of the prepared cellulose fibers were characterized by using X-ray diffraction (XRD), Fourier-transform infrared spectroscopy (FTIR), and field emission scanning electron microscopy (FE-SEM). The B.

Activation of the yeast MAP kinase, Slt2, protects against TDP-43 and TDP-25 toxicity in the Saccharomyces cerevisiae proteinopathy model.

TDP-43 proteinopathy is observed in human neurodegenerative diseases like ALS. Heterologous TDP-43 expression in the yeast model also mimics several proteinopathy features such as cytotoxicity, cytoplasmic mis-localization and oxidative stress. Among the pathways implicated in modulating the TDP-43 toxicity in yeast, the unfolded protein response (UPR) activation was also identified.

Synthesis and Structural Characterization of SiO Nanoparticles Using Extract of Gracilaria Crassa Via Green Chemistry Approach.

Biologically synthesized nanoparticles via biological entities are produced with less negative impact on the environment and without expensive chemicals, which have biocompatibility and are eco-friendly. Gracilaria crassa is a well-known marine red alga that is edible and unique and is the commercial source of agar and agarose production. In this work, Gracilaria crassa-mediated SiO NPs were synthesized by the green synthesis method.

FPGA-based low-light image enhancement using Retinex algorithm and coarse-grained reconfigurable architecture.

Advancements in digital imaging and video processing are often challenged by low-light environments, leading to degraded visual quality. This affects critical sectors such as medical imaging, aerospace, and underwater exploration, where uneven lighting can compromise safety and clarity. To enhance image quality in low-light conditions using a computationally efficient system.

Antibacterial Activity, GC MS Analysis and In Silico Validation of Bioactive Compound from Endophytic Fungus Lasiodiplodia pseudotheobromae EF-9.

Secondary metabolites synthesized by endophytic fungi have garnered significant interest for their broad applications in treating various ailments. In this study involving 20 plant samples, 11 endophytic fungi were isolated and cultured, and Lasiodiplodia pseudotheobromae EF-9, derived from Hibiscus rosa-sinensis, demonstrated greater antibacterial efficacy than the other isolated endophytes. Phylogenetic analyses using 18S rRNA gene confirmed the EF-9 identity as L.

Development and validation of HPLC-UV and LC-MS/MS methods for the quantitative determination of a novel aminothiazole in preclinical samples.

Aminothiazoles are the important class of chemical groups which have proven their broad range of biological activities. A novel aminothiazole (21MAT) was quantified in analytical solutions using a high-performance liquid chromatography (HPLC) approach that was developed and partially validated for the analysis of in vitro experimental samples. An isocratic elution on reverse phase Phenomenex Luna C (50 mm × 4.

Carboplatin-loaded zeolitic imidazolate framework-8: Induction of antiproliferative activity and apoptosis in breast cancer cell.

The challenge with breast cancer is its ongoing high prevalence and difficulties in early detection and access to effective care. A solution lies in creating tailored metal-organic frameworks to encapsulate anticancer drugs, enabling precise and targeted treatment with less adverse effects and improved effectiveness. Zeolitic imidazolate framework-8 (ZIF-8) and carboplatin (CP)-loaded ZIF-8 were synthesized and characterized using various analytical techniques.

Loss of long-chain acyl-CoA dehydrogenase protects against acute kidney injury.

Proximal tubular epithelial cells (PTECs) are particularly vulnerable to acute kidney injury (AKI). While fatty acids are the preferred energy source for PTECs via fatty acid oxidation (FAO), FAO-mediated H O production in mitochondria has been shown to be a major source of oxidative stress. We have previously shown that a mitochondrial flavoprotein, long-chain acyl-CoA dehydrogenase (LCAD), which catalyzes a key step in mitochondrial FAO, directly produces H O .

Development of Chitosan-Coated Graphene Oxide and Iron Oxide Nanocomposites for Targeted Delivery of Camptothecin to Liver Cancer Cells.

Innovative drug delivery platforms for selective, regulated, and sustained release of anticancer drugs are crucial in cancer treatment. This study presents nanoparticles developed from chitosan (CS), graphene oxide (GO), and magnetite (FeO), and their nanocomposites to enhance the loading and release efficiency of camptothecin (CPT). Nanostructures were characterized using imaging microscopy, FT-IR, and X-ray diffraction, with an average crystallite size of 5.

Benign Giant Phyllodes Tumours Presenting as Fungating Breast Masses.

Breast masses presenting as fungating growths usually represent advanced malignancy. One remarkable exception is a benign phyllodes tumour. These tumours of stromal origin often exhibit rapid growth, resulting in pressure necrosis at the summit of the tumor causing fungation.

Comparative analysis of direct coupling and MPPT control in standalone PV systems for solar energy optimization to meet sustainable building energy demands.

Solar energy, a prominent renewable source, has reached an installed capacity of 71.78 GW in India. This research explored the load demands of the computer center at an engineering college in Tanjore, Tamil Nadu, India.

Sirt2 Regulates Liver Metabolism in a Sex-Specific Manner.

Sirtuin-2 (Sirt2), an NAD+-dependent lysine deacylase enzyme, has previously been implicated as a regulator of glucose metabolism, but the specific mechanisms remain poorly defined. Here, we observed that males, but not females, have decreased body fat, moderate hypoglycemia upon fasting, and perturbed glucose handling during exercise compared to wild type controls. Conversion of injected lactate, pyruvate, and glycerol boluses into glucose via gluconeogenesis was impaired, but only in males.