[Effect of the use of lidocaine on patients with acute myocardial infarct].

In 411 patients with acute myocardial infarction (AMI) the effect of intravenous lidocaineeee administration was studied in a suboptimal dose - under 1,5 mg/min (to 1979) and in the optimal dose - over 1,5 mg/min, minimum 2 mg/min during the first 12 hours, with an average 24 h dose, 3,0 g in the course of 48 hours. The patients were grouped into three prognostic groups, depending on their initial assessment according to the coronaryprognostic index of M. R.

[Urinary catecholamine excretion and cardiac output in hypertensive patients].

Cardiac output was determined to 70 patients with hypertonic disease I, II and III stage by dye-dilution method and urine excretion of adrenaline and noradrenaline was determined by fluorescence method. The extent of stroke and minute volume was determined depending on the stage of the disease, degree of arterial hypertension and patients' age. Noradrenaline excretion was normal in 75.

[Clinical and hemodynamic characteristics of the decompensation syndrome in patients with congestive cardiomyopathy].

Thirty seven patients were clinically and hemodynamically studied under hospital conditions. The stage of cardiomegaly, the stasis in the pulmonary and systemic circulations were followed up as well as the presence of manifestations of pulse deficit, incidence of gallop rhythm manifestation. It was established that in the patients with II-A stage of decompensation of circulation, a decreased cardiac output was found, enhanced peripheral resistance and normovolemia.

[Clinical and hemodynamic effect of molsidomine in patients with unstable angina pectoris].

In 30 patients with a grave form of ischemic heart disease--unstable angina pectoris, peroral treatment with molsidomin (Corvaton) was carried out in a dose I table of 20 mg, three times daily, in the course of 33 days at an average. The incidence, intensity and duration of stenocardiac paroxysms were followed up as well as the nitroglycerine need- and electrocardiographic changes. The main hemodynamic indices, prior to and post treatment, were also determined.

[Causes of early mortality in myocardial infarct].

The causes of lethality were studied in 49 patients with acute myocardial infarction of an average age 71.24 +/- 12.12.

[Intracardiac hemodynamic characteristics in high-degree mitral stenosis and an assessment of the indications for its surgical treatment].

The data from the right cardiac catheterization, echocardiography M-type and radiocardiography were juxtaposed in 54 patients with "pure" or predominating severe mitral stenosis (MS)(mitral valvular opening under 1 cm2)--confirmed at operation, in the determination of their functional and hemodynamic characteristics. The patients were grouped into three groups depending on the degree of pulmonary--capillary pressure increase (PC)--greater than 2.666, greater than 3.

[Retrospective assessment of the preinfarction period].

The prodromal symptoms were retrospectively assessed in 100 patients with acute infarction of myocardium. The authors found preinfarction state in 48 per cent of the patients. In 95 per cent of the cases pain paroxysm was the basic manifestation.

[Clinical dynamic ECG observations of the physical load tolerance of myocardial infarct patients].

Dynamic ECG observations are reported after a full day interval motor programme, applied with four motor regimes on patients with myocardial infarction under clinical conditions. The motor programme was used for the treatment of 241 patients, distributed into 2 groups. Observation on the effect of peak physical loading at the end of each motor regime was also reported.

[201T1 study of regional myocardial perfusion using a gamma counter and the EC1020 computer].

Myocardial perfusion was followed up after 500-1000 muCi 201TI-chloride injection at a gamma camera Pho-Gamma HP, Nuclar, Chicago with 4060 channel analyser and the images, according to the programmes of the authors, were processed with a computer type EC 1020. Some of the patients were examined by removing the detector, aiming at magnifying of the image and enhancing the differentiation ability under I cm. In some borderline cases, the patients were examined under physical loading and at rest for the differentiation of the normal from the disperfusion myocardial zones.

[Peroral use of a lidocaine preparation].

The authors studied the therapeutic effect of lidocainee peroral forms in case of rhythm disorders, accompanying with various cardiac diseases. The results obtained revealed that in 76 per cent of the cases with ventricular extrasystoles, the treatment result was very good, with complete disappearing of extrasystoles. Good effect was found in 18 per cent, with the recording of some rare, single extrasystoles towards the end of the treatment, and the treatment had no effect on 6 per cent of the patients.

[Comparative evaluation of the radiocardiographic and the dye dilution methods of determining cardiac output and circulating blood volume].

The authors compared the radiocardiographic and dye-dilution methods for hemodynamics determination. Cardiac capacity and volume of circulating blood were determined in 42 patients with atherosclerotic myocardiosclerosis and acquired valvular defects. A very high correlation dependence was established between the two methods.

[Left atrial thrombi manifesting clinically as an annular thrombus].

The authors present a case diagnosed while still living, as an annular thrombus in the left atrium with the presence of a "pure" mitral stenosis. At necropsy, two thrombi were found, one of them "traveling", situated very close to each other, providing conditions for a complete obstruction of the mitral opening and imitating the respective clinical picture.

[Changes in the hemodynamic indices in the subacute stage of myocardial infarct before and after bicyle ergometry].

The basic hemodynamic indices: cardiac volume, volume of circulating plasma and blood, total peripheral vascular resistance and velolity of blood flow were studied in 60 patients with myocardial infarction, subacute stage in progress, prior to and post veloergometric loading. A decreased tolerance to physical loading was established: cardiac index--insignificantly increased, beat volume-decreased, volume of circulating plasma and blood--tendency to increase. The results show a dependence on the clinical development of the disease--the signs of a latent insufficiency being manifested in the cases with extensive localization of the infarction, transmural affection and with a formed aneurisma after a dosed loading.

[Disordered alveolar-capillary gas metabolism in the acute stage of myocardial infarct].

The alveolar-capillary gas metabolism was studied in 60 patients with acute myocardial infarction. Arterial hypoxemia and hypocapnia were observed in the majority of the patients. Those disturbances are more pronounced in the presence of cardiac insufficiency.

[Changes in uricemia in acute myocardial infarct].

The authors studied in dynamics the concentration of uric acid in 84 patients in the acute stage of myocardial, in 28 patients with non-stable stenocardia. The average value of uricemia, in the first 1--2 days post infarction is 6.35 +/- 2.

[Sick sinus node syndrome and the transitory collapse of the R wave in myocardial infarct].

The authors observed 40 patients (7.79%) with the morbid sinus node syndrome among the treated 526 patients with acute myocardial infarction at the department of intensive care during the period 1973--1976. Thirty one were males and nine--females.

[Analysis of hospital mortality in myocardial infarct].

Hospital lethality was studied in myocardial infarction which was 24.9 per cent for the period 1973--1976 with a decreasing tendency during the last two years. The study covers 134 deceased of myocardial infarction at an average age of 70,78, their pathologoanatomical findings in the coronary arteries and localization of the nectrotic zone.

[Changes in myocardial contractile function and in the hemodynamic indices in patients with myocardial infarct before and after beta-blockader treatment].

The changes in the basic hemdynamic indices and in the phase structure of the cardiac cycle in patients with acute infarction prior to and post treatment with beta-blockers (Obsidan and Trasicor) were studied. Manifested changes in the hemodynamics were established, namly: pulse rate and cardiac flow decrease, the total peripheral resistance grows; veloqcilty of blood flow is slowed down. The preparations used have a negative effect upon the phase structure of left ventricle as well.