Corticosteroid feedback: II. Role of hypothalamus and hypophysis.

The role of the paraventricular nucleus (PVN) of the hypothalamus and the hypophysis in ensuring the corticosteroid feedback of the pituitary-adrenocortical system (PACS) in rats was characterized by administration of increasing doses of hydrocortisone. The doses 100, 300 and 1200 micrograms/100 g b.w.

Corticosteroid feedback: I. General characteristics, role of adrenal cortex.

The dependence of the basal corticosterone content, the stress-induced response of the pituitary-adrenocortical system (PACS) and ACTH-induced adrenal response on different doses of hydrocortisone has been studied in rats. PACS and adrenal responses were estimated by the corticosterone content in blood. Hydrocortisone was administered intraperitoneally in the dose of 100 micrograms/100 g b.