Background: Tibia plateau fractures are most commonly managed with open reduction and internal fixation (ORIF) technique, external fixation via minimally invasive technique are an excellent alternative. The aim of this study was to assess the results of tibia plateau fractures by using the Ilizarov external fixator. The analysis was done both clinically and radiologically.
View Article and Find Full Text PDFThe treatment of central nervous system (CNS) disorders always remains a challenge for the researchers. The presence of various physiological barriers, primarily the blood-brain barrier (BBB) limits the accessibility of the brain and hinders the efficacy of various drug therapies. Hence, drug targeting to the brain, particularly to the diseased cells by circumventing the physiological barriers is essential to develop a promising therapy for the treatment of brain disorders.
View Article and Find Full Text PDFSpectrochim Acta A Mol Biomol Spectrosc
April 2015
Density functional theory (DFT) and phytochemical study of a natural product, Diospyrin (DO) have been carried out. A suitable level of theory was developed, based on correlating the experimental and theoretical data. Hybrid DFT method at B3LYP/6-31G (d,p) level of theory is employed for obtaining the electronic, spectroscopic, inter-molecular interaction and thermodynamic properties of DO.
View Article and Find Full Text PDFObjective: To compare the serum nicotine levels in smokers, passive smokers and those with no exposure to cigarette smoke.
Methods: The comparative study spanning two years was conducted in Ziauddin Medical University, Karachi, in collaboration with HEJ Research Institute of Chemical Sciences, University of Karachi from 2009 to 2011 involved 135 self-reported smokers, never smokers and passive smokers among whom serum nicotine was analysed using 17-A gas chromatograph with flame ionisation detector equipped with Supelco SPB-5 fused silica capillary column (45m x 0.53mm id and 0.