Photoprotection and antioxidant activity of eumelanin from Streptomyces lasalocidi NTB 42 and its photoprotective effects on Schizosaccharomyces pombe ARC039.

This study evaluated the photoprotective and antioxidant properties of eumelanin derived from Streptomyces lasalocidi NTB 42 (eumelanin NTB 42). This study also investigated the cellular-level photoprotective effects of eumelanin using Schizosaccharomyces pombe ARC039 as a model organism and its ability to enhance the Sun Protection Factor (SPF) of commercial sunscreens. The thermal and light stability and total phenolic and flavonoid contents were analyzed.

Immediate Effect of on Heart Rate Variability in Patients with Hypertension: A Randomised Controlled Study.

Background: Hypertension, a prevalent cardiovascular condition, is linked to autonomic nervous system dysregulation, often evidenced by reduced heart rate variability (HRV). Yoga, particularly , may influence autonomic control and improve HRV, thus offering potential benefits for hypertension management.

Purpose: This study intended to assess the impact of the regular use of practice on HRV among hypertensive patients.

Policy to Expand Accessing Antimalarial Drug Treatment in Papua Region-Indonesia: Who Should Be the Target?

The Papua region of Indonesia faces a substantial burden of malaria cases. To broaden the understanding of factors influencing access to antimalarial drug treatment, researchers analyzed the 2018 Indonesia Basic Health Survey data. Their examination encompassed demographics, socioeconomic elements, and transportation expenses.

Water pollution and sanitation in Indonesia: a review on water quality, health and environmental impacts, management, and future challenges.

As an archipelagic tropical developing country, Indonesia is characterized by vast expanses of rural and isolated areas. This review aims to discuss water pollution and sanitation's existing condition, health, and environmental impacts, alongside its management and challenges in Indonesia. The systematic review approach was utilized to ensure transparency and replicability, following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) criteria.

Testosterone hormone levels and breast muscle performance of Pelung chickens after zinc sulfate and synthetic testosterone supplementation.

Background And Aim: Pelung chicken (Linnaeus, 1758) is a chicken endemic to Cianjur, West Java, Indonesia. This study aimed to determine the effects of zinc sulfate (ZnSO) and synthetic testosterone supplementations for 56 days on testosterone hormone levels and breast muscle performance in Pelung chickens.

Materials And Methods: This study used 12 Pelung chickens with three treatment groups (G) and four replications, namely, control (G0), ZnSO 0.

Atopic Dermatitis Immune Dysregulation as Dengue Predisposing Factor.

Introduction: The immune response is important in dengue's clinical manifestation, and the immune dysregulation in Atopic Dermatitis (AD) can permit immune evasion by viruses. There have been many studies describing the immune response in AD and the pathomechanism of dengue, but AD as a predisposing factor for dengue and its severity have not been much discussed. This review investigates how immune dysregulation in AD may be a predisposing factor for Dengue and its severe outcomes.

Identification of novel 3D-genome altering and complex structural variants underlying retinitis pigmentosa type 17 through a multistep and high-throughput approach.

Introduction: Autosomal dominant retinitis pigmentosa type 17 (adRP, type RP17) is caused by complex structural variants (SVs) affecting a locus on chromosome 17 (chr17q22). The SVs disrupt the 3D regulatory landscape by altering the topologically associating domain (TAD) structure of the locus, creating novel TAD structures (neo-TADs) and ectopic enhancer-gene contacts. Currently, screening for RP17-associated SVs is not included in routine diagnostics given the complexity of the variants and a lack of cost-effective detection methods.

Lipopeptide-mediated Cas9 RNP delivery: A promising broad therapeutic strategy for safely removing deep-intronic variants in .

Deep-intronic (DI) variants represent approximately 10%-12% of disease-causing genetic defects in -associated Stargardt disease (STGD1). Although many of these DI variants are amenable to antisense oligonucleotide-based splicing-modulation therapy, no treatment is currently available. These molecules are mostly variant specific, limiting their applicability to a broader patient population.

Comparative Analysis of Volatile Compounds and Biochemical Activity of Roxb. Essential Oil Extracted from Distinct Shaded Plants.

The application of shade during plants' growth significantly alters the biochemical compounds of the essential oil (EO). We aimed to analyze the effect of shade on the volatile compounds and biochemical activities of EO extracted from Roxb. () plants.

Exome variant prioritization in a large cohort of hearing-impaired individuals indicates IKZF2 to be associated with non-syndromic hearing loss and guides future research of unsolved cases.

Although more than 140 genes have been associated with non-syndromic hereditary hearing loss (HL), at least half of the cases remain unexplained in medical genetic testing. One reason is that pathogenic variants are located in 'novel' deafness genes. A variant prioritization approach was used to identify novel (candidate) genes for HL.

Calcified Maxillary Fibroma in a Patient on Hemodialysis for Seven Years.

Background: The presentation of mineral bone disorder (MBD) in individuals with chronic kidney disease (CKD) may vary. Consequently, physicians should be capable of recognising this condition when there is a suspicion of its existence. This case report will describe a calcified maxilla tumour as a manifestation of CKD-MBD.

Clinical exome sequencing data from patients with inborn errors of immunity: Cohort level diagnostic yield and the benefit of systematic reanalysis.

While next generation sequencing has expanded the scientific understanding of Inborn Errors of Immunity (IEI), the clinical use and re-use of exome sequencing is still emerging. We revisited clinical exome data from 1300 IEI patients using an updated in silico IEI gene panel. Variants were classified and curated through expert review.