Long-read sequencing of hundreds of diverse brains provides insight into the impact of structural variation on gene expression and DNA methylation.

Structural variants (SVs) drive gene expression in the human brain and are causative of many neurological conditions. However, most existing genetic studies have been based on short-read sequencing methods, which capture fewer than half of the SVs present in any one individual. Long-read sequencing (LRS) enhances our ability to detect disease-associated and functionally relevant structural variants (SVs); however, its application in large-scale genomic studies has been limited by challenges in sample preparation and high costs.

Viral infections in celiac disease: what should be considered for better management.

Following a gluten-free diet (GFD) is known as the main effective therapy available for celiac disease (CD) patients, which in some cases is not enough to heal all patients presentations completely. Accordingly, emerging researchers have focused on finding novel therapeutic/preventive strategies for this disorder. Moreover, previous studies have shown that celiac patients, especially untreated subjects, are at increased risk of developing viral and bacterial infections, which can become a challenge for the clinician.

Acute effect of exercise on appetite-related factors in males with obesity: A pilot study.

To investigate the role of appetite-related factors, including interleukin 6 (IL-6), irisin, interleukin 7 (IL-7), neuropeptide Y (NPY), and leptin, on appetite perception in males with obesity. Eleven males (BMI 35.3 ± 4.

Advances in structural modification of fucoidans, ulvans, and carrageenans to improve their biological functions for potential therapeutic application.

Marine sulfated polysaccharides constitute a class of bioactive polymers commonly found in cell walls of macroalgae. Among these macromolecular substances, fucoidans, ulvans, and carrageenans have attracted considerable attention providing interesting therapeutic properties affected by a combination of various structural factors, such as sulfation pattern, molecular weight, monosaccharide composition, and glycosidic linkages. Remarkably, chemical modification, enzymatic hydrolysis and crosslinking are promising approaches for developing the application of these polysaccharides through enhancement and/or addition of new biological properties.

Electrospun Poly(vinyl Alcohol)/Chitin Nanofiber Membrane as a Sustainable Lithium-Ion Battery Separator.

Commercial battery separators are made of polyolefin polymers due to their desired mechanical strength and chemical stability. However, these materials are not biodegradable and are challenging to recycle. Considering the environmental issues from polyolefins, biodegradable polymers can be developed as separators to reduce the potential waste from polyolefin separators.

Development of three-layer microneedle system for controlled and sustained release of Levonorgestrel: A pioneering approach to long-term contraceptive delivery.

The increasing prevalence of unintended pregnancies, a persistent issue affecting public health and hindering progress towards the Sustainable Development Goals (SDGs), highlights the critical need for innovative contraceptive approaches. While current methods, including hormonal contraceptives such as levonorgestrel (LNG), offer potential solutions, challenges like limited access and inconsistent use persist. This study introduces a new approach with the development of a three-layer microneedle (TIMN) containing LNG designed to provide extended contraceptive efficacy.

Guillain-Barré Syndrome in Africa: Understanding, Addressing, and Empowering.

Introduction: Guillain-Barré Syndrome (GBS) is a spectrum of peripheral neuropathies characterized by rapid symmetrical limb weakness and sensory symptoms. GBS can be life-threatening and requires intensive care, particularly for patients with imminent respiratory failure. In Africa, limited research and high therapy costs pose challenges.

Effective and ineffective psychological adjustment in breast cancer patients before receiving neoadjuvant chemotherapy: insights from a cohort study.

Background: The timing of a breast cancer (BC) diagnosis has a significant psychological impact on patients. However, it reported that those eligible for treatment regimens based on neoadjuvant chemotherapy may experience high levels of depression, anxiety and distress. To cope with this situation, patients deploy psychological coping strategies.

Knowledge of emergency nurses and related factors toward geriatric: a cross-sectional study.

Background: This study aimed to evaluate the geriatric knowledge of emergency nurses and related factors.

Materials And Methods: This cross-sectional study was conducted on nursing students at Guilan University of Medical Sciences in Iran. The objective was to assess the geriatric knowledge of nurses working in the emergency departments of educational and therapeutic centers in Rasht City.

Effect of peer facilitation in anatomy small group curriculum on academic performance and retention: A pilot study.

Peer-assisted learning and group facilitation have been proven to foster active participation in small-group learning, and these effective teaching modalities have been shown to enhance learning outcomes. This study introduced a student peer facilitator role in an anatomy small-group curriculum for pre-clerkship medical students and explored its impact on academic performance and retention. Students were required to rotate through this facilitator role and lead their small group during their designated sessions.

Teaching teen titans: An anatomy curriculum using superheroes for middle- and high school students in health professions outreach programs.

Health professions outreach programs are important avenues to increase interest in the fields of science, technology, engineering, and mathematics (STEM). One aspect of many of these programs is anatomy, which can be challenging to teach due to its scope. Creative teaching methods, such as the incorporation of examples from pop culture, can help students better access complex scientific concepts.

Evaluation of Phytochemical Content and In Vitro Antioxidant Activities of L. Leaves Extracts, a Medicinal Plant From the Beni-Snassen Forest (Eastern Region of Morocco).

A medicinal plant from the Beni-Snassen Forest in the eastern region of Morocco has been studied. This scientific research was carried out to measure the content of essential phytochemical constituents and their antioxidant capacities from the hydromethanolic extract of leaves of L. located on sites at varying levels of altitudes.

Review on Biodegradable Aliphatic Polyesters: Development and Challenges.

Biodegradable polymers are gaining attention as alternatives to non-biodegradable plastics to address environmental issues. With the rising global demand for plastic products, the development of non-toxic, biodegradable plastics is a significant topic of research. Aliphatic polyester, the most common biodegradable polyester, is notable for its semi-crystalline structure and can be synthesized from fossil fuels, microbial fermentation, and plants.

Experiences of Male Indonesian Migrant Workers During the COVID-19 Pandemic to Post-Pandemic Period in Taiwan: A Phenomenological Study.

Introduction: The challenges faced by male migrant workers during the pandemic have not been fully understood. This study aimed to explore the experiences of male Indonesian migrant workers during the COVID-19 pandemic in Taiwan.

Methodology: This study used an interpretive phenomenological design.

Improving the Mechanical Properties of Glass Ionomer Cement With Nanocrystalline Cellulose From Rice Husk.

This study aimed to evaluate the effect of incorporating nanocrystalline cellulose (NCC) sourced from rice husk on the mechanical properties of a commercial glass ionomer cement (GIC). NCC was isolated through acid hydrolysis, and its crystallinity, chemical structure, and morphology were characterized through x-ray diffractometry, Fourier-transform infrared spectroscopy, and transmission electron microscopy, respectively. Various concentrations of NCC (0%, 0.

Marrow talaromycosis as the initial presentation in a case of Burkitt lymphoma.

Talaromyces marneffei is a thermally dimorphic fungus which causes opportunistic infections in immunocompromised individuals. The diagnosis of T. marneffei infection rests on the microscopic demonstration of the fungus in the tissues and/or isolation of the fungus from clinical specimens.

Investigating Contrastive Pair Learning's Frontiers in Supervised, Semisupervised, and Self-Supervised Learning.

In recent years, contrastive learning has been a highly favored method for self-supervised representation learning, which significantly improves the unsupervised training of deep image models. Self-supervised learning is a subset of unsupervised learning in which the learning process is supervised by creating pseudolabels from the data themselves. Using supervised final adjustments after unsupervised pretraining is one way to take the most valuable information from a vast collection of unlabeled data and teach from a small number of labeled instances.

The Effect of Photobiomodulation and on THP-1 Derived Macrophage Polarization Treated with Gliadin Peptide.

Photobiomodulation (PBM) and have been shown to be effective in improving inflammatory conditions with positive effects on increasing the population of anti-inflammatory M2 macrophages (MQs). In this study, gliadin-stimulated THP-1 derived MQs were treated with and PBM to evaluate their effects on promoting the polarization of M2 MQs. The human monocyte cell line (THP-1) was differentiated to MQs.