Impact of Parental Time-Restricted Feeding on Offspring Metabolic Phenotypic Traits.

Intermittent fasting (IF) is widely recognized for its numerous health benefits, yet its impact on metabolic health across generations remains relatively unexplored. This study investigates the intergenerational effects of parental IF, specifically through 8-hour daily time-restricted feeding, on the metabolic health of offspring. By examining four different combinations of parental mating groups, we demonstrate that parental IF can influence offspring metabolic health in distinct ways.

Effectiveness of Various Light-Cure Biomaterials as an Intraorifice Barrier: An In Vitro Study.

Objective Proper seal achieved via placement of an effective intraorifice barrier curtails the occurrence of post-bleaching consequences and reinforces the cervical tooth structure. Hence, our present study aims to evaluate the effectiveness of three different light-cure biomaterials as an intraorifice barrier. Methodology Forty-eight sound human premolars were obtained, and root canal treatment procedures were accomplished according to the standard protocol.

Digit Ratio as Predictors of Dental Caries: A Study of the 2D:4D Relationship.

Aim: This cross-sectional study aimed to investigate the association between caries risk and the 2D:4D ratio, a potential marker of prenatal hormone exposure, among children aged 5-12 years.

Methods: A total of 250 children were examined. Caries indices decayed, missing and filled teeth/decayed, extracted and filled teeth (DMFT/deft) were recorded, and 2D:4D ratios were measured using a vernier caliper.

Assessment of Knowledge, Attitude, and Practice about "SADE" Among Dentists - A Cross-Sectional Study.

Background: Intellectual and developmental disabilities (IDDs), including autism spectrum disorder (ASD), often lead to sensory challenges and dental anxiety, complicating oral healthcare. Sensory adapted dental environment (SADE) can alleviate anxiety and enhance cooperation during dental procedures, but awareness and implementation among dentists remain limited.

Objective: To assess general dentists' knowledge, attitudes, and practices regarding SADE and identify gaps for targeted educational programs.

Current Status of Knowledge, Attitude, and Perspective of Dental Practitioners Toward Stem Cell Uses in Dentistry.

Aim: The purpose of this study was to evaluate dentists' attitudes and level of knowledge about dental stem cells.

Material And Methods: Five hundred dentists from Tamil Nadu, India, took part in a cross-sectional descriptive questionnaire-based survey that assessed knowledge, attitudes, and practices. For statistical analysis, percentages of the total and Pearson's Chi-square test were employed.

Plant extracts as a source of antiviral agents against influenza A virus.

The influenza virus, especially influenza A (IAV), has remained a constant global health threat due to its high morbidity rate and ability to undergo antigenic shifts and drifts, causing pandemics and epidemics. Due to the rapid evolution of IAV, novel therapeutics are urgently required to combat these viruses effectively, as they develop resistance against current therapeutics. Natural products have been the subject of debate for alternative IAV therapy, where the abundance of bioactive compounds offers numerous potentials for novel anti-IAV drug discovery.

Hybrid ladybug Hawk optimization-enabled deep learning for multimodal Parkinson's disease classification using voice signals and hand-drawn images.

PD is a progressive neurodegenerative disorder that leads to gradual motor impairments. Early detection is critical for slowing the disease's progression and providing patients access to timely therapies. However, accurately detecting PD in its early stages remains challenging.

QSAR, Antimicrobial, and Antiproliferative Study of (/)-2-Thioxo-3,4-dihydropyrimidine-5-carboxanilides.

Owing to the significant contribution of three-dimensional (3D) field-based QSAR toward hit optimization and accurately predicting the activities of small molecules, herein, the 3D-QSAR, in vitro antimicrobial, molecular docking, and pharmacophore modeling studies of all the isolated (/)-2-thioxo-DHPM-5-carboxanilides exhibiting antimicrobial activity were carried out. The screening process was performed using 46 compounds, and the best-scoring model with the top statistical values was considered for bacterial and fungal targets and . As a result of 3D-QSAR analysis, compound -()- and -()-isomers were found to be more potent compared to the standard drugs tetracycline and fluconazole, respectively.

Integrated one-pot green fractionation of Madhuca indica seed: Green fractionation of lignocellulosic macromolecules into value-added products.

The depletion of fossil resources, the energy crisis, and environmental pollution have become the main drivers for transitioning from a linear petroleum refinery to a sustainable biorefinery. In the current scenario, the global scientific community is focused on developing a sustainable and green environment. To this end, exclusive efforts have been made in waste valorization and management.

Transient colloidal crystals fueled by electrochemical reaction products.

Conventional electric field directed colloidal assembly enables fabricating ordered structures but lacks temporal control over assembly state. Chemical reaction networks have been discovered that transiently assemble colloids; however, they have slow dynamics (hrs - days) and poor temporal tunability, utilize complex reagents, and produce kinetically trapped states. Here we demonstrate transient colloidal crystals that autonomously form, breakup, and reconstitute in response to an electrochemical reaction network driven by a time invariant electrical stimulus.

Larvicidal Efficacy of Chloris virgata Extracts Against Aedes aegypti, Anopheles stephensi, and Culex quinquefasciatus with Insights into Mode of Action via Molecular Docking.

The indiscriminate use of synthetic insecticides for mosquito control has resulted in significant challenges, such as environmental pollution and growing insecticide resistance. In response, there is increasing interest in eco-friendly alternatives like plant-based larvicides. This study assesses the larvicidal efficacy of Chloris virgate (Poales: Poaceae) extracts against Aedes aegypti (Diptera: Culicidae), Culex quinquefasciatus (Diptera: Culicidae), and Anopheles stephensi (Diptera: Culicidae), and investigates the bioactive chemical compounds responsible for this activity.

Observation of Fascinating Nonlinear Optical Features of Fluorescent Dye in Selected Polar Solvents by Z-Scan and DFT Method.

Third-order nonlinear optical (NLO) properties of Acridine Orange (AO) dye were studied using Z-scan method under low power conditions and DFT method. The dye was completely dissolved in polar solvents, including ethanol, methanol, acetone, and 1-propanol. Significant optical nonlinearity was observed in polar liquids, with methanol showing the largest optical susceptibility for the AO dye.

Enhancing intrafraction position monitoring for prostate radiotherapy on a conventional linear accelerator: an optimization study.

To compare the intrafraction prostate motion monitoring capabilities between intrafraction Cone Beam Computed Tomography (IF-CBCT) and SeedTracker-based real-time monitoring, and to optimize imaging doses in real-time monitoring using the IF-CBCT image acquisition method. Simulations of static and dynamic intrafraction prostate motions were conducted on a phantom using a robotic arm. The study utilized the XVI imaging system of the Elekta linear accelerator for IF-CBCT and SeedTracker-based monitoring during hypofractionation and Stereotactic Body Radiation Therapy (SBRT).

Hyperlipidemia drives tumor growth in a mouse model of obesity-accelerated breast cancer growth.

Obesity is an established risk factor for breast cancer (BC), yet the specific mechanisms driving this association remain unclear. Dysregulated lipid metabolism has emerged as a key factor in cancer cell biology. While obesity is often accompanied by hyperlipidemia, the isolated impact of elevated lipid levels on BC growth has not been experimentally tested.

Sensitivity to change of quadriceps and hamstrings muscle wearable electromyography outcomes during a professional soccer match.

Textile electromyography (EMG) was used to investigate neuromuscular activity during professional soccer matches, providing insights into performance optimization and injury prevention. This explorative study aimed to (1) describe the EMG activity of the quadriceps and hamstrings and (2) identify the metrics most sensitive to changes between the first and second half. Seven players (age: 23.

Unveiling the Therapeutic Promise of Epigenetics in Vascular Cognitive Impairment and Vascular Dementia.

Vascular dementia (VaD) is a progressive neurodegenerative disease characterized by cognitive decline and memory deficits. Despite its significant prevalence and impact, the pathophysiology of VaD remains poorly understood, and current treatments are limited to symptom management. Emerging evidence highlights the importance of lifestyle-associated risk factors in VaD, emphasizing the role of gene-environment interactions, particularly in the realm of epigenetics.

Atypical presentation of tuberculous vasculitis: dual large vessel occlusions leading to malignant ischaemic stroke.

Tuberculosis (TB) is a significant global health challenge, particularly in developing countries. One rare complication of TB is vasculitis, involving inflammation of the blood vessels by TB vasculitis typically results from the haematogenous spread of bacteria to the cerebral vasculature or extension from adjacent tuberculous lesions, such as tuberculomas. The pathogenesis includes direct invasion of vessel walls, leading to inflammation, luminal narrowing, thrombosis and ischaemic brain damage.

Hierarchical Nanoporous Carbons with an Integrated Activation Using 3D Flower-Like ZnO Microspheres and KOH for Flexible EDL Capacitor with a High Operating Potential.

Activated nanoporous carbons are widely used in various applications, where their efficiency is largely determined by their specific surface area and pore structure. Traditional KOH-assisted chemical activation methods primarily produce micropores, limiting the performance of these porous carbons in applications requiring a hierarchical arrangement of micro, meso, and macropores. This study introduces a novel integrated activation strategy using 3D flower-like microsphere (3DFM) ZnO and KOH to synthesize nanoporous carbons from Sesbania Grandiflora side shoots.

DFT and Z-scan Studies for the Determination of Nonlinear Optical Susceptibility and Second Order Hyperpolarizability of Ethidium Bromide Dye in Different Solvents.

Nonlinear optical (NLO) susceptibility of Ethidium Bromide (EB) dye, an excellent NLO material, dissolved in different solvents, including ethanol, methanol, acetone, 1-propanol, DMF, and DMSO is reported. Z-scan tool is used to measure the NLO features of EB dye using open and closed aperture methods. The peak-valley transmittance graph indicating self-defocusing nonlinearity in the nonlinear refractive index of EB dye in different solvents.

Intermolecular Forces in Bioactive Resveratrol Complexes with Alcohols: A Study of Stability and Electronic Structure.

Noncovalent interactions, particularly hydrogen bonding, play a pivotal role in determining the structural stability and functional properties of molecules, including bioactive compounds like resveratrol. This study focuses on the hydrogen-bonding behavior and other noncovalent interactions in gas-phase resveratrol-ethanol (EtOH) and resveratrol-methanol (MtOH) complexes, referred to as System 1 and System 2, respectively. These systems were optimized using the ωB97XD functional and cc-pVDZ basis set, providing a detailed picture of their stability and intermolecular interactions.

Identification and occurrence of microplastics in drinking water bottles and milk packaging consumed by humans daily.

Microplastic (MP) pollution has become a growing concern due to its potential environmental and health impacts. The present study aimed to investigate the presence of MPs in specific brands of drinking water bottle and milk packets. To identify the MPs, researchers employed microscopic techniques, FTIR spectroscopy, and FESEM with EDS.

MnO Tetrahedral with Carbonyldiimidazole Nanoflower Deposition on Laser-Scribed Graphene for Selective Bio-Capture.

Dengue fever, a mosquito-borne viral infection, poses a significant global health challenge, particularly in tropical and subtropical regions. The absence of non-effective vaccines and specific treatments underscores the need for advanced diagnostic tools for early detection and management. This study presents a novel biosensor for detecting dengue virus type 4 (DENV-4) by combining carbonyldiimidazole nanoflower (CDI-NF) with MnO on laser-scribed graphene (LSG).

Energy metabolism coordination for the byproduct-free biosynthesis of 1,3-propanediol in Escherichia coli.

The efficient, byproduct-free production of 1,3-propanediol (1,3-PDO), a valuable chemical widely used in various industries, presents a significant challenge in bio-based manufacturing, due to its reduced nature. In this study, Escherichia coli K12 was engineered to achieve high-yield 1,3-PDO production by optimizing glucose metabolism and utilizing glycerol as a feedstock. Glycolytic flux was rerouted to the NADPH-generating pentose phosphate (PP) pathway, linking NADPH regeneration to 1,3-PDO biosynthesis.

Pharmacophore-based identification and in Silico characterization of microbial metabolites as potential modulators of Wnt signaling pathway in colorectal cancer therapy.

Aberrant activation of the Wnt/β-catenin signaling pathway, primarily driven by APC mutation and AXIN degradation via Tankyrase, contributes significantly to colorectal cancer (CRC) progression and metastasis. The accumulation of β-catenin, resulting from the dysregulated ubiquitination, underscores the need for alternative therapeutic strategies targeting Tankyrase and β-catenin. This present study explores microbial metabolites as a source of novel anti-cancer agents, leveraging their unique bioactivity and structural diversity, often exhibiting superior target specificity and lower toxicity than synthetic drugs.

Pilot scale production of biodiesel from Madhuca indica and comparative techno-economic analysis.

The increasing global energy demand and the depletion of conventional fossil fuel supplies, coupled with greenhouse gas emissions from excessive fossil fuel use, open the door for consideration of renewable energy sources. Among these, biodiesel has arisen as a sustainable and feasible alternative, providing environmental and economic advantages by reducing dependence on finite fossil fuel resources. This study focuses on biodiesel production from Madhuca indica seed oil using three catalysts: HCl, KOH, and dolomite.