Assessment of Knowledge, Attitude, and Practice about "SADE" Among Dentists - A Cross-Sectional Study.

Background: Intellectual and developmental disabilities (IDDs), including autism spectrum disorder (ASD), often lead to sensory challenges and dental anxiety, complicating oral healthcare. Sensory adapted dental environment (SADE) can alleviate anxiety and enhance cooperation during dental procedures, but awareness and implementation among dentists remain limited.

Objective: To assess general dentists' knowledge, attitudes, and practices regarding SADE and identify gaps for targeted educational programs.

Zebra Bodies in the Kidney: Is it a Pathognomonic Finding of Fabry Disease?

Zebra bodies are intralysosomal lamellar inclusion bodies. It is accepted as a specific feature of Fabry disease. However, it has been reported in many hereditary and acquired conditions.

Small or Sharp Edged? Impact of Facets-Controlled Ag{111} Nanoprism on the Gas Sensing Redox Characteristics of WO.

Recent reports that associate the redox characteristics of metal nanostructures (NSs) merely to their particle size are sceptical and need to examine the intrinsic property that dominates their redox properties. Aiming this, the gas sensing redox characteristics of (i) isotropic Ag nanospheres and (ii) the anisotropic Ag{111} nanoprism are examined by decorating them on the WO surface. As revealed by KPFM measurements, the low work function values of Ag{111} (i.

Benefit of Gastro™ Laryngeal Mask Airway® during Total Intravenous Anesthesia for Endoscopic Retrograde Cholangiopancreatography: A Randomized Controlled Study.

Context: Deep level of sedation required during endoscopic retrograde cholangiopancreatography (ERCP) can cause hypoxia in part due to an unsecured airway. This study aims to study the benefits of using the laryngeal mask airway (LMA) Gastro to secure the airway in ERCP.

Aims: To determine the benefit of Gastro LMA for securing airway for ERCP procedure, by recording the incidence of intraprocedural adverse cardiorespiratory events - hypoxia, hypotension, bradycardia, and arrhythmias.

Implementing and validating newborn screening for inborn errors of metabolism in South India: a 2-year observational study at a tertiary care hospital.

Introduction: Newborn screening (NBS) is an essential public health initiative for early diagnosis of inborn errors of metabolism (IEM), where timely intervention can reduce morbidity and mortality. While routine in developed countries, NBS is not widely practised in India. This study aimed to implement NBS programme in a tertiary care hospital in South India and validate predetermined cut-off values tailored to the regional population.

Examining psychological distress among youth in Singapore: Insights from the National Youth Mental Health Study.

Youth is a period of transition associated with immense biological, physical, and social changes, which increases the vulnerability to mental illnesses. The study aimed to establish the prevalence of severe and extremely severe levels of depression and anxiety symptoms among the youths in Singapore and identify the psycho-social factors associated with them. The National Youth Mental Health Study was a cross-sectional epidemiological study of Singapore Residents aged 15-35 years.

Synergistic Interactions of Metals and Quantum Dots: Expanding Frontiers in Fluorescent Sensing.

Fluorescent sensing technologies have emerged as powerful tools in analytical science, offering exceptional sensitivity and selectivity for detecting a wide range of analytes. Among the advanced materials driving these technologies, quantum dots (QDs) and metal nanoparticles (MNPs) stand out due to their unique optical and electronic properties. When combined, these materials exhibit synergistic interactions those significantly enhance the fluorescence signals, enable efficient quenching, and offer tunable optical properties.

A Novel Hepcidin Isoform Jd-Hep from the Sin Croaker Johnius dussumieri (Cuvier, 1830): Recombinant Expression and Insights into the Antibacterial Property and Modes of Action.

Hepcidin is a cysteine-rich antimicrobial peptide that plays an important role in fish immunity. In the current study, we report a novel isoform of hepcidin (Jd-Hep) from Sin croaker, Johnius dussumieri, with an open reading frame (ORF) of 258 nucleotide bases that encodes 85 amino acids containing a signal peptide (24 amino acids), a prodomain (35 amino acids) and a biologically active mature peptide (26 amino acids). Phylogenetic tree analysis showed that J.

A Novel Type I Crustin Isoform from Scylla olivacea and its Antibacterial Potential: Membrane Depolarization, Disruption, and Induction of Reactive Oxygen Species as Modes of Action.

Availability of novel antimicrobial agents is an urgent necessity to combat the growing threat posed by multidrug-resistant bacteria, prompting exploration of marine antimicrobial peptides (AMPs) as potential solutions. Crustacean AMPs are equitably diverse in terms of structure and function, making them consistent templates for novel antimicrobials. From Scylla olivacea gill transcriptome cDNA, a putative Crustin AMP sequence of 333 nucleotides, encoding a 111 amino acid Crustin Type-I isoform was identified.

Comparative Analysis of CBCT vs Intraoral Radiography for Interproximal Caries Detection: A Prospective Diagnostic Study.

Background: Cone-beam computed tomography (CBCT) and intraoral radiography are important imaging modalities for detecting interproximal caries, but their comparative diagnostic accuracy is not well established.

Objective: This prospective clinical study aimed to compare the diagnostic accuracy of CBCT and intraoral radiography in detecting interproximal caries.

Methods: A cohort of 248 adult dental samples with suspected or diagnosed interproximal caries underwent both CBCT and intraoral radiography using standardized protocols.

Role of ALT Perforator Flaps in Head and Neck Reconstruction.

Background: The anterolateral thigh flap is a versatile flap that offers many advantages. These include a long and reliable pedicle that enables a wide arc of rotation, the possibility to harvest a large skin area, raising the flap with underlying fascia and minimal donor site morbidity. The purpose of this study is to show better esthetics and function with the use of ALT perforator flap in head and neck region.

An observational study to find out the relationship between the types of headaches and balance dysfunction by using Fukuda test among young individuals.

Headache disorders are reported by more than 50% of adults during the previous year in India. In addition to their great prevalence, the World Health Organization lists them as amongthe top ten conditions that are the most disabling. The high disability levels among headaches can also occur with several conditions such as vestibular symptoms, and balance alterations.

Crystallographic Analysis of Short Helical Peptides Containing Homologs of Phenylalanine.

Interactions between aromatic side chains of amino acids stabilize the fold and assembly of short peptides. The aromatic π…π and C-H…π interactions have been widely explored in the design of short peptides with specific folding and aggregation patterns. In the present study, we investigated the effect of homologated phenylalanine side chains on the conformation and assembly of peptide helices through X-ray crystallographic structure determination and analysis of five pentapeptides.

A systematic review and meta-analysis of efficacy of vasopressin as a vasoconstrictive and uterotonic drug in laparoscopic myomectomy.

Introduction: Laparoscopic myomectomy is a commonly performed operation with fast recovery and excellent results. However, haemorrhagic nature of the operation mandates us to use variety of vasoconstrictive and uterotonic agents. Amongst which, one of them is vasopressin.

Efficacy of Reso-Pac in Wound Healing After Surgical Removal of Impacted Mandibular Third Molars: A Clinical Study.

Introduction: Extraction wounds in oral cavity are usually self-healing. But, this wound healing is hindered because of factors such as saliva, blood, plaque, food debris which causes post-operative infection and pain due to microbial colonization. Placement of periodontal dressings such as zinc oxide eugenol or methyl methacrylate polymer would provide protection up to some extent despite leaving the site without any dressing, but it has disadvantage of difficulty in removing.

Deciphering Carotenoid and Flowering Pathway Gene Variations in Eastern and Western Carrots ( L.).

Background/objectives: Carrot is a major root vegetable in the owing to its abundant carotenoids, antioxidants, vitamins, and minerals. The modern dark orange western carrot was derived from sequential domestication events from the white-rooted wild form to the pale orange-, purple-, or yellow-rooted eastern carrot. Genetic and molecular studies between eastern and western carrots are meager despite their evolutionary relatedness.

Comparative evaluation of efficacy of guided endodontic technique with and without sleeve for access cavity preparation: An In Vitro study.

Background: Calcific metamorphosis in root canals is common and presents challenges in gaining access. Guided endodontics offers a solution to overcome these difficulties. The PriciGuide® system is a patented guided endodontic technique claiming superior precision compared to sleeve-based guides.

Identification of molecular and cellular infection response biomarkers associated with anthrax infection through comparative analysis of gene expression data.

Bacillus anthracis, a gram-positive bacillus capable of forming spores, causes anthrax in mammals, including humans, and is recognized as a potential biological weapon agent. The diagnosis of anthrax is challenging due to variable symptoms resulting from exposure and infection severity. Despite the availability of a licensed vaccines, their limited long-term efficacy underscores the inadequacy of current human anthrax vaccines, highlighting the urgent need for next-generation alternatives.

Characterisation of islet antibody-negative type 1 diabetes mellitus in Indian children.

Aims: Islet antibody-negative type 1 diabetes mellitus (T1DM) has not been well characterised. We determined the frequency of antibody-negative T1DM and compared it with antibody-positive T1DM in a cohort of north Indian children.

Methods: In a multi-centre, prospective, observational study, 176 Indian children (age 1-18 years) were assessed within 2 weeks of diagnosis of T1DM.

Homoeopathy vs. conventional primary care in children during the first 24 months of life-a pragmatic randomised controlled trial.

Unlabelled: To compare the difference between primary homoeopathic and conventional paediatric care in treating acute illnesses in children in their first 24 months of life. One hundred eight Indian singleton newborns delivered at 37 to 42 weeks gestation were randomised at birth (1:1) to receive either homoeopathic or conventional primary care for any acute illness over the study period. In the homoeopathic group, conventional medical treatment was added when medically indicated.