Statins decrease the risk of hepatocellular carcinoma in metabolic dysfunction-associated steatotic liver disease: A systematic review and meta-analysis.

Background: Metabolic dysfunction-associated steatotic liver disease (MASLD) is a leading cause of chronic liver disease with a significant risk of developing hepatocellular carcinoma (HCC). Recent clinical evidence indicates the potential benefits of statins in cancer chemoprevention and therapeutics. However, it is still unclear if these drugs can lower the specific risk of HCC among patients with MASLD.

Single-cell transcriptomic and cell‑type‑specific regulatory networks in Polima temperature-sensitive cytoplasmic male sterility of Brassica napus L.

Background: Thermosensitive male sterility (TMS) is a heritable agronomic trait influenced by the interaction between genotype and environment. The anthers of plants are composed of various specialized cells, each of which plays different roles in plant reproduction. In rapeseed (Brassica napus L.

Acute pediatric appendicitis in black and white: clinical disparities, impact and future recommendations.

Racial and ethnic disparities have long been studied in the delivery of healthcare. One such avenue is acute pediatric appendicitis, which continues to be an area of significant and continual research. Because of its routine clinical presentation and standardized management, acute pediatric appendicitis serves as an appropriate proxy for studying discrepancies in healthcare.

The pivotal role of arbuscular mycorrhizal fungi in enhancing plant biomass and nutrient availability under drought stress conditions: A global meta-analysis.

Drought is a serious threat to crop productivity and global food security. About 40 % of the worldwide land is considered arid dryland soil because of a lack of rainfall, high solar radiation, and temperature fluctuations. Though rhizobacteria, particularly mycorrhizal fungi (MF), assist plants in coping with drought stress, an intensive quantitative assessment of their effects on plant growth and nutrient availability is still limited.

Monosaccharide-Mediated Glycoxidation of Bovine Serum Albumin and Its Prevention by .

The substantial rise in metabolic illnesses that has occurred in both developed and developing countries over the last three decades has been linked to an increase in sugar-added foods and sweetened beverage intake. The significance of advanced glycation end products (AGEs) in the pathophysiology of metabolic diseases related to modern nutrition is an emerging issue. Spices and herbs can potentially be potent AGE production inhibitors due to their high polyphenol content.

Algerian Prickly Pear Seed By-Products: Fatty Acids Composition, Antioxidant, Enzyme Inhibitory Activities towards Tyrosinase, Urease, α-Amylase, and Cholinesterase, along with the Ability to Protect from Thermal Protein Denaturation.

Prickly pear seed is a source of the most expensive oil in the world, which is rich in vitamins and polyunsaturated fatty acids. Its extraction generates a large quantity of press cake. These two by-products need to be valued.

Molecular prevalence, epidemiology, and phylogenetic analysis of Babesia microti in dogs with a note on its impact on host hematological profile.

Babesia (B.) microti is an intra-erythrocytic protozoan parasite that infects humans as well as domestic and wild animals. Prevalence of B.

Covalent organic frameworks and related innovative materials in chiral separation and recognition.

Chiral recognition and enantioseparation are of paramount importance in various fields, including pharmaceuticals, agrochemicals, and material science. Covalent organic frameworks (COFs) have emerged as promising materials for chiral separation due to their unique structural features and tunable properties. This review provided a comprehensive overview of recent progress in the application of COFs and related innovative materials for chiral separation and recognition.

16S rRNA gene amplicon sequencing data from the gut microbiota of adolescent Afghan refugees.

The gut microbiota residing in the distal ileum and colon is the most complex, diverse, and densest microbial ecosystem in the human body. Despite its known role in human health and disease, gut microbiome diversity and function are rarely explored in vulnerable populations such as refugees. The current study aimed to explore gut microbiota diversity and sources of variation among adolescent Afghan refugees residing in Peshawar, Pakistan.

Elucidating Chiral Resolution of Aromatic Amino Acids Using Glycopeptide Selectors: A Combined Molecular Docking and Chromatographic Study.

An asymmetric synthesis is a favorable approach for obtaining enantiomerically pure substances, but racemic resolution remains an efficient strategy. This study aims to elucidate the chiral resolution of aromatic amino acids and their elution order using glycopeptides as chiral selectors through molecular docking analysis. Chiral separation experiments were conducted using Vancomycin as a chiral additive in the mobile phase (CMPA) at various concentrations, coupled with an achiral amino column as the stationary phase.

Production of Fucoxanthin from Microalgae of Djibouti: Optimization, Correlation with Antioxidant Potential, and Bioinformatics Approaches.

Fucoxanthin, a carotenoid with remarkable antioxidant properties, has considerable potential for high-value biotechnological applications in the pharmaceutical, nutraceutical, and cosmeceutical fields. However, conventional extraction methods of this molecule from microalgae are limited in terms of cost-effectiveness. This study focused on optimizing biomass and fucoxanthin production from , isolated from the coast of Tadjoura (Djibouti), by testing various culture media.

Corrigendum: Methotrexate-conjugated zinc oxide nanoparticles exert substantially improved cytotoxic effect on lung cancer cells by inducing apoptosis.

[This corrects the article DOI: 10.3389/fphar.2023.

Failure of Surgical Aortic Valve Prostheses: An Analysis of Heart Team Decisions and Postoperative Outcomes.

To analyze Heart Team decisions and outcomes following failure of surgical aortic valve replacement (SAVR) prostheses. Patients undergoing re-operations following index SAVR (Redo-SAVR) and those undergoing valve-in-valve transcatheter aortic valve replacement (ViV-TAVR) following SAVR were included in this study. Patients who underwent index SAVR and/or Redo-SAVR for endocarditis were excluded.

Experiences of Multiple Myeloma Patients With Treatment in the Palestinian Practice: A Multicenter Qualitative Study in a Resource-Limited Healthcare System.

Background Multiple myeloma is a crippling cancer that puts a significant strain on patients and their families alike. The long and exhausting treatment journey with the disease is challenging not only for patients but also for healthcare systems. This exploratory study was conducted to look into these patients' experiences with their treatment and explore their recommendations and views to improve the Palestinian healthcare system, which can be viewed as an evolving healthcare system within a resource-limited and developing country.

Surviving the desert's grasp: Decipherment phreatophyte Tamarix aphylla (L.) Karst. Adaptive strategies for arid resilience.

Phreatophytes play an important role in maintaining the ecological services in arid and semi-arid areas. Characterizing the interaction between groundwater and phreatophytes is critical for the land and water management in such areas. Therefore, the identification of key traits related to mitigating desertification in differently adapted T.

Isolation and characterization of chromium-resistant bacteria and their effects on germination, growth, and Cr accumulation in Capsicum annum (L.) under Cr stress.

Chromium (Cr) is a well-known environmental pollutant while less information is available on the role of Cr-resistant bacteria in the alleviation of Cr-stress in chili (Capsicum annum L.) plants. Effect of Cr-resistant bacterial strains on growth and Cr uptake by chili plants was investigated.

Inverse FASN and LDHA correlation drives metabolic resistance in breast cancer.

Background: Breast cancer manifests as a heterogeneous pathology marked by complex metabolic reprogramming essential to satisfy its energy demands. Oncogenic signals boost the metabolism, modifying fatty acid synthesis and glucose use from the onset to progression and therapy resistant-forms. However, the exact contribution of metabolic dependencies during tumor evolution remains unclear.

Gait asymmetrical evaluation of lower limb amputees using wearable inertial sensors.

This study presents an analysis and evaluation of gait asymmetry (GA) based on the temporal gait parameters identified using a portable gait event detection system, placed on the lateral side of the shank of both lower extremities of the participants. Assessment of GA was carried out with seven control subjects (CS), one transfemoral amputee (TFA) and one transtibial amputee (TTA) while walking at different speeds on overground (OG) and treadmill (TM). Gait cycle duration (GCD), stance phase duration (SPD), swing phase duration (SwPD), and the sub-phases of the gait cycle (GC) such as Loading-Response (LR), Foot-Flat (FF), and Push-Off (PO), Swing-1 (SW-1) and Swing-2 (SW-2) were evaluated.

Preliminary Investigation of subsp. : LC-MS/MS Chemical Profiling, In Vitro Evaluation of Antioxidant, Anti-Inflammatory Properties, Cytotoxicity, and In Silico Analysis against COX-2.

The search results offer comprehensive insights into the phenolic compounds, antioxidant, anti-inflammatory, cytotoxic effects, LC-MS/MS analysis, molecular docking, and MD simulation of the identified phenolic compounds in the subsp. extract (AAH). The analysis revealed substantial levels of total phenolic content (TPC), with a measured value of 191 ± 0.

Unraveling the genetic and molecular basis of heat stress in cotton.

Human activities and climate change have resulted in frequent and intense weather fluctuations, leading to diverse abiotic stresses on crops which hampers greatly their metabolic activities. Heat stress, a prevalent abiotic factor, significantly influences cotton plant biological activities resulting in reducing yield and production. We must deepen our understanding of how plants respond to heat stress across various dimensions, encompassing genes, RNAs, proteins, metabolites for effective cotton breeding.

A New Capillary-Channel Agarose Sponge Assembled with Deep Eutectic Solvent Based Magnetic Fluid for Rapid Hemostasis and Prevention of Bacterial Infection.

A new composite sponge assisted by magnetic field-mediated guidance was developed for effective hemostasis. It was based on polydopamine capillary-channel agarose (PDA-CAGA) sponge as matrix; meanwhile, the combination of deep eutectic solvent (DES, choline chloride:glycerol = 1:1, M/M)-dispersed FeO nanoparticles after fabrication by tannic acid (DES-FeO@TA) was applied as hemostatic magnetic fluid. This sponge had oriented and aligned capillary channels realized by a 3D printed pattern, which endowed them with obvious shape memory and liquid absorption performance.