Publications by authors named "Alauddin"

Background: Water, sanitation, hygiene (WSH), nutrition (N), and combined (N+WSH) interventions are often implemented by global health organizations, but WSH interventions may insufficiently reduce pathogen exposure, and nutrition interventions may be modified by environmental enteric dysfunction (EED), a condition of increased intestinal permeability and inflammation. This study investigated the heterogeneity of these treatments' effects based on individual pathogen and EED biomarker status with respect to child linear growth.

Methods: We applied cross-validated targeted maximum likelihood estimation and super learner ensemble machine learning to assess the conditional treatment effects in subgroups defined by biomarker and pathogen status.

View Article and Find Full Text PDF

Mushrooms and fenugreek are widely used to reduce hyperglycemia, and fenugreek is also used as a culinary ingredient to enhance flavor and aroma. This study is aimed at investigating the underlying mechanisms of the hypoglycemic effects of mushrooms and fenugreek in a Type 2 diabetic rat model. Adenosine monophosphate (AMP)-activated protein kinase (AMPK) functions to reduce hyperglycemia through insulin-independent pathways and protects beta-cells.

View Article and Find Full Text PDF

Digital platforms have significantly transformed the labor market, particularly in the gig economy. Despite this issue's growing importance, no systematic literature review has explicitly examined the influence of digital platforms on gig workers. This study fills this gap by conducting a comprehensive review of 18 articles out of 81 published between 2019 and 2023, retrieved from the Scopus and Web of Science databases, using the PRISMA framework.

View Article and Find Full Text PDF

Background: Atherosclerosis is a systemic vascular disease commonly affecting coronary and carotid arteries, particularly in diabetes mellitus (DM). This study assessed the association of DM with significant carotid artery stenosis (CAS) among the coronary artery disease (CAD) population undergoing isolated elective coronary artery bypass graft (CABG) surgery.

Methods: A prospective cross-sectional study evaluated 100 Bangladeshi CAD patients who underwent isolated elective CABG from January 2017 to September 2019.

View Article and Find Full Text PDF

Background Signet ring cell carcinoma (SRCC) is a rare subtype of colorectal cancer with significant variations in clinical characteristics and poor prognosis. However, there is limited data available in Pakistan. Therefore, we analyzed to examine the incidence, clinicopathological features, treatments, and outcomes of SRCC in colorectal cancer cases in Pakistan.

View Article and Find Full Text PDF

The fertility rate of a married woman can be measured by the length of the first birth interval (FBI). This length is influenced by some significant factors. Better knowledge about the factors affecting the birth interval can help in controlling population growth and fertility progress.

View Article and Find Full Text PDF

Background: Type 2 diabetes mellitus (T2DM) leads to cardiac autonomic neuropathy (CAN), affecting blood flow and heart rate regulation eventually causing chronic stable angina (CSA). Percutaneous coronary intervention (PCI) can correct autonomic dysfunctions and improve myocardial perfusion. This study aimed to assess CAN using heart rate variability (HRV) and cardiovascular reflex tests in T2DM patients with CSA before and after PCI.

View Article and Find Full Text PDF

The elderly face malnutrition and dysphagia. 3D printing with high-protein surimi offers an innovative way to customize nutrition and texture of foods for the elderly. This study explored whether tilapia-based surimi ink (TBSI) with Ulva powder (UP, 0-3 %) could improve physicochemical properties and printability as an alternative to traditional pollock-based surimi ink (PBSI).

View Article and Find Full Text PDF
Article Synopsis
  • Uveal melanoma (UM) is a serious cancer with limited treatment options, and this study investigates the effects of imipridones, which activate a protein called CLPP that can indirectly inhibit a harmful energy production process in the cancer cells.
  • Researchers found that imipridones, specifically ONC201 and ONC212, reduce the growth and spread of UM cells in the lab and show promise in decreasing tumor size and increasing survival in animal models.
  • The findings suggest that imipridones could be a new and effective treatment strategy for patients with metastatic uveal melanoma (mUM).
View Article and Find Full Text PDF
Article Synopsis
  • Hemoglobin (Hb) Malay is a common genetic disorder in Malaysia caused by a specific mutation, making it difficult to detect using standard laboratory techniques like capillary electrophoresis and high-performance liquid chromatography.
  • This study analyzed samples from 521 patients suspected of having β thalassemia over five years, successfully identifying 54 cases of Hb Malay with notable differences in blood parameters compared to typical β thalassemia carriers.
  • The researchers recommend a new cutoff value for hemoglobin A (HbA) of ≤4.6% to help confirm Hb Malay carrier status, noting that those with Hb Malay may have a different clinical presentation than classical β° thalassemia carriers.
View Article and Find Full Text PDF

Thalassemia is one of the most prevalent monogenic disorders in low- and middle-income countries (LMICs). There are an estimated 270 million carriers of hemoglobinopathies (abnormal hemoglobins and/or thalassemia) worldwide, necessitating global methods and solutions for effective and optimal therapy. LMICs are disproportionately impacted by thalassemia, and due to disparities in genomics awareness and diagnostic resources, certain LMICs lag behind high-income countries (HICs).

View Article and Find Full Text PDF

Coronary artery bypass grafting (CABG) utilizing saphenous vein grafts (SVGs) stands as a fundamental approach to surgically treating coronary artery disease. However, the long-term success of CABG is often compromised by the development of intimal hyperplasia (IH) and subsequent graft failure. Understanding the mechanisms underlying this pathophysiology is crucial for improving graft patency and patient outcomes.

View Article and Find Full Text PDF

Introduction The risk of sudden death in patients with chronic coronary syndrome (CCS) is increased by unbalanced cardiovascular autonomic function. Since myocardial ischemia appears to be the cause of this condition of autonomic dysregulation, treating this condition should improve and correct the autonomic functions. Improving myocardial perfusion by PCI might have beneficial effects on the recovery of autonomic balance in ischemia-triggered autonomic dysregulation.

View Article and Find Full Text PDF

Statement Of Problem: Current 3-dimensionally (3D) printed denture bases have inadequate strength and durability for long-term use, and milled denture bases generate excessive waste. Addressing these limitations is crucial to advancing prosthetic dentistry, ensuring improved patient outcomes and promoting environmental responsibility.

Purpose: The purpose of this in vitro study was to incorporate microparticles into a commercially available 3D printed denture base resin and compare its mechanical and biological properties with the conventional polymethyl methacrylate (PMMA) denture base material.

View Article and Find Full Text PDF

Background: Ehlers-Danlos syndrome (EDS) may be linked to dysfunction in the autonomic nervous system, affecting collagen production and processing. These collagen abnormalities lead to a condition called dysautonomia. Findings underscore the need for further investigation into autonomic nervous system function in EDS which involves larger studies to strengthen the evidence of non-invasive screening tools like cardiovascular reflex tests.

View Article and Find Full Text PDF

Background: Reporting and analysis of adverse events (AE) is associated with improved health system learning, quality outcomes, and patient safety. Manual text analysis is time-consuming, costly, and prone to human errors. We aimed to demonstrate the feasibility of novel machine learning and natural language processing (NLP) approaches for early predictions of adverse events and provide input to direct quality improvement and patient safety initiatives.

View Article and Find Full Text PDF

Background: Water, sanitation, hygiene (WSH), nutrition (N), and combined (N+WSH) interventions are often implemented by global health organizations, but WSH interventions may insufficiently reduce pathogen exposure, and nutrition interventions may be modified by environmental enteric dysfunction (EED), a condition of increased intestinal permeability and inflammation. This study investigated the heterogeneity of these treatments' effects based on individual pathogen and EED biomarker status with respect to child linear growth.

Methods: We applied cross-validated targeted maximum likelihood estimation and super learner ensemble machine learning to assess the conditional treatment effects in subgroups defined by biomarker and pathogen status.

View Article and Find Full Text PDF

Rice bran (RB) and rice bran oil (RBO) are exploring as prominent food component worldwide and their compositional variation is being varied among the world due to regional and production process. In this study, Fermented Rice Bran (FRB) was produced by employing edible gram-positive bacteria (Lactobacillus acidophilus, Lactobacillus bulgaricus and Bifidobacterium bifidum) at 125×10 spore g of rice bran, and investigated to evaluate nutritional quality. The Crude Rice Bran Oil (CRBO) was extracted from RB and its quality was also investigated compared to market available rice bran oil (MRBO) in Bangladesh.

View Article and Find Full Text PDF

Background: A considerable link between personality types and cardiovascular diseases (CVDs) has been seen. Autonomic responses in both type A and type B personality individuals were found to be influenced by their personality traits. The study suggests further research on cardiac autonomic functions in larger sample sizes and the use of non-invasive screening techniques like cardiovascular reflex tests to stratify participants' risk of future illness.

View Article and Find Full Text PDF

Enzyme-Treated Soymilk (ETS) was produced from Commercial Soymilk (CSM) with the treatment of proteinase PROTIN SD-NY10 (Bacillus amyloliquefaciens). Previously, we have isolated novel peptides from ETS but data related to isolated-peptides are scant. In this study, bio-informatics and in vivo analysis of isolated-peptides showed strong binding affinity to the active site of the Angiotensin Converting Enzyme (ACE).

View Article and Find Full Text PDF

Purpose: Uveal melanoma (UM) is a highly aggressive disease with very few treatment options. We previously demonstrated that mUM is characterized by high oxidative phosphorylation (OXPHOS). Here we tested the anti-tumor, signaling and metabolic effects of imipridones, CLPP activators which reduce OXPHOS indirectly and have demonstrated safety in patients.

View Article and Find Full Text PDF
Article Synopsis
  • AI has shown high accuracy in detecting diabetic retinopathy (DR) in children and young adults with diabetes, highlighting the need for more research in this area.
  • A study conducted on 1,274 participants aged 3-26 found that 19.4% had any DR, with 2.35% classified as referable DR by AI.
  • The performance metrics indicated that AI had strong sensitivity and specificity rates, especially in younger children with less diabetes duration, suggesting it could be a valuable resource in low-resource settings for screening purposes.
View Article and Find Full Text PDF
Article Synopsis
  • G6PD deficiency is an X-linked genetic disorder that poses a significant health risk, especially in malaria-endemic regions, where individuals can suffer from severe anemia when treated with certain antimalarial drugs.
  • Current G6PD screening tests are often complicated and can misclassify cases, particularly in women with intermediate activity levels, but new quantitative point-of-care (POC) tests offer a better screening option to prevent anemia.
  • A review of studies on two POC tests, the CareStart Biosensor and the STANDARD G6PD kit, found them to be effective with high sensitivity, specificity, and accuracy, supporting their use in malaria treatment settings in regions with high G6PD deficiency.
View Article and Find Full Text PDF

Programmed death ligand 1 (PD-L1) is a type 1 transmembrane immunosuppressive protein that is expressed on a wide range of cell types, including cancer cells. Anti-PD-L1 antibodies have revolutionized cancer therapy and have led to improved outcomes for subsets of cancer patients, including triple-negative breast cancer (TNBC) patients. As a result, PET imaging of PD-L1 protein expression in cancer patients has been explored for noninvasive detection of PD-L1 expressing tumors as well as monitoring response to anti-PD-L1 immune checkpoint therapy.

View Article and Find Full Text PDF

A PHP Error was encountered

Severity: Warning

Message: fopen(/var/lib/php/sessions/ci_sessiont6agjuk965l4ocqqmhqa9vojegiuh20q): Failed to open stream: No space left on device

Filename: drivers/Session_files_driver.php

Line Number: 177

Backtrace:

File: /var/www/html/index.php
Line: 316
Function: require_once

A PHP Error was encountered

Severity: Warning

Message: session_start(): Failed to read session data: user (path: /var/lib/php/sessions)

Filename: Session/Session.php

Line Number: 137

Backtrace:

File: /var/www/html/index.php
Line: 316
Function: require_once