Publications by authors named "Akshay"

In the present work, we propose an experimental setup to investigate the effect of atmospheric turbulence on user-defined beams. The user-defined beams were formed by writing reconfigurable patterns on a spatial light modulator, allowing the impact of atmospheric turbulence to be investigated simultaneously and in real time. The programmable controllability provides several flexibilities to the system, such as the ability to create different beam types simultaneously, control the separation between different beams, compensate for aberrations, and easily switch between different beam types.

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Hybrid supercapacitors such as Lithium-ion capacitors (LICs) are one of the most modern energy storage devices of great research interest. The hybridization of the battery-type anode with the capacitive-type cathode brings out the synergic effect of enhanced energy density, power capability, long cycle life, and wide operating temperature. Herein, we introduce a simultaneous alloying-intercalation process from the recovered graphite: silicon monoxide (RG: SiO) composite as a negative electrode for the LIC applications with the activated carbon (AC) as a counter electrode.

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Unlabelled: Sedentary lifestyles lead to postural deformities, Lower Back Pain(LBP) and Colorectal cancer(CRC). Practicing Yoga attains definite strength in muscles by activating muscle fibers. The Yoga poses analyzed are often used in strengthening and stability programs for the abdomen and back muscles.

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  • Induced pluripotent stem cells (iPSCs) are being used to create advanced models for studying diseases and testing drugs, especially in lung research.
  • By differentiating iPSCs into lung organoids in a controlled microenvironment that adjusts oxygen and pressure, researchers were able to mimic the structure and function of real lung tissue.
  • The developed lung organoids exhibited complex cellular architecture and increased gene/protein expression related to lung development, making them valuable for studying lung biology in both healthy and diseased states.
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  • India faces a serious health crisis, with 315 million adults dealing with hypertension and 100 million with diabetes, prompting the launch of the CoCo-HD program in Kerala and Tamil Nadu to implement large-scale lifestyle interventions.
  • The program aims to evaluate peer support and community mobilization as strategies to enhance diabetes and hypertension management while assessing factors influencing scalability and the economic impact of the intervention.
  • The CoCo-HD program will involve collaborative approaches, train community health workers, and measure outcomes using established evaluation frameworks to ensure effective implementation and improved health outcomes.
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  • A rare case of hidradenoma in the pinna (outer ear) is reported, as such occurrences are not commonly found in medical literature.
  • The patient, a 45-year-old female, had a lump behind her right ear for 6 months, with no pain, only a serous discharge.
  • After confirming the diagnosis through Fine Needle Aspiration Cytology (FNAC) and performing wide surgical excision, subsequent histopathology confirmed the diagnosis, and the patient is currently free of recurrence.
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Aim: Colistin serves as the drug of last resort for combating numerous multidrug-resistant (MDR) Gram-negative infections. Its efficacy is hampered by the prevalent issue of colistin resistance, which severely limits treatment options for critically ill patients. Identifying resistance genes is crucial for controlling resistance spread, with horizontal gene transfer being the primary mechanism among bacteria.

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  • Aeromonas hydrophila is a harmful pathogen in aquaculture, causing economic losses, but recent advancements in nanotechnology could help create effective vaccines.
  • This study examined a vaccine using nanoparticle-loaded outer membrane protein A (OmpA) from A. hydrophila, showing good size and encapsulation efficiency with promising results in zebrafish models.
  • The oral administration of the nanoparticle vaccine led to a 77.7% survival rate in infected zebrafish, suggesting it stimulates a strong immune response and offers significant protection against the pathogen.
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Background The surge in the twin burden of malnutrition - undernutrition and overweight/obesity - poses a severe threat worldwide including India. The adult group, primarily considered as an economic pillar of the society, suffered significant health problems, yet their nutritional issues are often neglected. Screening of nutritional status through anthropometric measurements is widely accepted.

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In the present investigation, we present the comparison of the structural, magnetic, magnetocaloric and magnetoresistance behavior of solid state and sol-gel derived LaSrMnO. X-ray diffraction together with Rietveld refinement confirms the rhombohedral structure of the synthesised samples with the 3̄ space group. The ferromagnetic-to-paramagnetic transition temperature decreases from 360 K to 346 K for the nanocrystalline sample.

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Aims: Acinetobacter baumannii is a nosocomial pathogen known to be multidrug-resistant (MDR), especially to drugs of the carbapenem class. Several factors contribute to resistance, including efflux pumps, β-lactamases, alteration of target sites, and permeability defects. In addition, outer membrane proteins (OMPs), like porins are involved in the passage of antibiotics, and their alteration could lead to resistance development.

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Electric vehicles (EVs) are the future of the automobile industry, as they produce zero emissions and address environmental and health concerns caused by traditional fuel-poared vehicles. As more people shift towards EVs, the demand for power consumption forecasting is increasing to manage the charging stations effectively. Predicting power consumption can help optimize operations, prevent grid overloading, and power outages, and assist companies in estimating the number of charging stations required to meet demand.

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Lower urinary tract dysfunction (LUTD) presents a global health challenge with symptoms impacting a substantial percentage of the population. The absence of reliable biomarkers complicates the accurate classification of LUTD subtypes with shared symptoms such as non-ulcerative Bladder Pain Syndrome (BPS) and overactive bladder caused by bladder outlet obstruction with Detrusor Overactivity (DO). This study introduces a machine learning (ML)-based approach for the identification of mRNA signatures specific to non-ulcerative BPS.

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Background: Benign prostatic hyperplasia in elderly males often causes bladder outlet obstruction termed benign prostatic obstruction (BPO). BPO induces lower urinary tract symptoms and quantifiable urodynamic alterations in bladder function. When conservative medical treatments are exhausted, surgical interventions like transurethral resection of the prostate (TURP) are employed for bladder outlet de-obstruction.

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The gut-cardiac axis represents an emerging area of research focusing on the relationship between gut health and cardiovascular function. This narrative review examines the Gut-Cardiac Axis, emphasizing its emerging role in cardiovascular health and disease management. Traditionally viewed as a component of the digestive system, the gut is now recognized for its significant influence on cardiac health.

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Lower urinary tract dysfunction (LUTD) presents a global health challenge with symptoms impacting a substantial percentage of the population. The absence of reliable biomarkers complicates the accurate classification of LUTD subtypes with shared symptoms such as non-ulcerative Bladder Pain Syndrome (BPS) and overactive bladder caused by bladder outlet obstruction with Detrusor Overactivity (DO). This study introduces a machine learning (ML)-based approach for the identification of mRNA signatures specific to non-ulcerative BPS.

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Background: Machine learning (ML) has emerged as a vital asset for researchers to analyze and extract valuable information from complex datasets. However, developing an effective and robust ML pipeline can present a real challenge, demanding considerable time and effort, thereby impeding research progress. Existing tools in this landscape require a profound understanding of ML principles and programming skills.

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  • * The study involved 100 newly diagnosed type 2 diabetes patients and 100 matched controls, measuring various blood sugar and insulin levels.
  • * Results showed that neuregulin-4 levels were significantly lower in diabetes patients compared to controls, with negative correlations to blood sugar and insulin resistance indicators.
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  • Evaluating machine learning models effectively requires multiple metrics, but comparing them can be time-consuming and biased.
  • The Machine Learning Cumulative Performance Score (MLcps) simplifies this by combining multiple evaluation metrics into one score, allowing for a clearer assessment of a model's performance.
  • Researchers can use MLcps to easily evaluate and compare models without the need for individual metric analysis, making the process faster and more efficient.
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Lithium-ion hybrid capacitors (LICs) have become promising electrochemical energy storage systems that overcome the limitations of lithium-ion batteries and electrical double-layer capacitors. The asymmetric combination of these devices enhances the overall electrochemical performance by delivering simultaneous energy and power capabilities. Lithium titanate (LiTiO, LTO), a spinel zero-strain material, has been studied extensively as an anode material for LIC applications because of its high-rate capability, negligible volume change, and enhanced cycling performance.

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  • Despite significant advances in antibiotic treatment, drug-resistant pathogens continue to cause high mortality and economic losses worldwide, primarily due to multi-drug and extensive drug resistance.
  • The interplay between efflux systems and outer membrane proteins (OMPs) is crucial for understanding the mechanisms behind this drug resistance.
  • Developing targeted strategies and policies at various levels is essential to combat the rise of drug resistance effectively.
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Background: In recent years, 3-dimensional (3D) spheroid models have become increasingly popular in scientific research as they provide a more physiologically relevant microenvironment that mimics in vivo conditions. The use of 3D spheroid assays has proven to be advantageous as it offers a better understanding of the cellular behavior, drug efficacy, and toxicity as compared to traditional 2-dimensional cell culture methods. However, the use of 3D spheroid assays is impeded by the absence of automated and user-friendly tools for spheroid image analysis, which adversely affects the reproducibility and throughput of these assays.

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Context: Endodontic retreatment is the first line of treatment in cases of failed primary endodontic treatment. Although associated with challenges such as incomplete removal of obturating material, increased clinical time, and extrusion of apical debris, endodontic retreatment still has considerable success rate in the general population.

Aims: The aim of this study was to evaluate and compare the efficacy of TruNatomy, ProTaper retreatment, and RaCe file systems to remove the obturating material, time taken to remove the obturating material, and apical extrusion of debris using cone-beam computed tomography (CBCT).

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  • The study focused on evaluating the use of non-vascularized fibular autografts as medial support in patients with unstable proximal humerus fractures treated with a locking plate.
  • A total of 18 patients aged 50-70 were monitored for at least two years, showing successful radiological union and favorable functional outcomes, including a good range of shoulder motion.
  • No cases of varus collapse or avascular necrosis were reported, indicating that this surgical approach could be an effective option for managing unstable proximal humerus fractures.
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