Publications by authors named "Akio Ido"
[Clinical practice of the IPMN on the basis of the guideline].
Nihon Shokakibyo Gakkai Zasshi
January 2025
Background: Intra-oesophageal acid stimulation increases masseter muscle activity. However, the infusion speeds used in previous studies are significantly slow, with minimal acid volume (30 mL over 30 min). Additionally, it is unclear how masseter muscle activity, symptoms of discomfort, stress levels and saliva quantity change over time.
View Article and Find Full Text PDFAim: The incidence of and factors involved in gastroesophageal varix-related events in hepatitis C virus-related cirrhosis patients, including decompensated cirrhosis, after direct-acting antiviral therapy are unclear.
Methods: We conducted a multicenter study using prospective data from 478 hepatitis C virus-related cirrhosis patients treated with direct-acting antiviral therapy from February 2019 to December 2021 at 33 Japanese hospitals. Gastroesophageal varices were classified as F1 (small-caliber), F2 (moderately enlarged), or F3 (markedly enlarged) according to the Japanese criteria.
Background: Esophageal mucosal resection for superficial esophageal cancer can lead to postoperative esophageal stricture, with current preventive measures being insufficient. Sprayable wound dressings containing hydrophobized microparticles exhibit strong adhesion. This study aimed to investigate the preventive effects of hydrophobized microparticles on esophageal stenosis following endoscopic submucosal dissection.
View Article and Find Full Text PDFObjectives: Although delayed bleeding after endoscopic procedures has become a problem, currently, there are no appropriate animal models to validate methods for preventing it. This study aimed to establish an animal model of delayed bleeding after endoscopic procedures of the gastrointestinal tract.
Methods: Activated coagulation time (ACT) was measured using blood samples drawn from a catheter inserted into the external jugular vein of swine ( = 7; age, 6 months; mean weight, 13.
Article Synopsis
- Resistance-associated substitutions (RASs) in hepatitis C virus (HCV) can significantly reduce the effectiveness of direct-acting antivirals (DAAs), particularly in patients experiencing treatment failure.
- In a study using a subgenomic replicon system, specific RASs were found to have extremely high levels of resistance to several DAAs, showcasing the varying degrees of resistance among different mutations.
- The research indicates that combining pibrentasvir with sofosbuvir may effectively treat HCV infections with these resistance mutations, potentially leading to successful eradication.
Purpose: This study aimed to investigate the impact of hepatocyte growth factor (HGF) on colonic morphology and gut microbiota in a rat model of short bowel syndrome (SBS).
Methods: SD rats underwent jugular vein catheterization for total parenteral nutrition (TPN) and 90% small bowel resection [TPN + SBS (control group) or TPN + SBS + intravenous HGF (0.3 mg/kg/day, HGF group)].
Article Synopsis
- Recent advancements in treatments for hepatocellular carcinoma (HCC) have improved patient survival, but these therapies are expensive, creating a financial burden on patients and society.
- A study analyzed first-line systemic treatments for advanced HCC in Japan, focusing on the number of patients receiving different treatments and their associated monthly costs from July 2021 to June 2022.
- The study found that 82.2% of patients received high-cost regimens, with atezolizumab plus bevacizumab being the most common and expensive treatment at 1,176,284 JPY per month.
Nanoliposomal irinotecan with fluorouracil and folinic acid (NFF) is a standard regimen after gemcitabine-based therapy for patients with unresectable or recurrent pancreatic cancer. However, there are limited clinical data on its efficacy and safety in the real-world. We therefore initiated a retrospective and prospective observational study (NAPOLEON-2).
View Article and Find Full Text PDF: We aimed to determine the trends over time and current status of early -uninfected gastric cancer (HpUIGC) treatment in a region with an aging population. : This retrospective, multi-center observational study was conducted at seven major general hospitals in Kagoshima Prefecture. From January 2009 to July 2022, 2091 patients who received endoscopic resection (ER) for early gastric cancer (EGC) were retrospectively enrolled, of which 35 were identified as early HpUIGC cases.
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- A study in Japan involving 1,364 patients with autoimmune pancreatitis (AIP) aimed to assess the long-term risks of malignancies, particularly pancreatic cancer (PC).
- The results indicated that AIP patients had a higher risk of developing malignancies, especially PC, with the risk increasing shortly after diagnosis and persisting over time.
- Maintenance steroid therapy was found to lower cancer risk and enhance overall survival, despite its negative effects on conditions like diabetes and osteoporosis.
Background: We evaluated the effect of recombinant human hepatocyte growth factor (rh-HGF) on intestinal adaptation in a rat model of short-bowel syndrome (SBS).
Methods: Sprague-Dawley rats underwent jugular vein catheterization for continuous total parenteral nutrition (TPN) and 90 % small bowel resection. The animals were divided into 3 groups: TPN/SBS (control group, n = 7), TPN/SBS/intravenous recombinant human hepatocyte growth factor (HGF) (0.
A 77-year-old male patient underwent esophagogastroduodenoscopy at his family doctor, and an easily hemorrhagic depressed lesion was noted near the anterior wall of the gastric antrum. A biopsy revealed moderately differentiated tubular adenocarcinoma > poorly differentiated adenocarcinoma, and the patient was referred to our department for further examination. A 15-mm 0-IIc lesion is seen near the anterior wall of the gastric antrum and narrow band imaging magnifying endoscopy revealed obscured glandular duct structures and corkscrew pattern vascular structures.
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- This study aimed to explore how autophagy is linked with apoptosis in liver damage within a rat model that simulates short bowel syndrome (SBS).
- Rats were divided into two groups to receive different treatments: one group received standard care (Control) and the other received hepatocyte growth factor (HGF).
- Results showed that HGF treatment reduced liver inflammation and injury markers while possibly enhancing cell survival, indicating a complex role in liver health that needs further investigation.
Article Synopsis
- GPNMB, a protein expressed in macrophages, is linked to liver recovery following acute liver injury (ALI) in mice and is studied for its role in human ALI and acute liver failure (ALF).
- The study assessed serum GPNMB levels over time in 56 ALI/ALF patients, revealing higher GPNMB levels associated with severe conditions like hepatic encephalopathy and adverse outcomes such as liver transplantation or death.
- Findings suggest that elevated serum and liver GPNMB correlate with liver injury severity and prognosis, with GPNMB-positive macrophages presenting an immunosuppressive M2c phenotype, highlighting its potential as a prognostic marker for ALI and ALF patients.
Article Synopsis
- The video demonstrates Endoscopic Submucosal Dissection (ESD) techniques for treating gastric cancer in patients with severe scarring.
- It showcases the use of the PCM (Polypectomy Clip Method) for effective removal and management of the cancerous tissue.
- Additionally, the S-O clip is highlighted as a tool that aids in achieving better outcomes during the procedure.
Article Synopsis
- The study analyzed 206 patients with decompensated cirrhosis due to hepatitis C treated with direct-acting antivirals (DAA) from February 2019 to December 2021 in Japan.
- Patients were mostly older, with 76% classified as Child-Pugh class B (CP-B), and the survival rates were promising, with high 2- and 3-year liver transplantation (LT)-free survival rates.
- The research found that liver function, assessed at 12 weeks after DAA treatment, was a crucial predictor of prognosis, rather than the baseline liver function at the start of treatment.
Background: The rate of metachronous recurrence after endoscopic submucosal dissection for early-stage esophageal squamous cell carcinoma and hypopharynx squamous cell carcinoma is as high (10-15%). The acetaldehyde breath test may detect acetaldehyde dehydrogenase 2 gene polymorphisms. Therefore, we evaluated its usefulness in assessing metachronous recurrence in patients with esophageal squamous cell carcinoma and hypopharynx squamous cell carcinoma.
View Article and Find Full Text PDFExtrahepatic portal vein aneurysm (PVA) is a rare condition in which the extrahepatic portal vein is partially dilated into a sac-like or spindle-like shape. Usually, patients are followed, but surgery is considered in cases of rupture, thrombus, or enlargement. We report a case of thrombus formation in an extrahepatic portal vein aneurysm following trauma that resulted in regression of the aneurysm and extrahepatic portal vein occlusion.
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- * A total of 33 patients were included, with 96.8% yielding DNA samples; NGS success rates were 76.7% for FFPE and frozen samples, while LBC showed a slight edge at 83.3%.
- * Overall, the research indicates that LBC is a promising and cost-effective option for molecular testing in pancreatic cancer compared to traditional methods like FFPE and frozen samples.
Chronic kidney disease (CKD) is a risk factor for end-stage renal disease and contributes to increased risk of cardiovascular disease morbidity and mortality. We aimed to develop a risk prediction score and equation for future CKD using health checkup data. This study included 58,423 Japanese participants aged 30-69 years, who were randomly assigned to derivation and validation cohorts at a ratio of 2:1.
View Article and Find Full Text PDFA 68-year-old woman with ascending colon cancer was the patient (cT4bN2M1a [LYM] cStage IVA, BRAF V600E mutation-positive, and MSI-high). She was given modified FOLFOXIRI as first-line therapy but did not respond. The infiltration of the primary lesion in the abdominal wall was alleviated, allowing conversion surgery to be performed.
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- An 87-year-old man was admitted to the hospital with black stool, anemia, and multiple gastric ulcers, and his condition worsened, leading to a diagnosis of acute liver failure (ALF) with hepatic coma.
- Laboratory tests indicated high liver enzyme levels, elevated inflammation markers, and signs of a potential hematologic tumor.
- Despite efforts for treatment, the man passed away three days later; autopsy revealed aggressive natural killer-cell leukemia (ANKL) as the underlying cause.
Hepatocyte growth factor (HGF) serves key roles in cell motility, proliferation and immunoregulatory functions. However, the effect of HGF on macrophages is unclear. The present study aimed to elucidate the effect of HGF on the phenotypic alterations of intestinal lamina propria mononuclear cells (LPMCs).
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