Psoriasis is a chronic condition, and switching treatment options is common for patients who don't respond well to initial therapies, particularly for those with more severe disease.
Patients who switch biologics may develop anti-drug antibodies, which could reduce the effectiveness of future treatments.
An observational study of five patients with severe plaque psoriasis showed that after switching from brodalumab to adalimumab and then back to brodalumab, patients experienced a significant return of efficacy, improving both skin and joint symptoms.