Publications by authors named "Ηαnnah E Wong"
Article Synopsis
- Streptococcus pneumoniae is a major cause of pneumonia in humans, producing virulence factors like pneumolysin and autolysin that lead to severe inflammation.
- Researchers identified a strain with a genetic mutation (Δ(lytA'-ply')593) found in horses that lacks the usual virulence functions, resulting in less severe disease in these animals compared to humans.
- In experiments, this mutant strain caused lower levels of pro-inflammatory cytokines in immune cells and mice models, suggesting it has a reduced ability to provoke inflammation and severe disease in non-human hosts.
