Publications by authors named "İsmail Zengin"
Blood is a vital reservoir housing numerous disease-related metabolites and cellular components. Thus, it is also of interest for cancer diagnosis. Surface-enhanced Raman spectroscopy (SERS) is widely used for molecular detection due to its very high sensitivity and multiplexing properties.
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- The study focused on the serum levels of matrix metalloproteinases (MMPs) and tissue inhibitors of metalloproteinases (TIMPs) in breast cancer patients to assess their predictive value for treatment response, especially after neoadjuvant chemotherapy.
- A total of 96 breast cancer patients and 35 healthy individuals were evaluated, measuring MMP-2, MMP-9, TIMP-1, and TIMP-2 levels using ELISA.
- Results indicated higher levels of MMP-9 and TIMP-2 in breast cancer patients, which may help gauge tumor stage and chemotherapy response, while MMP-2 levels were lower at diagnosis and correlated negatively with tumor size and metastasis post-treatment.
Article Synopsis
- Breast cancer is rare in men and tends to increase with age, similar to women, but is less studied in male patients with neurofibromatosis type 1.
- Neurofibromatosis type 1, an autosomal dominant genetic disorder, raises the risk of various cancers, yet breast cancer's characteristics differ between males and females, with males showing positive estrogen and progesterone receptors and negative HER2.
- There is a need for better evaluation and follow-up recommendations for breast cancer in male neurofibromatosis patients, as current guidelines are lacking.
The Karaman score: A new diagnostic score for acute appendicitis.
Ulus Travma Acil Cerrahi Derg
November 2018
Background: The Karaman score is a novel diagnostic scoring system consisting of 6 parameters. The aim of the present study was to assess the diagnostic performance of the Karaman score in comparison with the Alvarado score.
Methods: A total of 200 patients who underwent an appendectomy were enrolled in the study (research registry number: 2290).
Objectives: Although non-traumatic Small Bowel Perforations (SBPs) are rare, they have high rates of morbidity and mortality in case of late presentation. Aetiological factors vary across different geographical regions. In this paper, SBPs caused by anything other than trauma and other well-known causes are presented and the current literature is reviewed.
View Article and Find Full Text PDFSitus inversus totalis is a rare congenital abnormality with mirror symmetry of mediastinal and abdominal organs. Immune thrombocytopenic purpura is an autoimmune disease with destruction of thrombocytes. This paper is presentation of surgical approach to a case with coexistence of these two conditions.
View Article and Find Full Text PDFRetroanastomotic hernia after Moynihan's gastroenterostomy.
World J Gastrointest Surg
September 2014
Retroanastomotic hernias after gastroenterostomies-either antecolic or retrocolic-are extremely rare but are associated with high mortality rates due to delayed identification which precludes immediate surgical reduction. In this report, we present a 77-year-old man with retroanastomotic herniation of the efferent loop segments that occurred 14 years after a Moynihan's gastroenterostomy.
View Article and Find Full Text PDFSliding hernias are those in which part of the sac wall is formed by a retroperitoneal organ and/or its mesentery protruding outside the abdominal wall cavity. The hernia sac may contain jejunum, ileum, vermiform appendix, Meckel's diverticulum, stomach, ovary, fallopian tube or urinary bladder. Our report features an adult case with cryptorchidism in which testis and spermatic cord constitute a component of the indirect inguinal hernia sac.
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