Importance of mediastinal granulomatous/sarcoid-like lymphadenopathy in extrathoracic malignancies.

Background: In patients with extrathoracic malignancies (ETM), granulomatous lymph adenopathy called sarcoid-like reactions (SLR) can be seen in the regional or draining lymph nodes. We hypothesized that SLR may be a sign of imminent metastasis and investigated the clinical course and rate of recurrence in patients with ETM and granulomatous mediastinal lymphadenopathy (MLN).

Methods: In this retrospective observational study, we reviewed the medical files of patients with known ETM and who underwent EBUS-TBNA for initial staging or detection of recurrence from 2011 to 2023.

Evaluation of lung cancer biomarkers profile for the decision of targeted therapy in EBUS-TBNA cytological samples.

Background: Guidelines recommend performing biomarker tests for epidermal growth factor receptor (EGFR), anaplastic lymphoma kinase (ALK), BRAF and ROS proto-oncogene-1(ROS1) genes and protein expression of programmed death ligand-1(PD-L1) in patients with non-small lung cell carcinoma (NSCLC). Studies reported that endobronchial ultrasound-transbronchial needle aspiration (EBUS-TBNA) can provide sufficient material for cancer biomarker analyses, but there are still concerns about the subject.

Aim: The purpose of the study was to assess the adequacy of EBUS-TBNA for testing lung cancer biomarkers.

Is endobronchial ultrasound-transbronchial needle aspiration (EBUS-TBNA) reliable and safe procedure in geriatric patients?

Background: Even though studies have indicated the usefulness and safety of endobronchial ultrasound-transbronchial needle aspiration (EBUS-TBNA), elderly patient data are limited due to the small sample sizes.

Aim: We aimed to evaluate usage and safety of EBUS-TBNA in elderly population.

Methods: This single-center retrospective study was conducted with patients who underwent an EBUS-TBNA procedure between September 2011 and December 2019.

Using RV/LV ratio and cardiac biomarkers to define the risk of mortality from pulmonary embolism.

Introduction: Acute pulmonary thromboembolism (PTE) is a common cause of cardiovascular mortality. Right ventricular (RV) dysfunction is the most important cause of mortality. Computed Tomography Pulmonary Angiography (CTPA) can detect right ventricular enlargement which is an indicator of RV dysfunction at the time of diagnosis.

Regional distribution of genetic mutation in lung cancer in Turkey (REDIGMA).

Introduction: The results of standard chemotherapy in lung cancer are not very satisfactory, so it is important to identify genetic mutations that provide targeted therapies. Recent reports have suggested influences of racial difference on the frequency of mutation in lung cancer. We aimed to determine the frequency and regional distribution of genetic mutations of non-small cell lung cancer (NSCLC) in Turkey.

High serum YKL-40 level is associated with poor prognosis in patients with lung cancer.

Introduction: YKL-40 is a glycoprotein that plays role in inflammation and malignant processes. High serum YKL-40 levels are associated with short survive in cancer and chronic obstructive pulmonary disease (COPD) is another reason to increase its' level. However, limited knowledges are known in YKL-40 along with lung cancer and COPD.

Frequency of vitamin K oxidoreductase complex subunit-1 (VKORC1) polymorphisms and warfarin dose management in patients with venous thromboembolism.

Warfarin works by inhibiting VKORC1, so polymorphisms of this gene modify the required drug dose. The aim of this study is to examine the relation between therapeutic weekly dose of warfarin and C1173T/G1639A polymorphism of VKORC1 in patients with VTE. Seventy-five patients with VTE were enrolled.

Is oxygen saturation variable of simplified pulmonary embolism severity index reliable for identification of patients, suitable for outpatient treatment.

Introduction: The pulmonary embolism severity index (PESI) or simplified version (sPESI) are widely validated risk scores for the identification of eligible patients for outpatient treatment. Saturation is one of these criteria. For this metric, saturation of 90% or greater is assigned zero points.

Prognostic significance of serum vascular endothelial growth factor and Angiopoietin-2 in patients with lung cancer.

Introduction: Vascular endothelial growth factor (VEGF) and Angiopoietin-2 (Ang-2) are major angiogenic mediators in neovascularization process. In current literature both biomarkers are discussed separately and only for non-small cell lung cancer (NSCLC). So in this study we aimed to examine them together for both cell types NSCLC and small cell lung cancer (SCLC).

Patient and physician delay in the diagnosis and treatment of non-small cell lung cancer in Turkey.

Aim: The early diagnosis and treatment of lung cancer are important for the prognosis of patients with lung cancer. This study was undertaken to investigate patient and doctor delays in the diagnosis and treatment of NSCLC and the factors affecting these delays.

Materials And Methods: A total of 1016 patients, including 926 (91.

The evaluation of arsenic and cadmium levels in biological samples of cases with lung cancer.

Introduction: Chronic exposure to the toxic metals plays an important role among the causes of lung cancer beside of smoking. We aimed to evaluate the association between the histopathologic type of lung cancer and arsenic and cadmium levels in biological samples.

Materials And Methods: This study in a single center was conducted through the years 2009-2013, including 72 patients with lung cancer, within a prospective study design.

Association of cadmium but not arsenic levels in lung cancer tumor tissue with smoking, histopathological type and stage.

Background: To evaluate association of lung cancer with arsenic and cadmium levels measured in tumor tissue.

Materials And Methods: Ninety-five patients with lung cancer tumor tissue obtained surgically were included in this study. Arsenic and cadmium levels were measured and levels of metals were compared among types of lung cancer and with reference to patient data.

[Lung cancer and family history of cancer].

There are many studies supporting the family history in lung cancer. The study included 213 subjects with new and former diagnoses of lung cancer. Patients were enrolled from the Department of Chest Diseases Ankara University Faculty of Medicine and Atatürk Chest Diseases and Chest Surgery Training and Research Hospital between January-June 2005.

The prognostic value of serum epidermal growth factor receptor level in patients with non-small cell lung cancer.

Epidermal growth factor receptor (EGFR) has been implicated as a factor indicating tumour progression or as a prognostic factor in non-small cell lung cancer (NSCLC), in which its overexpression is often detected. The usefulness of identifying EGFR in serum from patients with NSCLC is controversial. This study was designed to identify serum EGFR levels in patients with NSCLC and to evaluate the relationship between serum EGFR levels and clinical stage, histological subtype and survival time.

[Lung cancer in women: clinical features and factors related to survival].

Lung cancer in women is increasing in worldwide. This process beginning with the difference on the susceptibility of lung cancer in women smokers may be different from men in the prognosis. In this study, it was aimed to evaluate the clinical features, and prognostic factors of female patients with lung cancer diagnosed between January 2000-December 2005.

Distribution of Bcl-2 gene expression and its prognostic value in non-small cell lung cancer.

The aim of this study was to determine the expression of Bcl-2 gene and prognostic importance of Bcl-2 expression in paraffin embedded blocks of patients diagnosed with non-small cell lung cancer (NSCLC). This study included the retrospective analysis of overall 46 patients diagnosed with NSCLC in our clinic between 1996 and 1999. In 16 (34.

The prognostic significance of vascular endothelial growth factor levels in sera of non-small cell lung cancer patients.

Background: Angiogenesis, the formation of new blood vessels from the existing vascular bed, is essential step for the growth and invasion of the primary tumor. Vascular endothelial growth factor (VEGF) is known to play crucial role in tumor angiogenesis. Increased serum VEGF levels may be associated with poor prognosis in patients with non-small cell lung cancer (NSCLC).

[A patient with meningeal carcinomatosis and small cell lung cancer].

Cranial metastasis because of lung cancer shows the poor prognosis. Cranial metastasis is common: In order lung, breast, skin, kidney, gastrointestinal system cancer is the 80% of the cause of metastasis. Cranial metastases are common in lung cancer especially in small cell lung cancer.

Elevated levels of circulating matrix metalloproteinase-9 in non-small cell lung cancer patients.

Elevated levels of matrix metalloproteinase have been implicated as playing important role in tumour progression in several types of cancers. Our aim was to determine whether these enzyme might be a useful tumour marker for lung cancer and also to evaluate the correlation of circulating levels of matrix metalloproteinase-9 (MMP-9) with tumour histology, staging, nodal status, metastasis and prognosis. Blood samples were collected from 35 nonsmall cell lung cancer patients who were diagnosed histologically, and 14 healthy controls.

Immunoglobulins and complement components in patients with lung cancer.

Based on data providing a correlation between immunoglobulin or complement components levels and malignancies and specific disease parameters, we examined the possible correlation between the immunoglobulins, complement component levels and the stage of disease and the survival of patients. Sera from 55 patients with lung cancer and 22 healthy donor were assayed in order to evaluate the concentration of IgG, IgA, IgM, IgE, C3, C4. No considerable differences were found between the levels of immunoglobulins in patients with carcinoma of the lung versus subjects in the control group.

High dose rate endobronchial brachytherapy effectively palliates symptoms due to inoperable lung cancer.

Background: Intraluminal brachytherapy has become an established treatment for major airway occlusion by relapsed or persistent inoperable endobronchial tumors. The aim of this study was to compare the palliation improvement pre- and post-radiotherapy.

Methods: The study group was 95 patients with the diagnosis of inoperable lung cancer who were eligible for HDR brachytherapy.

Bronchoalveolar lavage fluid analysis in individuals with chronic hepatitis C.

A number of disorders for which an association with hepatitis C virus infection exist. These disorders include essential mixed cryoglobulinemia, membranoproliferative glomerulonephritis, and idiopathic pulmonary fibrosis. This study was initiated to investigate the cellular content and lymphocyte subpopulations of bronchoalveolar lavage fluid obtained from individuals with chronic hepatitis C and to compare the results to those of controls.