Publications by authors named "İsmail Musab Gulacar"
Bi-allelic variants in Iron-Sulfur Cluster Scaffold (NFU1) have previously been associated with multiple mitochondrial dysfunctions syndrome 1 (MMDS1) characterized by early-onset rapidly fatal leukoencephalopathy. We report 19 affected individuals from 10 independent families with ultra-rare bi-allelic NFU1 missense variants associated with a spectrum of early-onset pure to complex hereditary spastic paraplegia (HSP) phenotype with a longer survival (16/19) on one end and neurodevelopmental delay with severe hypotonia (3/19) on the other. Reversible or irreversible neurological decompensation after a febrile illness was common in the cohort, and there were invariable white matter abnormalities on neuroimaging.
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- - IL-17A and IL-17F cytokines are linked to psoriasis, and the study aimed to analyze the impact of specific gene variants (IL-17A rs2275913 and IL-17F rs763780) on the development of the disease and the effectiveness of biological treatments.
- - The research involved 83 psoriasis patients and 69 healthy controls, but the results showed no significant differences in the gene variant frequencies between the groups; however, the IL-17A AA genotype was associated with a shorter disease duration and more effective treatment responses.
- - The study concluded that while the IL-17A rs2275913 variant may influence disease duration and treatment response, neither variant (IL-17A nor IL-
Aim: To investigate the effects of midazolam (MDZ) and thiopental on neonatal and adult rat brains.
Material And Methods: The study included adult and 7-day-old rats that were administered 9 mg/kg of MDZ, 60 mg/kg of thiopental, or both. The Bax, procaspase-3, and caspase-3 levels were assessed using Western Blot analysis and the total oxidative stress index (OSI) values were measured spectrophotometrically.
Background: Gastric and esophageal cancers are 2 of the most prevalent cancer types worldwide. Polymorphisms in the genes that code the methylenetetrahydrofolate reductase (MTHFR) enzyme increase the formation of both cancer types. In this study, it was aimed to research the relationship between the existence of and polymorphisms in patients with gastric and esophageal cancer and the lifespans of patients.
View Article and Find Full Text PDFAim: To investigate the relationship between paracetamol and expression levels of cyclooxygenase-2, cyclin B, cell viability and apoptosis in glioblastoma cell line.
Material And Methods: The A172 glioblastoma cells were treated with different concentrations of paracetamol and phosphate buffer saline as a vehicle for 24, 48, and 72 hours. Cell viability was detected by MTT.
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- A study involving 100 gastric cancer patients and 100 controls explored the connection between two specific genetic variants, IRS1 Gly972Arg and IRS2 Gly1057Asp, and the likelihood of developing gastric cancer.
- Results indicated that individuals with certain genotypes (IRS1 Gly/Arg and Arg/Arg) had significantly higher odds of being diagnosed with gastric cancer, suggesting a potential genetic risk factor, although findings for the IRS2 variant were not statistically significant.
Background/aim: Chemotherapeutic treatment options are often ineffective due to the development of resistance in cancer cells. Therefore, developing new anti-cancer agents is crucial for cancer treatment. Some triazine derivatives, their complexes and Copper(II) have anti-cancer effects on cancer cells.
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