Publications by authors named "İrem Sezer"
Article Synopsis
- A study investigates how reperfusion following a heart attack affects the blood vessels in areas not directly damaged by the attack in patients undergoing primary percutaneous intervention (pPCI).
- Researchers monitored changes in blood flow and pressure in these non-injured vessels before and one hour after the procedure, finding significant decreases in blood flow velocity and increases in microvascular resistance after reperfusion.
- The findings suggest that injury to the microcirculation can spread to healthy heart regions, particularly when there is a larger area of infarction and greater microvascular damage in the affected vessel.
Background Intramyocardial edema and hemorrhage are key pathological mechanisms in the development of reperfusion-related microvascular damage in ST-segment-elevation myocardial infarction. These processes may be facilitated by abrupt restoration of intracoronary pressure and flow triggered by primary percutaneous coronary intervention. We investigated whether pressure-controlled reperfusion via gradual reopening of the infarct-related artery may limit microvascular injury in patients undergoing primary percutaneous coronary intervention.
View Article and Find Full Text PDFFractional flow reserve (FFR) may not be immune from hemodynamic perturbations caused by both vessel and lesion related factors. The aim of this study was to investigate the impact of plaque- and vessel wall-related features of vulnerability on the hemodynamic effect of intermediate coronary stenoses. Methods and Results: In this cross-sectional study, patients referred to catheterization laboratory for clinically indicated coronary angiography were prospectively screened for angiographically intermediate stenosis (50-80%).
View Article and Find Full Text PDF