Screening Study on Serine Protease Inhibitory Activity of 10 Plant Species.

In this research, in vitro serine protease inhibitory activity of 10 plant species was evaluated, and extracts that showed strong activity were analyzed through high-performance liquid chromatography (HPLC). Rhododendron caucasicum Pall. (leaf) and Potentilla reptans L.

Chymotrypsin and Trypsin Inhibitory Activity of Some Medicinal Plants Collected from Rize (Türkiye).

In this research, the evaluation of in vitro chymotrypsin and trypsin inhibitory activities of ten plant species collected from Rize were aimed, and fractions that showed strong activity were analyzed through HPLC. Daphne pontica L. and Mentha longifolia (L.

Essential Oil Composition of Fruits of Eight Ferulago Species Growing in Türkiye and Multivariate Statistical Analyses.

In this study, the composition of the volatile oils obtained from the fruits of 8 Ferulago species (Ferulago cassia Boiss., F. isaurica Peşmen, F.

Essential Oils of Ferulago glareosa Kandemir&Hedge Roots and Aerial Parts: PCA and HCA Analyses.

Ferulago glareosa Kandemir & Hedge. is an endemic species of the family Apiaceae for Turkey and has interesting morphological characteristics compared to the other members of the genus Ferulago Koch. In this study we investigated the essential oil compositions of the roots and aerial parts of F.

The five species inhibited cell proliferation and induced apoptosis of A549, MCF-7, PC3 and SW480 cancer cells in vitro.

In this study, it was aimed to evaluate the cytotoxic and apoptotic activities of ethanolic extracts prepared from the roots of 5 species [ Boiss., Boiss. & Balansa, Peşmen & Quézel, (Boiss.

Ethnopharmacobotanical Findings of Medicinal Plants in the Kızılcahamam District of Ankara, Turkey.

Objectives: Folk medicines in Kızılcıhamam has not been investigated in detail so far. Thus, this study aimed to conduct a comprehensive investigation of folk medicine in the Kızılcahamam district.

Materials And Methods: Nine scientific field trips were organized to Kızılcahamam between April 2007 and July 2008.

Antibacterial, antifungal and enzyme inhibitory effects of selected plants from Turkey.

In this study, antibacterial, antifungal, antihyaluronidase, anticollagenase and antielastase activity of Hypericum bithynicum, Malva neglecta, Morus alba, Rubus discolor, Sambucus ebulus and Smilax excelsa were investigated. Methanol extracts of M. neglecta and R.

Activity-guided isolation of α-amylase, α-glucosidase, and pancreatic lipase inhibitory compounds from Rhus coriaria L.

The leaves and fruits of Rhus coriaria are traditionally used in Turkey for the treatment of diabetes. The aim of the present study is to determine α-amylase, α-glucosidase, and pancreatic lipase inhibitory activities of R. coriaria leaf and fruit ethanol extracts (80%), and to isolate active compounds against these enzymes.

Investigations on the anti-ulcerogenic activity of Sideritis caesarea H. Duman, Aytaç & Başer.

Ethnopharmacological Relevance: Aerial parts of Sideritis caesarea H. Duman, Aytaç & Başer are used for complaints such as stomach-aches, and intestinal spasms as traditional medicine in Kayseri, Turkey.

Aim Of Study: To investigate the anti-ulcerogenic activity by using bioassay guided fractionation technique (BAGF) and to identify the compound(s) that are responsible for anti-ulcerogenic activity through ethanol-induced anti-ulcerogenic activity model in vivo.

Antibacterial, antifungal and enzyme inhibitory effects of selected plants from Turkey.

In this study, antibacterial, antifungal, antihyaluronidase, anticollagenase and antielastase activity of Hypericum bithynicum, Malva neglecta, Morus alba, Rubus discolor, Sambucus ebulus and Smilax excelsa were investigated. Methanol extracts of M. neglecta and R.

Anti-ulcerogenic activity and isolation of the active principles from Sambucus ebulus L. leaves.

Ethnopharmacological Relevance: Sambucus ebulus L. has a very prominent place in Turkish folk medicine. Leaves of the plant are practiced externally to relieve rheumatic pain, to treat abscess, for wound healing and internally against hemorrhoids and stomachache.

Characterization of volatiles and anti-ulcerogenic effect of Turkish sweetgum balsam (Styrax liquidus).

Ethnopharmacological Relevance: Sweetgum, Styrax liquidus (Turkish sweetgum) is a resinous exudate obtained from the wounded barks of Liquidambar orientalis Miller tree which belongs to Altingiaceae (Hamamelidaceae). The plant material has been used for the treatment of peptic ulcer symptoms in Turkish folk medicine since centuries. In order to evaluate the claimed activity, we studied the anti-ulcerogenic effect of Styrax liquidus by using an in vivo anti-ulcerogenic activity model and to determine the chemical composition of the balsam.

Seroprevalence of varicella-zoster virus in the prevaccine era: a population-based study in Izmir, Turkey.

Purpose: To determine the population-based seroprevalence of varicella zoster virus (VZV) and related risk factors in Izmir.

Materials And Methods: A population-based household survey was conducted. A representative sample of the population older than 15 years of age was selected using multistage random sampling.

The prevalence and risk factors of human papillomavirus in female sex workers.

Objective: Human papillomavirus virus (HPV) is the major causative factor for cervical cancer, and sex workers are at high risk for HPV infection. In this study, we aimed to estimate the prevalence and risk factors of HPV infection among female sex workers (FSWs).

Materials And Methods: The study included 239 brothel-based FSWs who work in Izmir, Turkey.

Essential oil composition of five collections of Achillea biebersteinii from central Turkey and their antifungal and insecticidal activity.

The composition of the essential oils hydrodistilled from the aerial parts of five Achillea biebersteinii Afan samples, collected in central Turkey from Konya, Isparta and Ankara, were analyzed both by gas chromatography (GC-FID) and gas chromatography-mass spectrometry (GC-MS). Eighty-four components were identified, representing 87 to 99% of the total oil composition. The identified major components were 1,8-cineole (9-37%), camphor (16-30%) and p-cymene (1-27%).

In vivo activity assessment of a "honey-bee pollen mix" formulation.

Honey-bee pollen mix (HBM) formulation is claimed to be effective for the treatment of asthma, bronchitis, cancers, peptic ulcers, colitis, various types of infections including hepatitis B, and rheumatism by the herb dealers in northeast Turkey. In the present study, in vivo antinociceptive, anti-inflammatory, gastroprotective and antioxidant effects of pure honey and HBM formulation were evaluated comparatively. HBM did not show any significant gastroprotective activity in a single administration at 250 mg/kg dose, whereas a weak activity was observed after three days of successive administration at 500 mg/kg dose.

Evaluation of the antiulcerogenic activity profile of a flavonol diglucoside from Equisetum palustre L.

Ethnopharmacological Relevance: The aerial parts of Equisetum palustre L. are used to treat peptic ulcer disease in Turkey. In a previous study, a flavonol diglucoside i.

An anti-ulcerogenic flavonol diglucoside from Equisetum palustre L.

Ethnopharmacological Relevance: The aerial parts of Eqiusetum palustre L. is used to treat peptic ulcer in Karaman, Turkey.

Aim Of The Study: The present study was undertaken to evaluate the in vivo gastroprotective potential and structure elucidation of the active constituent(s) through bioassay-guided fractionation procedures by using ethanol (EtOH)-induced ulcerogenesis model in rats.

The efficiency of Viscum album ssp. album and Hypericum perforatum on human immune cells in vitro.

Viscum album L. ssp. album and Hypericum perforatum L.

Antiviral and antimicrobial activities of three sesquiterpene lactones from Centaurea solstitialis L. ssp. solstitialis.

Three sesquiterpene lactones (centaurepensin = chlorohyssopifolin A, chlorojanerin and 13-acetyl solstitialin A) isolated from the aerial parts of Centaurea solstitialis L. ssp. solstitialis (Asteraceae) were investigated for antimicrobial and antiviral activities.

Evaluation of the anti-ulcerogenic effect of sesquiterpene lactones from Centaurea solstitialis L. ssp. solstitialis by using various in vivo and biochemical techniques.

The guaianolide type sesquiterpene lactones chlorojanerin, 13-acetyl solstitialin A and solstitialin A were identified as the anti-ulcerogenic components of the chloroform extract of the aerial parts of Centaurea solstitialis ssp. solstitialis (Asteraceae). In this study, these compounds were investigated by using various in vivo ulcer models in rats and mice.

Anti-ulcerogenic activity of some plants used in folk medicine of Pinarbasi (Kayseri, Turkey).

Several ethnomedicinal plant remedies used in Pinarbasi, Kayseri, in particular those which are used for the treatment of several peptic ulcer symptoms such as stomach ache, heartburn, etc. were selected for evaluation of their anti-ulcerogenic potential. In order to confirm the claimed activities, decoctions were prepared from aerial parts of Malva neglecta Wallr.

Evaluation of in vivo biological activity profile of isoorientin.

Anti-nociceptive, anti-inflammatory and gastroprotective activities of the known C-glycosyl flavonoid, isoorientin, were studied in rats and mice. For the anti-nociceptive activity assessment the p-benzoquinone-induced writing test, for the anti-inflammatory activity the carrageenan-induced hind paw edema model in mice, and for the gastroprotective activity the EtOH-induced ulcerogenesis model in rats were used. Isoorientin was shown to possess significant anti-nociceptive and anti-inflammatory activities at 15 mg/kg and 30 mg/kg doses, without inducing any apparent acute toxicity as well as gastric damage.

Isolation of anti-ulcerogenic sesquiterpene lactones from Centaurea solstitialis L. ssp. solstitialis through bioassay-guided fractionation procedures in rats.

The fresh spiny flowers of Centaurea solstitialis ssp. solstitialis (CSS) are used for the treatment of peptic ulcers in Turkey. Ethanol (80%) extract of CSS exhibited significant anti-ulcerogenic effect on the ethanol-induced ulcerogenesis model in rats.

Anti-ulcerogenic lignans from Taxus baccata L.

Four lignan type compounds, lariciresinol, taxiresinol, isolariciresinol and 3-demethyl-iso-lariciresinol, were isolated from the heartwood of Taxus baccata L. (Taxaceae) growing in Turkey through chromatographic techniques. In vivo anti-ulcerogenic potency of these compounds was investigated on ethanol-induced ulcerogenesis model in rats at two different doses, 50 and 100 mg/kg.