Endocan Measurement for Active Behçet Disease.

Objectives: This study aims to investigate the relationships between serum endocan, vascular endothelial growth factor (VEGF), and tumor necrosis factor-alpha (TNF-α) levels in active Behçet disease.

Patients And Methods: Forty patients with active Behçet disease (24 males, 16 females; mean age 37.6±8.

Decreased paraoxonase1 activity and increased malondialdehyde and oxidative DNA damage levels in primary open angle glaucoma.

To investigate the malondialdehyde (MDA) levels, paraoxonase1 (PON1) activity and 8-hydroxy 2-deoxyguanosine (8-OHdG) levels in the primary open angle glaucoma (POAG) patient. Blood samples from 52 healthy individuals and 53 patients with POAG were analyzed for MDA and 8-OHdG by HPLC (high-performance liquid chromatography) and PON1 by spectrophotometry. The data obtained were analyzed statistically.

Retinal Nerve Fiber Layer Thickness in Early-Stage Diabetic Retinopathy With Vitamin D Deficiency.

Purpose: To evaluate retinal nerve fiber layer (RNFL) thickness in early-stage diabetic retinopathy (DR) patients with and without vitamin D deficiency (VDD).

Methods: This study compared 50 early-stage DR patients with VDD (group 1) and 50 early-stage DR patients without VDD (group 2). All patients were examined by the same ophthalmologist.

Paintball-related ocular trauma: Paintball or Painball?

Background: The aim of this study is to describe the type and severity of paintball-related ocular trauma and to determine the necessary precautions to minimize the risk of ocular injury regardless of whether adequate eye protection was used.

Material And Methods: A retrospective chart review identified patients treated for paintball-related ocular trauma at the Ataturk University Medical Hospital from June 2010 through March 2013. A descriptive analysis of data was performed.

Oxidative DNA damage in patients with cataract.

Purpose: This study examines the levels of oxidative damage in patients with cataract.

Methods: Blood samples were collected from 60 patients with cataract and 60 age- and gender-matched healthy individuals to measure 8-hydroxy 2-deoxyguanosine (8-OHdG) and malondialdehyde (MDA) levels.

Results: A significant difference was observed in leukocyte 8-OHdG levels in patients with cataract in comparison with healthy persons (p < 0.

The effects of zinc sulfate on the levels of some elements and oxidative stress occurring in lenses of rats exposed to total cranium radiotherapy.

Objective: There is currently substantial clinical interest in zinc (Zn) as an antioxidant and a protective agent against radiation-related normal tissue injury. To further assess the potential antioxidative effects, the effects of Zn were studied in rat lenses, a model of radiation-induced oxidative stress.

Materials And Methods: Sprague-Dawley rats were divided into three equal groups.

Agmatine as retinal protection from ischemia-reperfusion injury in guinea pigs.

Purpose: To determine the neuroprotective effect of agmatine (Agm) on the retinas of guinea pigs subjected to a transient ischemia-reperfusion insult.

Methods: Twenty-eight guinea pigs were randomly divided into four groups. Forty-five minutes before ischemic insult, the guinea pigs were intraperitoneally administered either Agm (50 mg/kg) (Agm 1) or saline (control 1 group) once, or twice separated by a 12-h interval (Agm 2; control 2).

Decreased serum paraoxonase 1 activity and increased serum homocysteine and malondialdehyde levels in age-related macular degeneration.

Age-related macular degeneration (AMD) is one of the most common causes of vision loss. AMD has been classified into two forms: atrophic and exudative forms. The exudative form is associated with choroidal neovascularization of the subretinal macular region, resulting in a sudden loss of central vision.

Effect of photodynamic therapy with posterior sub-tenon triamcinolone acetonide on predominantly classic choroidal neovascularization: one-year results.

Objective: The aim of this study was to compare the results of monotherapy (photodynamic therapy) and combined therapy (photo-dynamic therapy with posterior sub-Tenon triamcinolone acetonide) in age-related macular degeneration (AMD).

Materials And Methods: Forty eyes from forty patients with diagnosed neovascular AMD were enrolled in this study during March-2005 - October-2008. All patients were grouped in either the study or the control group.

Increased serum levels of leptin in retinal vein occlusion.

Retinal vein occlusion is an important cause of visual loss. Several ocular and systemic conditions have been reported for retinal vein occlusion. The pathogenesis of thrombus formation in the retinal vein, which results in retinal vein occlusion, is unclear.

Vitamin E and L-carnitine, separately or in combination, in the prevention of radiation-induced brain and retinal damages.

Our aim was to determine the effects of vitamin E and L-carnitine supplementation, individually or in combination, on radiation-induced brain and retinal damages in a rat model. Group 1 received no treatment (control arm). Group 2 received a total dose of 15 Gy external radiotherapy (RT) to whole brain by Cobalt-60 teletherapy machine.

Effect of acute submaximal exercise on intraocular pressure in athletes and sedentary subjects.

The existing literature is controversial regarding the relationship between physical fitness and intraocular pressure (IOP). Therefore, the effects of acute submaximal exercise on IOP were compared in athletes and sedentary subjects. Acute exercise increased IOP in male athletes, but had no effect in sedentary men.

Long-term effects of mild exercise on intraocular pressure in athletes and sedentary subjects.

The long-term effects of acute submaximal exercise on intraocular pressures (IOPs) of right-and left-eyes and recovery times to basement levels of IOP in postexercise periods in sedentary and physically fit subjects were investigated. Twenty-five sedentary and 24 physically fit subjects, ranging in age 17 to 22 years, participated. Intraocular pressures were measured by a pneumotonometer.

The effect of L-carnitine in the prevention of ionizing radiation-induced cataracts: a rat model.

Background: The objective was to determine the antioxidant role of L-carnitine (LC) against ionizing radiation-induced cataracts in lens after total cranium irradiation of rats with a single dose of 5 Gy.

Methods: Sprague-Dawley rats were used in this experiment and were divided into three groups. Group 1 did not receive LC or irradiation (control group).

Radioprotective effects of melatonin on radiation-induced cataract.

One of the mechanisms proposed to explain lens opacification is the oxidation of crystallins, either by radiation or reactive oxygen species (ROS). It has been shown that melatonin has both an anti-peroxidative effect on several tissues and a scavenger effect on ROS. The purpose of this study was to determine the antioxidant role of melatonin (5 mg/kg/day) against radiation-induced cataract in the lens after total-cranium irradiation of rats with a single dose of 5 Gy.

Pseudotumor cerebri secondary to subacute sclerosing panencephalitis.

Pseudotumor cerebri is characterized by signs of raised intracranial pressure occurring in the absence of obvious brain pathology. We present an 8-year-old boy with pseudotumor cerebri secondary to subacute sclerosing panencephalitis. The reported patient suggests a possible association between subacute sclerosing panencephalitis and pseudotumor cerebri and that subacute sclerosing panencephalitis should be added to the list of disorders known to be associated with pseudotumor cerebri.

Effects of oral Ginkgo biloba supplementation on cataract formation and oxidative stress occurring in lenses of rats exposed to total cranium radiotherapy.

Purpose: To determine the antioxidant role of Ginkgo biloba (GB) in preventing radiation-induced cataracts in the lens after total-cranium irradiation of rats with a single radiation dose of 5 Gy.

Methods: Sprague-Dawley rats were randomly divided into three groups. Group 1 received neither GB nor irradiation (control group).

Alterations of fatty acid composition of erythrocyte membrane in type 2 diabetes patients with diabetic retinopathy.

Purpose: To investigate the relationship between the erythrocyte membrane fatty acid components and diabetic retinopathy in patients with type 2 diabetes mellitus.

Methods: The study was performed in 40 patients. Thirty of the 40 were type 2 diabetic patients classified into three groups according to Early Treatment Diabetic Retinopathy Study Group (ETDRS) criteria: 10 with mild-moderate nonproliferative retinopathy (group 1), 10 with moderate-severe nonproliferative retinopathy (group 2), and 10 with proliferative retinopathy (group 3).

Serum oxidant/antioxidant status in patients with Behçet's disease.

The aims of this study were to assess whether the increased oxidative stress in affected tissues is reflected by serum lipid peroxidation and to check for alterations in serum levels of extracellular antioxidants and antioxidant enzyme activities in patients with Behcet's disease (BD). Serum malondialdehyde (MDA) and ceruloplasmin (Cp) levels and CuZn-superoxide dismutase (CuZn-SOD) and glutathione peroxidase (GSH-Px) activities were increased, while serum transferrin (Trf) levels were diminished in patients with active ocular BD (n = 19), inactive ocular BD (n=18), and nonocular BD (n=15), compared to healthy controls (n = 20). Serum MDA levels in patients with active ocular BD and nonocular BD were significantly higher than in the inactive ocular BD group.

Unilateral nostril breathing in intraocular pressure of right-handed healthy subjects.

The effects of unilateral forced nostril breathing on the intraocular pressures of right and left eyes was studied in 24 male and 26 female right-handed adults. In men, the forced breathing through both the right and left nostrils significantly decreased the intraocular pressures of both right and left eyes. For women, the forced breathing through right nostril did not affect the intraocular pressures of right and left eyes, and the forced breathing through left nostril also had no effect on the intraocular pressure of right eye, although it decreased the intraocular pressure of left eye significantly.