Publications by authors named "' Esiteli A P Tu'i"
We report a case of small bowel perforation from ileo-ileal intussusception with necrotising enterocolitis (NEC) after indomethacin exposure mimicking spontaneous intestinal perforation in an extremely preterm neonate. Indomethacin exposure can cause mesenteric hypoperfusion, resulting in an ischaemic lead point for intussusception and NEC. We advocate that intussusception should be considered as one of the differentials for neonates with recurrent feeding intolerance postindomethacin exposure.
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- - Cell division in *Escherichia coli* is controlled by MinD and MinE proteins, creating oscillatory concentration waves that help determine where the cell divides.
- - The study examines how these MinD gradients are affected by molecular interactions and diffusion, observing changes during cell elongation, like steepening gradients and stabilized oscillation periods.
- - A one-dimensional model simulates the molecular interactions, showing the complex dynamics at play and highlighting the importance of concentration gradients in cellular functions.
While cryogenic electron microscopy (cryo-EM) is fruitfully used for harvesting high-resolution structures of sizable macromolecules, its application to small or flexible proteins composed of small domains like immunoglobulin (IgG) remain challenging. Here, we applied single particle cryo-EM to Rituximab, a therapeutic IgG mediating anti-tumor toxicity, to explore its solution conformations. We found Rituximab molecules exhibited aggregates in cryo-EM specimens contrary to its solution behavior, and utilized a non-ionic detergent to successfully disperse them as isolated particles amenable to single particle analysis.
View Article and Find Full Text PDFThe study of long-range transport effects on marine fine particles (PM), particularly in remote sites such as the Dongsha Islands, is pivotal for advancing our understanding of air pollution dynamics on a regional scale and for formulating effective environmental policies. PM concentrations were examined over three consecutive years and grouped based on their transport routes. The backward trajectory simulation revealed that high PM concentrations were observed in the West Channel, originating from North and Central China, the Korean Peninsula, and the Japanese Islands, opposed to the East Channel.
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- Diabetes mellitus and chronic kidney disease are increasing global health issues that often come with similar neuromuscular problems affecting daily life; distinguishing between them could be crucial for early detection and continuous monitoring.
- A study utilized a new pinch-holding-up activity test, combined with advanced deep learning models, to analyze motor performance of 271 participants across three groups: healthy adults, those with diabetes, and those with chronic kidney disease.
- The deep learning models achieved high accuracy rates of over 95% in distinguishing between the groups, indicating significant differences in sensorimotor performance that might lead to better clinical screening methods for these conditions.